Preventive Oral Treatment with Resveratrol Pro-prodrugs Drastically Reduce Colon Inflammation in Rodents

There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring polyphenol resveratrol exerts anti-inflammatory properties. However, its rapid metabolism diminishes its effectiveness in the colon. The design of prodrugs to targeting active molec...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-10, Vol.53 (20), p.7365-7376
Hauptverfasser:	Larrosa, Mar, Tomé-Carneiro, Joao, Yáñez-Gascón, María J, Alcántara, David, Selma, María V, Beltrán, David, García-Conesa, María T, Urbán, Cristina, Lucas, Ricardo, Tomás-Barberán, Francisco, Morales, Juan C, Espín, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cell Line Colitis - chemically induced Colitis - pathology Colitis - prevention & control Colon - drug effects Colon - metabolism Colon - pathology Cytokines - metabolism Dextran Sulfate Diarrhea - metabolism Diarrhea - pathology Diarrhea - prevention & control Dinoprostone - biosynthesis Feces - microbiology Gastrointestinal Transit - drug effects Glucosides - chemical synthesis Glucosides - metabolism Glucosides - therapeutic use Humans Intestinal Absorption - drug effects Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Mice Mice, Inbred C57BL Peroxidase - metabolism Prodrugs - chemical synthesis Prodrugs - metabolism Prodrugs - therapeutic use Stereoisomerism Stilbenes - chemical synthesis Stilbenes - metabolism Stilbenes - therapeutic use Structure-Activity Relationship
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