Anesthetic Technique and the Cytokine and Matrix Metalloproteinase Response to Primary Breast Cancer Surgery

Breast cancer is the most common malignancy in women. Surgery remains the most effective treatment. Several perioperative factors, including the surgical stress response, many anesthetics and opioids, adversely affect immune function. Regional anesthesia-analgesia attenuates perioperative immunosupp...

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Veröffentlicht in:	Regional anesthesia and pain medicine 2010-11, Vol.35 (6), p.490-495
Hauptverfasser:	Deegan, Catherine A., Murray, David, Doran, Peter, Moriarty, Denis C., Sessler, Daniel I., Mascha, Ed, Kavanagh, Brian P., Buggy, Donal J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analgesics, Opioid - administration & dosage Anesthesia Anesthesia, Conduction Anesthetics, Inhalation - administration & dosage Anesthetics, Intravenous - administration & dosage Anesthetics, Local - administration & dosage Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - immunology Breast Neoplasms - pathology Breast Neoplasms - surgery Bupivacaine - administration & dosage Bupivacaine - analogs & derivatives Cancer surgery Cytokines Cytokines - blood Female Humans Immunity, Cellular - drug effects Interferon-gamma - blood Interleukins - blood Ireland Levobupivacaine Mastectomy Matrix Metalloproteinase 1 - blood Matrix Metalloproteinase 3 - blood Matrix Metalloproteinase 9 - blood Matrix Metalloproteinases - blood Methyl Ethers - administration & dosage Middle Aged Morphine - administration & dosage Narcotics Nerve Block Pain, Postoperative - etiology Pain, Postoperative - prevention & control Pilot Projects Propofol - administration & dosage Regional anesthesia Sevoflurane Time Factors Treatment Outcome Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF
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