Treatment effectiveness and adherence in patients with schizophrenia treated with risperidone long-acting injection
Abstract This study investigated the variables related to the effectiveness and adherence to treatment with risperidone long-acting injection (RLAI) in patients with schizophrenia. We performed a retrospective medical chart review of 137 patients with schizophrenia who were prescribed RLAI between J...
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| Veröffentlicht in: | Psychiatry research 2010-11, Vol.180 (1), p.16-19 |
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| creator | Chang, Chen-Lin Tzeng, Dong-Sheng Lung, For-Wey |
| description | Abstract This study investigated the variables related to the effectiveness and adherence to treatment with risperidone long-acting injection (RLAI) in patients with schizophrenia. We performed a retrospective medical chart review of 137 patients with schizophrenia who were prescribed RLAI between July 2004 and December 2006. Cox regression analysis showed that the effectiveness of treatment in patients treated with RLAI was affected significantly by the provision of home care and the use of illicit drugs. The adherence of patients to treatment with RLAI was affected most by the provision of home care. Bayesian analysis showed that patients who received the provision of home care or who had no history of illicit drug use continued treatment for, on average, 15.27 and 17.14 days longer, respectively, than those who did not receive such care or take illicit drugs. Patients who received the provision of home care adhered to treatment for 343.98 more days than those who did not. Even though patients taking RLAI show better adherence than those taking oral risperidone, home care services can have a significant additional effect on adherence. Randomized clinical follow-up trial studies are necessary to explore the risk factors for nonadherence in more detail. |
| doi_str_mv | 10.1016/j.psychres.2009.11.005 |
| format | Article |
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We performed a retrospective medical chart review of 137 patients with schizophrenia who were prescribed RLAI between July 2004 and December 2006. Cox regression analysis showed that the effectiveness of treatment in patients treated with RLAI was affected significantly by the provision of home care and the use of illicit drugs. The adherence of patients to treatment with RLAI was affected most by the provision of home care. Bayesian analysis showed that patients who received the provision of home care or who had no history of illicit drug use continued treatment for, on average, 15.27 and 17.14 days longer, respectively, than those who did not receive such care or take illicit drugs. Patients who received the provision of home care adhered to treatment for 343.98 more days than those who did not. Even though patients taking RLAI show better adherence than those taking oral risperidone, home care services can have a significant additional effect on adherence. Randomized clinical follow-up trial studies are necessary to explore the risk factors for nonadherence in more detail.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2009.11.005</identifier><identifier>PMID: 20488552</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adherence ; Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - administration & dosage ; Bayes Theorem ; Biological and medical sciences ; Effectiveness ; Female ; Home care provision ; Humans ; Male ; Medical sciences ; Medication Adherence - psychology ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Proportional Hazards Models ; Psychiatry ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Psychoses ; Retrospective Studies ; Risperidone ; Risperidone - administration & dosage ; Schizophrenia ; Schizophrenia - drug therapy ; Schizophrenic Psychology ; Taiwan</subject><ispartof>Psychiatry research, 2010-11, Vol.180 (1), p.16-19</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-e355a14fde6b3c89b01aad2149a1b53a56a8753a4eae3b0a552a1a692a1a37013</citedby><cites>FETCH-LOGICAL-c452t-e355a14fde6b3c89b01aad2149a1b53a56a8753a4eae3b0a552a1a692a1a37013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psychres.2009.11.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23387863$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20488552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Chen-Lin</creatorcontrib><creatorcontrib>Tzeng, Dong-Sheng</creatorcontrib><creatorcontrib>Lung, For-Wey</creatorcontrib><title>Treatment effectiveness and adherence in patients with schizophrenia treated with risperidone long-acting injection</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract This study investigated the variables related to the effectiveness and adherence to treatment with risperidone long-acting injection (RLAI) in patients with schizophrenia. We performed a retrospective medical chart review of 137 patients with schizophrenia who were prescribed RLAI between July 2004 and December 2006. Cox regression analysis showed that the effectiveness of treatment in patients treated with RLAI was affected significantly by the provision of home care and the use of illicit drugs. The adherence of patients to treatment with RLAI was affected most by the provision of home care. Bayesian analysis showed that patients who received the provision of home care or who had no history of illicit drug use continued treatment for, on average, 15.27 and 17.14 days longer, respectively, than those who did not receive such care or take illicit drugs. Patients who received the provision of home care adhered to treatment for 343.98 more days than those who did not. Even though patients taking RLAI show better adherence than those taking oral risperidone, home care services can have a significant additional effect on adherence. Randomized clinical follow-up trial studies are necessary to explore the risk factors for nonadherence in more detail.</description><subject>Adherence</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - administration & dosage</subject><subject>Bayes Theorem</subject><subject>Biological and medical sciences</subject><subject>Effectiveness</subject><subject>Female</subject><subject>Home care provision</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medication Adherence - psychology</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Proportional Hazards Models</subject><subject>Psychiatry</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Psychoses</subject><subject>Retrospective Studies</subject><subject>Risperidone</subject><subject>Risperidone - administration & dosage</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenic Psychology</subject><subject>Taiwan</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EokvhL1S5IE4JHjvOxwWBKr6kShwoZ2viTLpesk7wZIuWX4-j3YLEhYvn4GfeGT-yEFcgC5BQvd4VMx_dNhIXSsq2ACikNI_EBppa5TUo_VhsEmhyqBu4EM-Yd1JKBW37VFwoWTaNMWoj-DYSLnsKS0bDQG7x9xSIOcPQZ9hvKVJwlPmQzbj4hHH20y_bjN3W_5rmtEDwmC1rCPWnq-h5puj7KVA2TuEux5Qa7lLGbs2fwnPxZMCR6cW5XopvH97fXn_Kb758_Hz97iZ3pVFLTtoYhHLoqeq0a9pOAmKvoGwROqPRVNjUqZaEpDuJ6T0IWLXrqWsJ-lK8OuXOcfpxIF7s3rOjccRA04FtXUmlTd3UiaxOpIsTc6TBztHvMR4tSLv6tjv74Nuuvi2ATb5T49V5xKHbU_-n7UFwAl6eAWSH4xAxOM9_Oa2buql04t6eOEpC7j1Fy86v6nsfkzXbT_7_u7z5J8KNPvg09TsdiXfTIYak24JlZaX9uv6O9XPIVsoSWq1_A-BAuas</recordid><startdate>20101130</startdate><enddate>20101130</enddate><creator>Chang, Chen-Lin</creator><creator>Tzeng, Dong-Sheng</creator><creator>Lung, For-Wey</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101130</creationdate><title>Treatment effectiveness and adherence in patients with schizophrenia treated with risperidone long-acting injection</title><author>Chang, Chen-Lin ; Tzeng, Dong-Sheng ; Lung, For-Wey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-e355a14fde6b3c89b01aad2149a1b53a56a8753a4eae3b0a552a1a692a1a37013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adherence</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - administration & dosage</topic><topic>Bayes Theorem</topic><topic>Biological and medical sciences</topic><topic>Effectiveness</topic><topic>Female</topic><topic>Home care provision</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medication Adherence - psychology</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proportional Hazards Models</topic><topic>Psychiatry</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Psychoses</topic><topic>Retrospective Studies</topic><topic>Risperidone</topic><topic>Risperidone - administration & dosage</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenic Psychology</topic><topic>Taiwan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Chen-Lin</creatorcontrib><creatorcontrib>Tzeng, Dong-Sheng</creatorcontrib><creatorcontrib>Lung, For-Wey</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Chen-Lin</au><au>Tzeng, Dong-Sheng</au><au>Lung, For-Wey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment effectiveness and adherence in patients with schizophrenia treated with risperidone long-acting injection</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2010-11-30</date><risdate>2010</risdate><volume>180</volume><issue>1</issue><spage>16</spage><epage>19</epage><pages>16-19</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract This study investigated the variables related to the effectiveness and adherence to treatment with risperidone long-acting injection (RLAI) in patients with schizophrenia. We performed a retrospective medical chart review of 137 patients with schizophrenia who were prescribed RLAI between July 2004 and December 2006. Cox regression analysis showed that the effectiveness of treatment in patients treated with RLAI was affected significantly by the provision of home care and the use of illicit drugs. The adherence of patients to treatment with RLAI was affected most by the provision of home care. Bayesian analysis showed that patients who received the provision of home care or who had no history of illicit drug use continued treatment for, on average, 15.27 and 17.14 days longer, respectively, than those who did not receive such care or take illicit drugs. Patients who received the provision of home care adhered to treatment for 343.98 more days than those who did not. Even though patients taking RLAI show better adherence than those taking oral risperidone, home care services can have a significant additional effect on adherence. Randomized clinical follow-up trial studies are necessary to explore the risk factors for nonadherence in more detail.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>20488552</pmid><doi>10.1016/j.psychres.2009.11.005</doi><tpages>4</tpages></addata></record> |
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| subjects | Adherence Adult Adult and adolescent clinical studies Antipsychotic Agents - administration & dosage Bayes Theorem Biological and medical sciences Effectiveness Female Home care provision Humans Male Medical sciences Medication Adherence - psychology Middle Aged Neuropharmacology Pharmacology. Drug treatments Proportional Hazards Models Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Retrospective Studies Risperidone Risperidone - administration & dosage Schizophrenia Schizophrenia - drug therapy Schizophrenic Psychology Taiwan |
| title | Treatment effectiveness and adherence in patients with schizophrenia treated with risperidone long-acting injection |
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