EFFECT OF NICORANDIL ON POST-ISCHAEMIC CONTRACTILE DYSFUNCTION IN THE HEART: ROLES OF ITS ATP-SENSITIVE K' CHANNEL OPENING PROPERTY AND NITRATE PROPERTY

SUMMARY 1. This study aimed to characterize the effect of nicorandil (NC) on myocardial stunning and the role of ATP‐sensitive K+ (Katp) channel opening property in its cardioprotective action. 2. In open‐chest anaesthetized rabbits, myocardial stunning was induced by 10 min of coronary occlusion fo...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1993-09, Vol.20 (9), p.595-602
Hauptverfasser:	Iwamoto, Toshihiro, Miura, Tetsuji, Urabe, Kazuyuki, Itoya, Masao, Shimamoto, Kazuaki, Iimura, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Animals Antianginal agents. Coronary vasodilator agents ATP sensitive K channel Biological and medical sciences Cardiovascular system Glyburide - pharmacology Hemodynamics - drug effects Infusions, Intravenous Ion Channel Gating - drug effects Male Medical sciences Myocardial Contraction - drug effects Myocardial Ischemia - drug therapy Myocardial Ischemia - physiopathology Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - physiopathology myocardial stunning Myocardial Stunning - drug therapy Myocardial Stunning - physiopathology Niacinamide - analogs & derivatives Niacinamide - pharmacology Nicorandil Nitrates - physiology Nitroglycerin - pharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - physiology Premedication rabbit Rabbits Vasodilator Agents - pharmacology
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