DNA methylation or histone modification status in metastasis and angiogenesis-related genes: a new hypothesis on usage of DNMT inhibitors and S-adenosylmethionine for genome stability

Metastasis is a leading cause of mortality and morbidity in cancer. This process needs angiogenesis. The biology underlying cancer, metastasis, and angiogenesis has been investigated so as to determine the therapeutic targets. Invasive and metastatic cancer cells have undergone numerous genetic and...

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Veröffentlicht in:	Cancer and metastasis reviews 2010-12, Vol.29 (4), p.655-676
Hauptverfasser:	SAHIN, Mehmet, SAHIN, Emel, GÜMÜSLÜ, Saadet, ERDOGAN, Abdullah, GÜLTEKIN, Meral
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Basement membranes Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cytoskeleton Development and progression Differentiation DNA DNA Methylation DNA Modification Methylases - antagonists & inhibitors DNA Modification Methylases - genetics DNA Modification Methylases - metabolism Endothelial cells Endothelium Epigenetic inheritance epigenetics Gene Expression Regulation, Neoplastic Genes Genetic aspects Genetic research Genomes Genomic Instability Genomics Health aspects Histone deacetylase Histones - genetics Histones - metabolism Humans Invasiveness Medical sciences Metastases Metastasis Methylation Morbidity Mortality Neoplasm Metastasis Neoplasms - blood supply Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Neovascularization, Pathologic - genetics Non-Thematic Review Oncology Proteases Proteolytic enzymes S-Adenosylmethionine S-Adenosylmethionine - pharmacology S-Adenosylmethionine - therapeutic use Tumors
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