The phosphoinositide-3 kinase survival signaling mechanism in sepsis

Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2010-11, Vol.34 (5), p.442-449
Hauptverfasser:	Manukyan, Mariuxi C, Weil, Brent R, Wang, Yue, Abarbanell, Aaron M, Herrmann, Jeremy L, Poynter, Jeffrey A, Meldrum, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Cell Survival Enzyme Activation Gene Expression Regulation - physiology Humans Immunity, Innate Inflammation - enzymology Mice Mice, Knockout Models, Biological Multiple Organ Failure - enzymology Multiple Organ Failure - etiology Multiple Organ Failure - prevention & control NF-kappa B - physiology Peritonitis - enzymology Peritonitis - immunology Peritonitis - physiopathology Phosphatidylinositol 3-Kinases - immunology Phosphatidylinositol 3-Kinases - physiology Protein Isoforms - physiology Protein Kinases - physiology Proto-Oncogene Proteins c-akt - physiology Sepsis - complications Sepsis - enzymology Sepsis - immunology Sepsis - physiopathology Signal Transduction - physiology
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