Anaplastic Thyroid Carcinoma: Morphologic Findings and PAX-8 Expression in Cytology Specimens
To evaluate the morphologic findings most encountered in anaplastic thyroid carcinomas (ATCs) and evaluate for the expression of PAX-8. The cytology specimens from 21 cases of ATC were evaluated for the following several cytologic criteria: cell morphology, pleomorphism, presence or absence of multi...
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| Veröffentlicht in: | Acta cytologica 2010-09, Vol.54 (5), p.668-672 |
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| creator | RIVERA, Michael SHANG, Cristina GERHARD, Rene GHOSSEIN, Ronald LIN, Oscar |
| description | To evaluate the morphologic findings most encountered in anaplastic thyroid carcinomas (ATCs) and evaluate for the expression of PAX-8.
The cytology specimens from 21 cases of ATC were evaluated for the following several cytologic criteria: cell morphology, pleomorphism, presence or absence of multinucleated cells, colloid, neutrophilic infiltrate and well-differentiated component. Immunohistochemical studies for PAX-8 were performed on cell blocks in selected cases.
The most common morphology present was epithelioid, followed by spindle, multinucleated giant cell and rhabdoid, with 75% demonstrating more than 1 cell morphology. Marked pleomorphism (81%), neutrophilic infiltrate (90%) and necrosis (63%) were frequent. No nuclear grooves, colloid or well-differentiated component was identified in any case. Immunocytochemical stains for PAX-8 were negative in 5 cases in which a cell block was available.
ATC is a tumor with diverse morphologic characteristics, and more than 1 cell morphology is usually present. A neutrophilic infiltrate is a common finding and represents a clue to the correct diagnosis. |
| doi_str_mv | 10.1159/000325230 |
| format | Article |
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The cytology specimens from 21 cases of ATC were evaluated for the following several cytologic criteria: cell morphology, pleomorphism, presence or absence of multinucleated cells, colloid, neutrophilic infiltrate and well-differentiated component. Immunohistochemical studies for PAX-8 were performed on cell blocks in selected cases.
The most common morphology present was epithelioid, followed by spindle, multinucleated giant cell and rhabdoid, with 75% demonstrating more than 1 cell morphology. Marked pleomorphism (81%), neutrophilic infiltrate (90%) and necrosis (63%) were frequent. No nuclear grooves, colloid or well-differentiated component was identified in any case. Immunocytochemical stains for PAX-8 were negative in 5 cases in which a cell block was available.
ATC is a tumor with diverse morphologic characteristics, and more than 1 cell morphology is usually present. A neutrophilic infiltrate is a common finding and represents a clue to the correct diagnosis.</description><identifier>ISSN: 0001-5547</identifier><identifier>EISSN: 1938-2650</identifier><identifier>DOI: 10.1159/000325230</identifier><identifier>PMID: 20968153</identifier><identifier>CODEN: ACYTAN</identifier><language>eng</language><publisher>Basel: Karger</publisher><subject>Aged ; Biological and medical sciences ; Biopsy, Fine-Needle ; Carcinoma - metabolism ; Carcinoma - pathology ; Cytodiagnosis ; Diagnosis, Differential ; Endocrinopathies ; Female ; Giant Cells - metabolism ; Giant Cells - pathology ; Humans ; Immunoenzyme Techniques ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Malignant tumors ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Paired Box Transcription Factors - metabolism ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; PAX8 Transcription Factor ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Acta cytologica, 2010-09, Vol.54 (5), p.668-672</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23403895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20968153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIVERA, Michael</creatorcontrib><creatorcontrib>SHANG, Cristina</creatorcontrib><creatorcontrib>GERHARD, Rene</creatorcontrib><creatorcontrib>GHOSSEIN, Ronald</creatorcontrib><creatorcontrib>LIN, Oscar</creatorcontrib><title>Anaplastic Thyroid Carcinoma: Morphologic Findings and PAX-8 Expression in Cytology Specimens</title><title>Acta cytologica</title><addtitle>Acta Cytol</addtitle><description>To evaluate the morphologic findings most encountered in anaplastic thyroid carcinomas (ATCs) and evaluate for the expression of PAX-8.
The cytology specimens from 21 cases of ATC were evaluated for the following several cytologic criteria: cell morphology, pleomorphism, presence or absence of multinucleated cells, colloid, neutrophilic infiltrate and well-differentiated component. Immunohistochemical studies for PAX-8 were performed on cell blocks in selected cases.
The most common morphology present was epithelioid, followed by spindle, multinucleated giant cell and rhabdoid, with 75% demonstrating more than 1 cell morphology. Marked pleomorphism (81%), neutrophilic infiltrate (90%) and necrosis (63%) were frequent. No nuclear grooves, colloid or well-differentiated component was identified in any case. Immunocytochemical stains for PAX-8 were negative in 5 cases in which a cell block was available.
ATC is a tumor with diverse morphologic characteristics, and more than 1 cell morphology is usually present. A neutrophilic infiltrate is a common finding and represents a clue to the correct diagnosis.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - pathology</subject><subject>Cytodiagnosis</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Giant Cells - metabolism</subject><subject>Giant Cells - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Paired Box Transcription Factors - metabolism</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>PAX8 Transcription Factor</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>0001-5547</issn><issn>1938-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0F1LwzAUBuAgipvTC_-A5Ea8qua7qXejbCpMFJzgjYw0ybZIm9SkA_vvrTjx6sA5Dy-HF4BzjK4x5sUNQogSTig6AGNcUJkRwdEhGA97nHHO8hE4SeljUFQIegxGBBVCYk7H4H3qVVur1DkNl9s-BmdgqaJ2PjTqFj6G2G5DHTbDee68cX6ToPIGPk_fMglnX220KbngofOw7Lsf2sOX1mrXWJ9OwdFa1cme7ecEvM5ny_I-WzzdPZTTRdYShrqMYyEMM1TzSgzvIouZ5hJLykyRF1zkJq-YVhJVLNfUGoXWDFWEMGWJtkrSCbj6zW1j-NzZ1K0al7Sta-Vt2KVVLhChZChokBd7uasaa1ZtdI2K_eqvkQFc7oFKWtXrqLx26d9RhqgsOP0GnVxtlg</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>RIVERA, Michael</creator><creator>SHANG, Cristina</creator><creator>GERHARD, Rene</creator><creator>GHOSSEIN, Ronald</creator><creator>LIN, Oscar</creator><general>Karger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Anaplastic Thyroid Carcinoma: Morphologic Findings and PAX-8 Expression in Cytology Specimens</title><author>RIVERA, Michael ; SHANG, Cristina ; GERHARD, Rene ; GHOSSEIN, Ronald ; LIN, Oscar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-5166d4d3c5b65540e14c581834d979567d7b4ca80b47c3eda0f40b224ae2cea83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Fine-Needle</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - pathology</topic><topic>Cytodiagnosis</topic><topic>Diagnosis, Differential</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Giant Cells - metabolism</topic><topic>Giant Cells - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Paired Box Transcription Factors - metabolism</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>PAX8 Transcription Factor</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIVERA, Michael</creatorcontrib><creatorcontrib>SHANG, Cristina</creatorcontrib><creatorcontrib>GERHARD, Rene</creatorcontrib><creatorcontrib>GHOSSEIN, Ronald</creatorcontrib><creatorcontrib>LIN, Oscar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cytologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIVERA, Michael</au><au>SHANG, Cristina</au><au>GERHARD, Rene</au><au>GHOSSEIN, Ronald</au><au>LIN, Oscar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaplastic Thyroid Carcinoma: Morphologic Findings and PAX-8 Expression in Cytology Specimens</atitle><jtitle>Acta cytologica</jtitle><addtitle>Acta Cytol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>54</volume><issue>5</issue><spage>668</spage><epage>672</epage><pages>668-672</pages><issn>0001-5547</issn><eissn>1938-2650</eissn><coden>ACYTAN</coden><abstract>To evaluate the morphologic findings most encountered in anaplastic thyroid carcinomas (ATCs) and evaluate for the expression of PAX-8.
The cytology specimens from 21 cases of ATC were evaluated for the following several cytologic criteria: cell morphology, pleomorphism, presence or absence of multinucleated cells, colloid, neutrophilic infiltrate and well-differentiated component. Immunohistochemical studies for PAX-8 were performed on cell blocks in selected cases.
The most common morphology present was epithelioid, followed by spindle, multinucleated giant cell and rhabdoid, with 75% demonstrating more than 1 cell morphology. Marked pleomorphism (81%), neutrophilic infiltrate (90%) and necrosis (63%) were frequent. No nuclear grooves, colloid or well-differentiated component was identified in any case. Immunocytochemical stains for PAX-8 were negative in 5 cases in which a cell block was available.
ATC is a tumor with diverse morphologic characteristics, and more than 1 cell morphology is usually present. A neutrophilic infiltrate is a common finding and represents a clue to the correct diagnosis.</abstract><cop>Basel</cop><pub>Karger</pub><pmid>20968153</pmid><doi>10.1159/000325230</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Karger Journals |
| subjects | Aged Biological and medical sciences Biopsy, Fine-Needle Carcinoma - metabolism Carcinoma - pathology Cytodiagnosis Diagnosis, Differential Endocrinopathies Female Giant Cells - metabolism Giant Cells - pathology Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Male Malignant tumors Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Paired Box Transcription Factors - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques PAX8 Transcription Factor Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) |
| title | Anaplastic Thyroid Carcinoma: Morphologic Findings and PAX-8 Expression in Cytology Specimens |
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