High-mobility group box 1-mediated matrix metalloproteinase-9 expression in non-small cell lung cancer contributes to tumor cell invasiveness

High-mobility group box 1 (HMGB1) is a versatile protein with intranuclear and extracellular functions. It is involved in invasion and metastasis in various human malignancies. However, the role of HMGB1 in non-small cell lung cancer (NSCLC) is unclear. We hypothesized that HMGB1 expression is a det...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2010-11, Vol.43 (5), p.530-538
Hauptverfasser:	Liu, Po-Len, Tsai, Jong-Rung, Hwang, Jhi-Jhu, Chou, Shah-Hwa, Cheng, Yu-Jen, Lin, Feng-Yen, Chen, Yuh-Lien, Hung, Chun-Ying, Chen, Wen-Chi, Chen, Yung-Hsiang, Chong, Inn-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Movement Enzyme Activation Female Gene Expression Regulation, Neoplastic Gene Silencing HMGB1 Protein - genetics HMGB1 Protein - metabolism Humans Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - pathology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Middle Aged Mitogen-Activated Protein Kinases - metabolism Neoplasm Invasiveness NF-kappa B Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism
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