Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

A major theory of aging is that oxidative damage may accumulate in DNA and contribute to physiological changes associated with aging. We examined age‐related accumulation of oxidative damage to both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) in human brain tissue. We measured the oxidized nucl...

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Veröffentlicht in:	Annals of neurology 1993-10, Vol.34 (4), p.609-616
Hauptverfasser:	Mecocci, Patrizia, MacGarvey, Usha, Kaufman, Allan E., Koontz, Deborah, Shoffner, John M., Wallace, Douglas C., Beal, M. Flint
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging - metabolism Biological and medical sciences Brain - metabolism Cell Nucleus - metabolism Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Development. Metamorphosis. Moult. Ageing DNA - metabolism DNA, Mitochondrial - metabolism Female Fundamental and applied biological sciences. Psychology Humans Male Middle Aged Oxidation-Reduction Vertebrates: anatomy and physiology, studies on body, several organs or systems
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