Regulation of Hypoxia Inducible Factors (HIF) in Hypoxia and Normoxia During Placental Development

Abstract During the first trimester of pregnancy the human placenta develops in an hypoxic environment caused by the occlusion of uterine spiral arterioles by extravillous trophoblasts (EVT). This period of low oxygen tension is crucial for successful pregnancy. In low oxygen environments, Hypoxia I...

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Veröffentlicht in:	Placenta (Eastbourne) 2010-11, Vol.31 (11), p.951-957
Hauptverfasser:	Patel, J, Landers, K, Mortimer, R.H, Richard, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Receptor Nuclear Translocator - genetics Aryl Hydrocarbon Receptor Nuclear Translocator - physiology Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology Biological and medical sciences Cell Hypoxia - physiology Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Humans Hypoxia inducible factor Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - physiology Internal Medicine Obstetrics and Gynecology Oxygen Placenta Placentation - physiology Pregnancy Signal Transduction Trophoblast
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