Hairy‐cell leukemia with hybrid B‐T features: A study with a panel of monoclonal antibodies
The peripheral blood of three patients with otherwise typical hairy‐cell leukemia (HCL), but with a substantial number of circulating cells expressing both light chain restricted surface immunoglobulin (SIg) and sheep erythrocyte (E) receptor, was studied with a panel of monoclonal antibodies. The p...
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| Veröffentlicht in: | American journal of hematology 1985-04, Vol.18 (4), p.335-344 |
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| container_end_page | 344 |
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| container_title | American journal of hematology |
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| creator | Armitage, R. J. Worman, C. P. Galvin, M. C. Cawley, J. C. |
| description | The peripheral blood of three patients with otherwise typical hairy‐cell leukemia (HCL), but with a substantial number of circulating cells expressing both light chain restricted surface immunoglobulin (SIg) and sheep erythrocyte (E) receptor, was studied with a panel of monoclonal antibodies. The presence of hybrid B‐T surface features was confirmed and, although as in previous studies of E+SIg+ proliferations, the precise phenotypes varied at different times of study, E+ non‐T SIg+ and E+T+SIg+ populations were at times present in all three patients together with typical B hairy‐cell (HC) and phenotypically normal T‐cell populations. In one patient an E−OKT11+SIg+ population was also observed. Extensive precautions were taken to exclude spurious explanations for these hybrid phenotypes. These results are discussed in relation to the recent demonstration that both HCs and normal B cells can express T‐cell features after appropriate in vitro stimulation. |
| doi_str_mv | 10.1002/ajh.2830180402 |
| format | Article |
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J. ; Worman, C. P. ; Galvin, M. C. ; Cawley, J. C.</creator><creatorcontrib>Armitage, R. J. ; Worman, C. P. ; Galvin, M. C. ; Cawley, J. C.</creatorcontrib><description>The peripheral blood of three patients with otherwise typical hairy‐cell leukemia (HCL), but with a substantial number of circulating cells expressing both light chain restricted surface immunoglobulin (SIg) and sheep erythrocyte (E) receptor, was studied with a panel of monoclonal antibodies. The presence of hybrid B‐T surface features was confirmed and, although as in previous studies of E+SIg+ proliferations, the precise phenotypes varied at different times of study, E+ non‐T SIg+ and E+T+SIg+ populations were at times present in all three patients together with typical B hairy‐cell (HC) and phenotypically normal T‐cell populations. In one patient an E−OKT11+SIg+ population was also observed. Extensive precautions were taken to exclude spurious explanations for these hybrid phenotypes. These results are discussed in relation to the recent demonstration that both HCs and normal B cells can express T‐cell features after appropriate in vitro stimulation.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.2830180402</identifier><identifier>PMID: 3883757</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Antibodies, Monoclonal ; Antigen-Presenting Cells - immunology ; B-Lymphocytes - immunology ; Biological and medical sciences ; B‐T cells ; Erythrocytes - immunology ; Fluorescent Antibody Technique ; hairy‐cell leukemia ; Hematologic and hematopoietic diseases ; Humans ; Immunoglobulin A, Secretory - analysis ; Leukemia, Hairy Cell - immunology ; Leukemia, Hairy Cell - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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J.</creatorcontrib><creatorcontrib>Worman, C. P.</creatorcontrib><creatorcontrib>Galvin, M. C.</creatorcontrib><creatorcontrib>Cawley, J. C.</creatorcontrib><title>Hairy‐cell leukemia with hybrid B‐T features: A study with a panel of monoclonal antibodies</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>The peripheral blood of three patients with otherwise typical hairy‐cell leukemia (HCL), but with a substantial number of circulating cells expressing both light chain restricted surface immunoglobulin (SIg) and sheep erythrocyte (E) receptor, was studied with a panel of monoclonal antibodies. The presence of hybrid B‐T surface features was confirmed and, although as in previous studies of E+SIg+ proliferations, the precise phenotypes varied at different times of study, E+ non‐T SIg+ and E+T+SIg+ populations were at times present in all three patients together with typical B hairy‐cell (HC) and phenotypically normal T‐cell populations. In one patient an E−OKT11+SIg+ population was also observed. Extensive precautions were taken to exclude spurious explanations for these hybrid phenotypes. These results are discussed in relation to the recent demonstration that both HCs and normal B cells can express T‐cell features after appropriate in vitro stimulation.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>B‐T cells</subject><subject>Erythrocytes - immunology</subject><subject>Fluorescent Antibody Technique</subject><subject>hairy‐cell leukemia</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoglobulin A, Secretory - analysis</subject><subject>Leukemia, Hairy Cell - immunology</subject><subject>Leukemia, Hairy Cell - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Monocytes - immunology</subject><subject>Receptors, Immunologic - analysis</subject><subject>Rosette Formation</subject><subject>Sheep</subject><subject>T-Lymphocytes - immunology</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLFu2zAQhokiReqmXbsV4BB0s3skJYrs5gRpnCJAF-_EiaJgppTkkhICbXmEPmOeJExspN063QH_d3f__YR8YrBiAPwr3u1WXAlgCgrgb8iCgZZLJUt-QhYgJMs96HfkfUp3AIwVCk7JqVBKVGW1IGaDPs6PD3-sC4EGN_1ynUd678cd3c119A29yOqWtg7HKbr0ja5pGqdmPjBI99i7QIeWdkM_2DD0GCj2o6-Hxrv0gbxtMST38VjPyPb71fZys7z9eX1zub5dWiE1X9bcatRMKqVaK6yysmxLzQA5t1CiklKgaFhVNJIzy-tSC9dWgksoCs6YOCNfDmv3cfg9uTSazqfnl7K5YUqmkpAxVmZwdQBtHFKKrjX76DuMs2FgngM1OVDzN9A88Pm4eao717zixwSzfn7UMVkMbcTe-vSKachfvRjUB-zeBzf_56hZ_9j8Y-EJ6jKOxA</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>Armitage, R. J.</creator><creator>Worman, C. P.</creator><creator>Galvin, M. C.</creator><creator>Cawley, J. C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198504</creationdate><title>Hairy‐cell leukemia with hybrid B‐T features: A study with a panel of monoclonal antibodies</title><author>Armitage, R. J. ; Worman, C. P. ; Galvin, M. C. ; Cawley, J. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3692-b2c9a916888fc3c8c65f5910a22c05a8663a3d174d621c2b593ef73260442113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>B‐T cells</topic><topic>Erythrocytes - immunology</topic><topic>Fluorescent Antibody Technique</topic><topic>hairy‐cell leukemia</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoglobulin A, Secretory - analysis</topic><topic>Leukemia, Hairy Cell - immunology</topic><topic>Leukemia, Hairy Cell - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Monocytes - immunology</topic><topic>Receptors, Immunologic - analysis</topic><topic>Rosette Formation</topic><topic>Sheep</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armitage, R. J.</creatorcontrib><creatorcontrib>Worman, C. P.</creatorcontrib><creatorcontrib>Galvin, M. C.</creatorcontrib><creatorcontrib>Cawley, J. C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armitage, R. J.</au><au>Worman, C. P.</au><au>Galvin, M. C.</au><au>Cawley, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hairy‐cell leukemia with hybrid B‐T features: A study with a panel of monoclonal antibodies</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>1985-04</date><risdate>1985</risdate><volume>18</volume><issue>4</issue><spage>335</spage><epage>344</epage><pages>335-344</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>The peripheral blood of three patients with otherwise typical hairy‐cell leukemia (HCL), but with a substantial number of circulating cells expressing both light chain restricted surface immunoglobulin (SIg) and sheep erythrocyte (E) receptor, was studied with a panel of monoclonal antibodies. The presence of hybrid B‐T surface features was confirmed and, although as in previous studies of E+SIg+ proliferations, the precise phenotypes varied at different times of study, E+ non‐T SIg+ and E+T+SIg+ populations were at times present in all three patients together with typical B hairy‐cell (HC) and phenotypically normal T‐cell populations. In one patient an E−OKT11+SIg+ population was also observed. Extensive precautions were taken to exclude spurious explanations for these hybrid phenotypes. These results are discussed in relation to the recent demonstration that both HCs and normal B cells can express T‐cell features after appropriate in vitro stimulation.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3883757</pmid><doi>10.1002/ajh.2830180402</doi><tpages>10</tpages></addata></record> |
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| ispartof | American journal of hematology, 1985-04, Vol.18 (4), p.335-344 |
| issn | 0361-8609 1096-8652 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antibodies, Monoclonal Antigen-Presenting Cells - immunology B-Lymphocytes - immunology Biological and medical sciences B‐T cells Erythrocytes - immunology Fluorescent Antibody Technique hairy‐cell leukemia Hematologic and hematopoietic diseases Humans Immunoglobulin A, Secretory - analysis Leukemia, Hairy Cell - immunology Leukemia, Hairy Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Monocytes - immunology Receptors, Immunologic - analysis Rosette Formation Sheep T-Lymphocytes - immunology |
| title | Hairy‐cell leukemia with hybrid B‐T features: A study with a panel of monoclonal antibodies |
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