Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro

Addition of transforming growth factor-beta 1 (TGF-beta 1) to in vitro cultures of murine B cells activated with bacterial LPS selectively stimulates IgG2b and IgA class switching and decreases cellular proliferation. To assess a possible role for endogenous TGF-beta in modulating the Ig isotypes pr...

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Veröffentlicht in:	The Journal of immunology (1950) 1993-11, Vol.151 (9), p.4625-4636
Hauptverfasser:	Snapper, CM, Waegell, W, Beernink, H, Dasch, JR
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism Cells, Cultured Female Immunoglobulin Class Switching Immunoglobulin G - biosynthesis Immunoglobulin G - classification Interferon-gamma - pharmacology Interleukin-4 - pharmacology Lipopolysaccharides - pharmacology Lymphocyte Activation Mice Mice, Inbred DBA Transforming Growth Factor beta - physiology
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