Lipidomics era: Accomplishments and challenges
Lipid mediators participate in signal transduction pathways, proliferation, apoptosis, and membrane trafficking in the cell. Lipids are highly complex and diverse owing to the various combinations of polar headgroups, fatty acyl chains, and backbone structures. This structural diversity continues to...
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| Veröffentlicht in: | Mass spectrometry reviews 2010-11, Vol.29 (6), p.877-929 |
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| container_title | Mass spectrometry reviews |
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| creator | Bou Khalil, Maroun Hou, Weimin Zhou, Hu Elisma, Fred Swayne, Leigh Anne Blanchard, Alexandre P Yao, Zemin Bennett, Steffany A.L Figeys, Daniel |
| description | Lipid mediators participate in signal transduction pathways, proliferation, apoptosis, and membrane trafficking in the cell. Lipids are highly complex and diverse owing to the various combinations of polar headgroups, fatty acyl chains, and backbone structures. This structural diversity continues to pose a challenge for lipid analysis. Here we review the current state of the art in lipidomics research and discuss the challenges facing this field. The latest technological developments in mass spectrometry, the role of bioinformatics, and the applications of lipidomics in lipid metabolism and cellular physiology and pathology are also discussed. |
| doi_str_mv | 10.1002/mas.20294 |
| format | Article |
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Lipids are highly complex and diverse owing to the various combinations of polar headgroups, fatty acyl chains, and backbone structures. This structural diversity continues to pose a challenge for lipid analysis. Here we review the current state of the art in lipidomics research and discuss the challenges facing this field. The latest technological developments in mass spectrometry, the role of bioinformatics, and the applications of lipidomics in lipid metabolism and cellular physiology and pathology are also discussed.</description><identifier>ISSN: 0277-7037</identifier><identifier>EISSN: 1098-2787</identifier><identifier>DOI: 10.1002/mas.20294</identifier><identifier>PMID: 20931646</identifier><identifier>CODEN: MSRVD3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Analytical, structural and metabolic biochemistry ; Apoptosis ; Bioinformatics ; Biological and medical sciences ; Cell Membrane - ultrastructure ; Cell Physiological Phenomena ; Computational Biology ; Fats, Unsaturated - chemistry ; Fundamental and applied biological sciences. Psychology ; Homeostasis ; Humans ; Hydrocarbons - chemistry ; identification ; Lipid metabolism ; Lipid Metabolism - genetics ; Lipid Metabolism - physiology ; lipidomics ; Lipids ; Lipids - chemistry ; Lipids - physiology ; Mass Spectrometry - instrumentation ; Mass spectroscopy ; Membrane trafficking ; Metabolomics - methods ; Molecular Conformation ; Other biological molecules ; quantification ; Signal Transduction ; systems biology ; Tandem Mass Spectrometry</subject><ispartof>Mass spectrometry reviews, 2010-11, Vol.29 (6), p.877-929</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>2010 Wiley Periodicals, Inc.</rights><rights>Copyright Wiley Subscription Services, Inc. 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Rev</addtitle><description>Lipid mediators participate in signal transduction pathways, proliferation, apoptosis, and membrane trafficking in the cell. Lipids are highly complex and diverse owing to the various combinations of polar headgroups, fatty acyl chains, and backbone structures. This structural diversity continues to pose a challenge for lipid analysis. Here we review the current state of the art in lipidomics research and discuss the challenges facing this field. The latest technological developments in mass spectrometry, the role of bioinformatics, and the applications of lipidomics in lipid metabolism and cellular physiology and pathology are also discussed.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Apoptosis</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane - ultrastructure</subject><subject>Cell Physiological Phenomena</subject><subject>Computational Biology</subject><subject>Fats, Unsaturated - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hydrocarbons - chemistry</subject><subject>identification</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipid Metabolism - physiology</subject><subject>lipidomics</subject><subject>Lipids</subject><subject>Lipids - chemistry</subject><subject>Lipids - physiology</subject><subject>Mass Spectrometry - instrumentation</subject><subject>Mass spectroscopy</subject><subject>Membrane trafficking</subject><subject>Metabolomics - methods</subject><subject>Molecular Conformation</subject><subject>Other biological molecules</subject><subject>quantification</subject><subject>Signal Transduction</subject><subject>systems biology</subject><subject>Tandem Mass Spectrometry</subject><issn>0277-7037</issn><issn>1098-2787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtuEzEUBmALgWgoLHgBiISqisWk5_gyHrOLKtqCwkWC0qXleM60LnNJ7UTQt6_DpEVCQl54853bz9hLhBkC8KPOpRkHbuQjNkEwVcF1pR-zCXCtCw1C77FnKV0DICrEp2yPgxFYynLCZouwCvXQBZ-mFN276dz7oVu1IV111K_T1PX11F-5tqX-ktJz9qRxbaIXu3-fnZ-8_358Viy-nH44ni8KrxBk0ZS6IiqpXBpA42RdSyxRiMooT5VTivgyi-2rDaKrK5DLSjSGVGnAodhnh2PfVRxuNpTWtgvJU9u6noZNsroEjqBKneWbf-T1sIl9Xs5yKUCCNJXI6u2ofBxSitTYVQydi7cWwW4ztDlD-yfDbF_tOm6WHdUP8j60DA52wCXv2ia63of01wnJ86nboUej-xVauv3_RPtp_u1-dDFWhLSm3w8VLv60-VSt7MXnU3tyZj5ydfHDfs3-9egbN1h3GfMW57kVipx6TkdqcQeCa51k</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Bou Khalil, Maroun</creator><creator>Hou, Weimin</creator><creator>Zhou, Hu</creator><creator>Elisma, Fred</creator><creator>Swayne, Leigh Anne</creator><creator>Blanchard, Alexandre P</creator><creator>Yao, Zemin</creator><creator>Bennett, Steffany A.L</creator><creator>Figeys, Daniel</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201011</creationdate><title>Lipidomics era: Accomplishments and challenges</title><author>Bou Khalil, Maroun ; Hou, Weimin ; Zhou, Hu ; Elisma, Fred ; Swayne, Leigh Anne ; Blanchard, Alexandre P ; Yao, Zemin ; Bennett, Steffany A.L ; Figeys, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5104-f678ee6e6b9019a4dd416133895ce8a55e2b78e8e8ed911ad804b83f9e5690a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Apoptosis</topic><topic>Bioinformatics</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane - ultrastructure</topic><topic>Cell Physiological Phenomena</topic><topic>Computational Biology</topic><topic>Fats, Unsaturated - chemistry</topic><topic>Fundamental and applied biological sciences. 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| subjects | Analytical, structural and metabolic biochemistry Apoptosis Bioinformatics Biological and medical sciences Cell Membrane - ultrastructure Cell Physiological Phenomena Computational Biology Fats, Unsaturated - chemistry Fundamental and applied biological sciences. Psychology Homeostasis Humans Hydrocarbons - chemistry identification Lipid metabolism Lipid Metabolism - genetics Lipid Metabolism - physiology lipidomics Lipids Lipids - chemistry Lipids - physiology Mass Spectrometry - instrumentation Mass spectroscopy Membrane trafficking Metabolomics - methods Molecular Conformation Other biological molecules quantification Signal Transduction systems biology Tandem Mass Spectrometry |
| title | Lipidomics era: Accomplishments and challenges |
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