Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations

It has been almost a decade since a previously unknown human toxic syndrome, azaspiracid poisoning (AZP), emerged as the cause of severe gastrointestinal illness in humans after the consumption of mussels ( Mytilus edulis). Structural studies indicated that these toxins, azaspiracids, were of a new...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Toxicon (Oxford) 2010-08, Vol.56 (2), p.173-190
Hauptverfasser: Furey, Ambrose, O'Doherty, Sinead, O'Callaghan, Keith, Lehane, Mary, James, Kevin J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 190
container_issue 2
container_start_page 173
container_title Toxicon (Oxford)
container_volume 56
creator Furey, Ambrose
O'Doherty, Sinead
O'Callaghan, Keith
Lehane, Mary
James, Kevin J.
description It has been almost a decade since a previously unknown human toxic syndrome, azaspiracid poisoning (AZP), emerged as the cause of severe gastrointestinal illness in humans after the consumption of mussels ( Mytilus edulis). Structural studies indicated that these toxins, azaspiracids, were of a new unprecedented class containing novel structural features. It is now known that the prevalent azaspiracids in mussels are AZA1, AZA2 and AZA3, which differ from each other in their degree of methylation. Several hydroxylated and carboxylated analogues of the main azaspiracids have also been identified, presumed to be metabolites of the main toxins. Since its first discovery in Irish mussels, the development of facile sensitive and selective LC-MS/MS methods has resulted in the discovery of AZA in other countries and in other species. Mice studies indicate that this toxin class can cause serious tissue injury, especially to the small intestine, and chronic exposure may increase the likelihood of the development of lung tumours. Studies also show that tissue recovery is very slow following exposure. These observations suggest that AZA is more dangerous than the other known classes of shellfish toxins. Consequently, in order to protect human consumers, proper risk assessment and regulatory control of shellfish and other affected species is of the utmost importance.
doi_str_mv 10.1016/j.toxicon.2009.09.009
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_760207217</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0041010109004607</els_id><sourcerecordid>760207217</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-68f72e212bfddb4e6d33e447f41192ec3d56a51905c43c04790b56225b550293</originalsourceid><addsrcrecordid>eNqFkE1PGzEQhq2qVQm0P6HIt8Jh07F37Y25VBHiS0JqDzkgLpbXniWONutgbyrg19dLAlekkWyNnvEzfgn5wWDKgMlfq-kQnrwN_ZQDqOlYoD6RCZvVqiiZgM9kAlCxAjJ-QA5TWgFAOVPyKznII1zm_oTczV9M2vhorHd0E3wKve8f6Mn8_u8pHQ19or6naYld1_q0PKOLV20XHrw1HTW9o0s03bCkeZfkHUYz-Hz7Rr60pkv4fX8ekcXlxeL8urj9c3VzPr8tbKnkUMhZW3PkjDetc02F0pUlVlXdVowpjrZ0QhrBFAhblRaqWkEjJOeiEQK4Ko_Iz92zmxget5gGvfbJ5mVNj2GbdC2BQ81ZnUmxI20MKUVs9Sb6tYnPmoEeI9UrvY9Uj5HqsWA0HO8N22aN7n3qLcMM_N4BmL_5z2PUyXrsLTof0Q7aBf-B4j9wYopH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>760207217</pqid></control><display><type>article</type><title>Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Furey, Ambrose ; O'Doherty, Sinead ; O'Callaghan, Keith ; Lehane, Mary ; James, Kevin J.</creator><creatorcontrib>Furey, Ambrose ; O'Doherty, Sinead ; O'Callaghan, Keith ; Lehane, Mary ; James, Kevin J.</creatorcontrib><description>It has been almost a decade since a previously unknown human toxic syndrome, azaspiracid poisoning (AZP), emerged as the cause of severe gastrointestinal illness in humans after the consumption of mussels ( Mytilus edulis). Structural studies indicated that these toxins, azaspiracids, were of a new unprecedented class containing novel structural features. It is now known that the prevalent azaspiracids in mussels are AZA1, AZA2 and AZA3, which differ from each other in their degree of methylation. Several hydroxylated and carboxylated analogues of the main azaspiracids have also been identified, presumed to be metabolites of the main toxins. Since its first discovery in Irish mussels, the development of facile sensitive and selective LC-MS/MS methods has resulted in the discovery of AZA in other countries and in other species. Mice studies indicate that this toxin class can cause serious tissue injury, especially to the small intestine, and chronic exposure may increase the likelihood of the development of lung tumours. Studies also show that tissue recovery is very slow following exposure. These observations suggest that AZA is more dangerous than the other known classes of shellfish toxins. Consequently, in order to protect human consumers, proper risk assessment and regulatory control of shellfish and other affected species is of the utmost importance.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/j.toxicon.2009.09.009</identifier><identifier>PMID: 20026101</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Azaspiracids ; AZP ; Cell Line, Tumor ; Cell Survival - drug effects ; Chromatography, High Pressure Liquid ; Foodborne Diseases ; Human ; Humans ; Intestine, Small - drug effects ; Intestine, Small - ultrastructure ; LC-MS ; Lung Neoplasms - chemically induced ; Lung Neoplasms - pathology ; Marine ; Marine toxins ; Marine Toxins - chemistry ; Marine Toxins - poisoning ; Metabolites ; Methylation ; Mice ; Microscopy, Electron, Scanning ; Molecular Structure ; Mussels ; Mytilus edulis ; Mytilus edulis - chemistry ; Mytilus edulis - metabolism ; Neurons - drug effects ; Neurons - pathology ; Poisoning ; Shellfish ; Shellfish Poisoning - etiology ; Shellfish Poisoning - metabolism ; Spectrometry, Mass, Electrospray Ionization ; Spiro Compounds - chemistry ; Spiro Compounds - poisoning ; Tandem Mass Spectrometry ; Toxicity Tests ; Toxins ; Tumours</subject><ispartof>Toxicon (Oxford), 2010-08, Vol.56 (2), p.173-190</ispartof><rights>2009</rights><rights>Copyright 2009. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-68f72e212bfddb4e6d33e447f41192ec3d56a51905c43c04790b56225b550293</citedby><cites>FETCH-LOGICAL-c396t-68f72e212bfddb4e6d33e447f41192ec3d56a51905c43c04790b56225b550293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxicon.2009.09.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20026101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furey, Ambrose</creatorcontrib><creatorcontrib>O'Doherty, Sinead</creatorcontrib><creatorcontrib>O'Callaghan, Keith</creatorcontrib><creatorcontrib>Lehane, Mary</creatorcontrib><creatorcontrib>James, Kevin J.</creatorcontrib><title>Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>It has been almost a decade since a previously unknown human toxic syndrome, azaspiracid poisoning (AZP), emerged as the cause of severe gastrointestinal illness in humans after the consumption of mussels ( Mytilus edulis). Structural studies indicated that these toxins, azaspiracids, were of a new unprecedented class containing novel structural features. It is now known that the prevalent azaspiracids in mussels are AZA1, AZA2 and AZA3, which differ from each other in their degree of methylation. Several hydroxylated and carboxylated analogues of the main azaspiracids have also been identified, presumed to be metabolites of the main toxins. Since its first discovery in Irish mussels, the development of facile sensitive and selective LC-MS/MS methods has resulted in the discovery of AZA in other countries and in other species. Mice studies indicate that this toxin class can cause serious tissue injury, especially to the small intestine, and chronic exposure may increase the likelihood of the development of lung tumours. Studies also show that tissue recovery is very slow following exposure. These observations suggest that AZA is more dangerous than the other known classes of shellfish toxins. Consequently, in order to protect human consumers, proper risk assessment and regulatory control of shellfish and other affected species is of the utmost importance.</description><subject>Animals</subject><subject>Azaspiracids</subject><subject>AZP</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Foodborne Diseases</subject><subject>Human</subject><subject>Humans</subject><subject>Intestine, Small - drug effects</subject><subject>Intestine, Small - ultrastructure</subject><subject>LC-MS</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - pathology</subject><subject>Marine</subject><subject>Marine toxins</subject><subject>Marine Toxins - chemistry</subject><subject>Marine Toxins - poisoning</subject><subject>Metabolites</subject><subject>Methylation</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Structure</subject><subject>Mussels</subject><subject>Mytilus edulis</subject><subject>Mytilus edulis - chemistry</subject><subject>Mytilus edulis - metabolism</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Poisoning</subject><subject>Shellfish</subject><subject>Shellfish Poisoning - etiology</subject><subject>Shellfish Poisoning - metabolism</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Spiro Compounds - chemistry</subject><subject>Spiro Compounds - poisoning</subject><subject>Tandem Mass Spectrometry</subject><subject>Toxicity Tests</subject><subject>Toxins</subject><subject>Tumours</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2qVQm0P6HIt8Jh07F37Y25VBHiS0JqDzkgLpbXniWONutgbyrg19dLAlekkWyNnvEzfgn5wWDKgMlfq-kQnrwN_ZQDqOlYoD6RCZvVqiiZgM9kAlCxAjJ-QA5TWgFAOVPyKznII1zm_oTczV9M2vhorHd0E3wKve8f6Mn8_u8pHQ19or6naYld1_q0PKOLV20XHrw1HTW9o0s03bCkeZfkHUYz-Hz7Rr60pkv4fX8ekcXlxeL8urj9c3VzPr8tbKnkUMhZW3PkjDetc02F0pUlVlXdVowpjrZ0QhrBFAhblRaqWkEjJOeiEQK4Ko_Iz92zmxget5gGvfbJ5mVNj2GbdC2BQ81ZnUmxI20MKUVs9Sb6tYnPmoEeI9UrvY9Uj5HqsWA0HO8N22aN7n3qLcMM_N4BmL_5z2PUyXrsLTof0Q7aBf-B4j9wYopH</recordid><startdate>20100815</startdate><enddate>20100815</enddate><creator>Furey, Ambrose</creator><creator>O'Doherty, Sinead</creator><creator>O'Callaghan, Keith</creator><creator>Lehane, Mary</creator><creator>James, Kevin J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20100815</creationdate><title>Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations</title><author>Furey, Ambrose ; O'Doherty, Sinead ; O'Callaghan, Keith ; Lehane, Mary ; James, Kevin J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-68f72e212bfddb4e6d33e447f41192ec3d56a51905c43c04790b56225b550293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Azaspiracids</topic><topic>AZP</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Foodborne Diseases</topic><topic>Human</topic><topic>Humans</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - ultrastructure</topic><topic>LC-MS</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - pathology</topic><topic>Marine</topic><topic>Marine toxins</topic><topic>Marine Toxins - chemistry</topic><topic>Marine Toxins - poisoning</topic><topic>Metabolites</topic><topic>Methylation</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molecular Structure</topic><topic>Mussels</topic><topic>Mytilus edulis</topic><topic>Mytilus edulis - chemistry</topic><topic>Mytilus edulis - metabolism</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Poisoning</topic><topic>Shellfish</topic><topic>Shellfish Poisoning - etiology</topic><topic>Shellfish Poisoning - metabolism</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Spiro Compounds - chemistry</topic><topic>Spiro Compounds - poisoning</topic><topic>Tandem Mass Spectrometry</topic><topic>Toxicity Tests</topic><topic>Toxins</topic><topic>Tumours</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furey, Ambrose</creatorcontrib><creatorcontrib>O'Doherty, Sinead</creatorcontrib><creatorcontrib>O'Callaghan, Keith</creatorcontrib><creatorcontrib>Lehane, Mary</creatorcontrib><creatorcontrib>James, Kevin J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furey, Ambrose</au><au>O'Doherty, Sinead</au><au>O'Callaghan, Keith</au><au>Lehane, Mary</au><au>James, Kevin J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2010-08-15</date><risdate>2010</risdate><volume>56</volume><issue>2</issue><spage>173</spage><epage>190</epage><pages>173-190</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><abstract>It has been almost a decade since a previously unknown human toxic syndrome, azaspiracid poisoning (AZP), emerged as the cause of severe gastrointestinal illness in humans after the consumption of mussels ( Mytilus edulis). Structural studies indicated that these toxins, azaspiracids, were of a new unprecedented class containing novel structural features. It is now known that the prevalent azaspiracids in mussels are AZA1, AZA2 and AZA3, which differ from each other in their degree of methylation. Several hydroxylated and carboxylated analogues of the main azaspiracids have also been identified, presumed to be metabolites of the main toxins. Since its first discovery in Irish mussels, the development of facile sensitive and selective LC-MS/MS methods has resulted in the discovery of AZA in other countries and in other species. Mice studies indicate that this toxin class can cause serious tissue injury, especially to the small intestine, and chronic exposure may increase the likelihood of the development of lung tumours. Studies also show that tissue recovery is very slow following exposure. These observations suggest that AZA is more dangerous than the other known classes of shellfish toxins. Consequently, in order to protect human consumers, proper risk assessment and regulatory control of shellfish and other affected species is of the utmost importance.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20026101</pmid><doi>10.1016/j.toxicon.2009.09.009</doi><tpages>18</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0041-0101
ispartof Toxicon (Oxford), 2010-08, Vol.56 (2), p.173-190
issn 0041-0101
1879-3150
language eng
recordid cdi_proquest_miscellaneous_760207217
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Animals
Azaspiracids
AZP
Cell Line, Tumor
Cell Survival - drug effects
Chromatography, High Pressure Liquid
Foodborne Diseases
Human
Humans
Intestine, Small - drug effects
Intestine, Small - ultrastructure
LC-MS
Lung Neoplasms - chemically induced
Lung Neoplasms - pathology
Marine
Marine toxins
Marine Toxins - chemistry
Marine Toxins - poisoning
Metabolites
Methylation
Mice
Microscopy, Electron, Scanning
Molecular Structure
Mussels
Mytilus edulis
Mytilus edulis - chemistry
Mytilus edulis - metabolism
Neurons - drug effects
Neurons - pathology
Poisoning
Shellfish
Shellfish Poisoning - etiology
Shellfish Poisoning - metabolism
Spectrometry, Mass, Electrospray Ionization
Spiro Compounds - chemistry
Spiro Compounds - poisoning
Tandem Mass Spectrometry
Toxicity Tests
Toxins
Tumours
title Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T01%3A51%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Azaspiracid%20poisoning%20(AZP)%20toxins%20in%20shellfish:%20Toxicological%20and%20health%20considerations&rft.jtitle=Toxicon%20(Oxford)&rft.au=Furey,%20Ambrose&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=173&rft.epage=190&rft.pages=173-190&rft.issn=0041-0101&rft.eissn=1879-3150&rft_id=info:doi/10.1016/j.toxicon.2009.09.009&rft_dat=%3Cproquest_cross%3E760207217%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=760207217&rft_id=info:pmid/20026101&rft_els_id=S0041010109004607&rfr_iscdi=true