Oxidative stress parameters in rats exposed to fluoride and caffeine
In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thir...
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| Veröffentlicht in: | Food and chemical toxicology 2010-06, Vol.48 (6), p.1607-1611 |
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| creator | Inkielewicz-Stepniak, I. Czarnowski, W. |
| description | In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls drinking tap water; (II) controls drinking tap water and receiving intragastrically 0.5ml of tap water; (III) animals receiving 25mgF/L in drinking water; (IV) animals receiving 4.7mgCaff/kgbw/day; (V) animals receiving 25mgF/L in drinking water and 4.7mgCaff/kgbw/day. The applied fluoride caused increase of nitric oxide level (NO), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver. Caffeine administered intragastrically, as an antioxidant, was relatively efficient in alleviating these adverse effects of F. In rats treated only with fluoride the F excretion in urine significantly increased in an exposure-time dependent-manner and did not change both in rats treated with Caff and co-exposed to Caff and F. |
| doi_str_mv | 10.1016/j.fct.2010.03.033 |
| format | Article |
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Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls drinking tap water; (II) controls drinking tap water and receiving intragastrically 0.5ml of tap water; (III) animals receiving 25mgF/L in drinking water; (IV) animals receiving 4.7mgCaff/kgbw/day; (V) animals receiving 25mgF/L in drinking water and 4.7mgCaff/kgbw/day. The applied fluoride caused increase of nitric oxide level (NO), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver. Caffeine administered intragastrically, as an antioxidant, was relatively efficient in alleviating these adverse effects of F. In rats treated only with fluoride the F excretion in urine significantly increased in an exposure-time dependent-manner and did not change both in rats treated with Caff and co-exposed to Caff and F.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2010.03.033</identifier><identifier>PMID: 20347920</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>adults ; adverse effects ; Animals ; antioxidants ; Biological and medical sciences ; blood serum ; brain ; caffeine ; Caffeine - toxicity ; drinking ; excretion ; Fluoride and caffeine ; Fluoride in urine ; Fluorides - toxicity ; kidneys ; Lipid peroxidation ; liver ; Male ; Male rats ; Medical sciences ; Nitric oxide ; Oxidative Stress ; Rats ; Rats, Wistar ; tap water ; Thiobarbituric Acid Reactive Substances ; Total antioxidant potential ; Toxicology ; urine ; Water Supply</subject><ispartof>Food and chemical toxicology, 2010-06, Vol.48 (6), p.1607-1611</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-7c90a08acdd6381e476fc91f527aac52f6be4073b650981586eef6d2eb4a4c513</citedby><cites>FETCH-LOGICAL-c481t-7c90a08acdd6381e476fc91f527aac52f6be4073b650981586eef6d2eb4a4c513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691510001821$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22834339$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20347920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inkielewicz-Stepniak, I.</creatorcontrib><creatorcontrib>Czarnowski, W.</creatorcontrib><title>Oxidative stress parameters in rats exposed to fluoride and caffeine</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls drinking tap water; (II) controls drinking tap water and receiving intragastrically 0.5ml of tap water; (III) animals receiving 25mgF/L in drinking water; (IV) animals receiving 4.7mgCaff/kgbw/day; (V) animals receiving 25mgF/L in drinking water and 4.7mgCaff/kgbw/day. The applied fluoride caused increase of nitric oxide level (NO), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver. Caffeine administered intragastrically, as an antioxidant, was relatively efficient in alleviating these adverse effects of F. In rats treated only with fluoride the F excretion in urine significantly increased in an exposure-time dependent-manner and did not change both in rats treated with Caff and co-exposed to Caff and F.</description><subject>adults</subject><subject>adverse effects</subject><subject>Animals</subject><subject>antioxidants</subject><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>brain</subject><subject>caffeine</subject><subject>Caffeine - toxicity</subject><subject>drinking</subject><subject>excretion</subject><subject>Fluoride and caffeine</subject><subject>Fluoride in urine</subject><subject>Fluorides - toxicity</subject><subject>kidneys</subject><subject>Lipid peroxidation</subject><subject>liver</subject><subject>Male</subject><subject>Male rats</subject><subject>Medical sciences</subject><subject>Nitric oxide</subject><subject>Oxidative Stress</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>tap water</subject><subject>Thiobarbituric Acid Reactive Substances</subject><subject>Total antioxidant potential</subject><subject>Toxicology</subject><subject>urine</subject><subject>Water Supply</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MFqGzEQBmARWhon6QPk0upSclp3JK2kXXoKaZMWAjk0OYuxNCoy611XWof07atgt7kFRgjBN6PhZ-xcwFKAMJ_Xy-jnpYT6BlVLHbGF6KxqjNLiDVuAtF1jeqGP2UkpawCwwpp37FiCam0vYcG-3j2lgHN6JF7mTKXwLWbc0Ey58DTyjHPh9LSdCgU-TzwOuymnQBzHwD3GSGmkM_Y24lDo_eE-ZQ_X3-6vvje3dzc_ri5vG992Ym6s7wGhQx-CUZ2g1proexG1tIhey2hW1IJVK6Oh74TuDFE0QdKqxdZroU7ZxX7uNk-_d1Rmt0nF0zDgSNOuOGtAghEGqhR76fNUSqbotjltMP9xAtxzdm7tanbuOTsHqpaqPR8O03erDYX_Hf_CquDTAWDxOMSMo0_lxclOtUr11X3cu4iTw1-5moef9ScN9ahWyyq-7AXVtB4TZVd8otFTSJnqWmFKryz6FzKWlMU</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Inkielewicz-Stepniak, I.</creator><creator>Czarnowski, W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20100601</creationdate><title>Oxidative stress parameters in rats exposed to fluoride and caffeine</title><author>Inkielewicz-Stepniak, I. ; Czarnowski, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-7c90a08acdd6381e476fc91f527aac52f6be4073b650981586eef6d2eb4a4c513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>adults</topic><topic>adverse effects</topic><topic>Animals</topic><topic>antioxidants</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>brain</topic><topic>caffeine</topic><topic>Caffeine - toxicity</topic><topic>drinking</topic><topic>excretion</topic><topic>Fluoride and caffeine</topic><topic>Fluoride in urine</topic><topic>Fluorides - toxicity</topic><topic>kidneys</topic><topic>Lipid peroxidation</topic><topic>liver</topic><topic>Male</topic><topic>Male rats</topic><topic>Medical sciences</topic><topic>Nitric oxide</topic><topic>Oxidative Stress</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>tap water</topic><topic>Thiobarbituric Acid Reactive Substances</topic><topic>Total antioxidant potential</topic><topic>Toxicology</topic><topic>urine</topic><topic>Water Supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inkielewicz-Stepniak, I.</creatorcontrib><creatorcontrib>Czarnowski, W.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inkielewicz-Stepniak, I.</au><au>Czarnowski, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress parameters in rats exposed to fluoride and caffeine</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>48</volume><issue>6</issue><spage>1607</spage><epage>1611</epage><pages>1607-1611</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated. Also, the influence of caffeine on fluoride excretion with urine was studied. Thirty adult male Wistar rats were divided into five equal groups of six each: (I) controls drinking tap water; (II) controls drinking tap water and receiving intragastrically 0.5ml of tap water; (III) animals receiving 25mgF/L in drinking water; (IV) animals receiving 4.7mgCaff/kgbw/day; (V) animals receiving 25mgF/L in drinking water and 4.7mgCaff/kgbw/day. The applied fluoride caused increase of nitric oxide level (NO), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver. Caffeine administered intragastrically, as an antioxidant, was relatively efficient in alleviating these adverse effects of F. In rats treated only with fluoride the F excretion in urine significantly increased in an exposure-time dependent-manner and did not change both in rats treated with Caff and co-exposed to Caff and F.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>20347920</pmid><doi>10.1016/j.fct.2010.03.033</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adults adverse effects Animals antioxidants Biological and medical sciences blood serum brain caffeine Caffeine - toxicity drinking excretion Fluoride and caffeine Fluoride in urine Fluorides - toxicity kidneys Lipid peroxidation liver Male Male rats Medical sciences Nitric oxide Oxidative Stress Rats Rats, Wistar tap water Thiobarbituric Acid Reactive Substances Total antioxidant potential Toxicology urine Water Supply |
| title | Oxidative stress parameters in rats exposed to fluoride and caffeine |
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