Simulated microgravity alters growth and microcystin production in Microcystis aeruginosa (cyanophyta)
Recent researches indicated that microgravity can increase pathogenic bacteria virulence. We presumed that microgravity might affect the toxin production of toxic cyanobacteria too. Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (...
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| Veröffentlicht in: | Toxicon (Oxford) 2010-08, Vol.56 (1), p.1-7 |
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| creator | Xiao, Yuan Liu, Yongding Wang, Gaohong Hao, Zongjie An, Yanjun |
| description | Recent researches indicated that microgravity can increase pathogenic bacteria virulence. We presumed that microgravity might affect the toxin production of toxic cyanobacteria too.
Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (SMG) on the growth and toxin production of toxic cyanobacteria. SMG could inhibit the growth of
M. aeruginosa, which resulted in decreased cell number and lower specific growth rate after 20-day treatment.
M. aeruginosa sensed the reduced gravity very quickly and immediately up-regulated its microcystin (MC) synthesis and exudation in 2 days. Subsequently, the intracellular MC content fell back since the 8
th day and was stable around the initial level in the following days, suggesting a quick adaptation to the reduced gravity. SMG had negative effects on the photochemical system and the absorption of phosphorus in most time. However, the photosynthetic pigment concentrations and nitrogen absorption used to be transitorily stimulated upwards by SMG. It was assumed that SMG inhibited cell growth by interfering its photosynthesis and phosphorus uptake, while the enhanced MC production was related with pigment and nitrogen metabolisms. This study reveals that SMG is a novel environmental signal which inhibits growth and enhances MC production of
M. aeruginosa. |
| doi_str_mv | 10.1016/j.toxicon.2010.01.026 |
| format | Article |
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Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (SMG) on the growth and toxin production of toxic cyanobacteria. SMG could inhibit the growth of
M. aeruginosa, which resulted in decreased cell number and lower specific growth rate after 20-day treatment.
M. aeruginosa sensed the reduced gravity very quickly and immediately up-regulated its microcystin (MC) synthesis and exudation in 2 days. Subsequently, the intracellular MC content fell back since the 8
th day and was stable around the initial level in the following days, suggesting a quick adaptation to the reduced gravity. SMG had negative effects on the photochemical system and the absorption of phosphorus in most time. However, the photosynthetic pigment concentrations and nitrogen absorption used to be transitorily stimulated upwards by SMG. It was assumed that SMG inhibited cell growth by interfering its photosynthesis and phosphorus uptake, while the enhanced MC production was related with pigment and nitrogen metabolisms. This study reveals that SMG is a novel environmental signal which inhibits growth and enhances MC production of
M. aeruginosa.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/j.toxicon.2010.01.026</identifier><identifier>PMID: 20156472</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Absorption ; Adaptation, Physiological ; Animal poisons toxicology. Antivenoms ; Bacteria ; Bacterial Proteins - metabolism ; Bacterial Toxins - isolation & purification ; Bacterial Toxins - metabolism ; Bacteriology ; Biological and medical sciences ; Carotenoids - analysis ; Cell Proliferation ; Chlorophyll - analysis ; Cyanobacteria ; Fundamental and applied biological sciences. Psychology ; Gravitation ; Marine Toxins - isolation & purification ; Marine Toxins - metabolism ; Medical sciences ; Microbiology ; Microcystin ; Microcystins - isolation & purification ; Microcystins - metabolism ; Microcystis ; Microcystis - growth & development ; Microcystis - metabolism ; Microcystis - pathogenicity ; Microcystis aeruginosa ; Microgravity ; Nitrates - metabolism ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Phosphates - metabolism ; Phosphorus ; Photosystem II Protein Complex - metabolism ; Phycocyanin - analysis ; Secondary metabolism ; Simulated microgravity ; Time Factors ; Toxic ; Toxicology ; Toxins ; Up-Regulation ; Weightlessness Simulation</subject><ispartof>Toxicon (Oxford), 2010-08, Vol.56 (1), p.1-7</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-78525d3b2a175c344b44404b0fec13347458536fd83a15bbd413bd0fec95643c3</citedby><cites>FETCH-LOGICAL-c459t-78525d3b2a175c344b44404b0fec13347458536fd83a15bbd413bd0fec95643c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041010110000656$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22795711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20156472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Yuan</creatorcontrib><creatorcontrib>Liu, Yongding</creatorcontrib><creatorcontrib>Wang, Gaohong</creatorcontrib><creatorcontrib>Hao, Zongjie</creatorcontrib><creatorcontrib>An, Yanjun</creatorcontrib><title>Simulated microgravity alters growth and microcystin production in Microcystis aeruginosa (cyanophyta)</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Recent researches indicated that microgravity can increase pathogenic bacteria virulence. We presumed that microgravity might affect the toxin production of toxic cyanobacteria too.
Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (SMG) on the growth and toxin production of toxic cyanobacteria. SMG could inhibit the growth of
M. aeruginosa, which resulted in decreased cell number and lower specific growth rate after 20-day treatment.
M. aeruginosa sensed the reduced gravity very quickly and immediately up-regulated its microcystin (MC) synthesis and exudation in 2 days. Subsequently, the intracellular MC content fell back since the 8
th day and was stable around the initial level in the following days, suggesting a quick adaptation to the reduced gravity. SMG had negative effects on the photochemical system and the absorption of phosphorus in most time. However, the photosynthetic pigment concentrations and nitrogen absorption used to be transitorily stimulated upwards by SMG. It was assumed that SMG inhibited cell growth by interfering its photosynthesis and phosphorus uptake, while the enhanced MC production was related with pigment and nitrogen metabolisms. This study reveals that SMG is a novel environmental signal which inhibits growth and enhances MC production of
M. aeruginosa.</description><subject>Absorption</subject><subject>Adaptation, Physiological</subject><subject>Animal poisons toxicology. Antivenoms</subject><subject>Bacteria</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacterial Toxins - isolation & purification</subject><subject>Bacterial Toxins - metabolism</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - analysis</subject><subject>Cell Proliferation</subject><subject>Chlorophyll - analysis</subject><subject>Cyanobacteria</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gravitation</subject><subject>Marine Toxins - isolation & purification</subject><subject>Marine Toxins - metabolism</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Microcystin</subject><subject>Microcystins - isolation & purification</subject><subject>Microcystins - metabolism</subject><subject>Microcystis</subject><subject>Microcystis - growth & development</subject><subject>Microcystis - metabolism</subject><subject>Microcystis - pathogenicity</subject><subject>Microcystis aeruginosa</subject><subject>Microgravity</subject><subject>Nitrates - metabolism</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Phosphates - metabolism</subject><subject>Phosphorus</subject><subject>Photosystem II Protein Complex - metabolism</subject><subject>Phycocyanin - analysis</subject><subject>Secondary metabolism</subject><subject>Simulated microgravity</subject><subject>Time Factors</subject><subject>Toxic</subject><subject>Toxicology</subject><subject>Toxins</subject><subject>Up-Regulation</subject><subject>Weightlessness Simulation</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJ4ByQZRDlpnYzsepQlX5kIo4AGfLsZ2tV4m92E4h_75ebSg3OFn2-4znnXkJeYmwRcD63X6b_G-rvNtWkN8At1DVj8gG26YrKXJ4TDYADMus4hl5FuMeAGjb1U_JWS7hNWuqDRm-2WkeZTK6mKwKfhfknU1LIcdkQix2wf9Kt4V0q6yWmKwrDsHrWSXrXZFvXx6UWEgT5p11PsriQi3S-cPtkuTb5-TJIMdoXqznOfnx4fr71afy5uvHz1fvb0rFeJfKpuUV17SvJDZcUcZ6xhiwHgajkFLWMN5yWg-6pRJ532uGtNdHtcvzUEXPyZvTv9nhz9nEJCYblRlH6Yyfo2hqqABaZJm8-CeJdYPZTNVhRvkJzWPGGMwgDsFOMiwCQRzDEHuxhiGOYQhAkcPIda_WFnM_Gf1Q9Wf7GXi9AjIqOQ5BOmXjX65qOt7g0cDliTN5dXfWBBGVNU4ZbYNRSWhv_2PlHnaRq84</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Xiao, Yuan</creator><creator>Liu, Yongding</creator><creator>Wang, Gaohong</creator><creator>Hao, Zongjie</creator><creator>An, Yanjun</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20100801</creationdate><title>Simulated microgravity alters growth and microcystin production in Microcystis aeruginosa (cyanophyta)</title><author>Xiao, Yuan ; Liu, Yongding ; Wang, Gaohong ; Hao, Zongjie ; An, Yanjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-78525d3b2a175c344b44404b0fec13347458536fd83a15bbd413bd0fec95643c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorption</topic><topic>Adaptation, Physiological</topic><topic>Animal poisons toxicology. Antivenoms</topic><topic>Bacteria</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacterial Toxins - isolation & purification</topic><topic>Bacterial Toxins - metabolism</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - analysis</topic><topic>Cell Proliferation</topic><topic>Chlorophyll - analysis</topic><topic>Cyanobacteria</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gravitation</topic><topic>Marine Toxins - isolation & purification</topic><topic>Marine Toxins - metabolism</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Microcystin</topic><topic>Microcystins - isolation & purification</topic><topic>Microcystins - metabolism</topic><topic>Microcystis</topic><topic>Microcystis - growth & development</topic><topic>Microcystis - metabolism</topic><topic>Microcystis - pathogenicity</topic><topic>Microcystis aeruginosa</topic><topic>Microgravity</topic><topic>Nitrates - metabolism</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Phosphates - metabolism</topic><topic>Phosphorus</topic><topic>Photosystem II Protein Complex - metabolism</topic><topic>Phycocyanin - analysis</topic><topic>Secondary metabolism</topic><topic>Simulated microgravity</topic><topic>Time Factors</topic><topic>Toxic</topic><topic>Toxicology</topic><topic>Toxins</topic><topic>Up-Regulation</topic><topic>Weightlessness Simulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Yuan</creatorcontrib><creatorcontrib>Liu, Yongding</creatorcontrib><creatorcontrib>Wang, Gaohong</creatorcontrib><creatorcontrib>Hao, Zongjie</creatorcontrib><creatorcontrib>An, Yanjun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Yuan</au><au>Liu, Yongding</au><au>Wang, Gaohong</au><au>Hao, Zongjie</au><au>An, Yanjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simulated microgravity alters growth and microcystin production in Microcystis aeruginosa (cyanophyta)</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>56</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Recent researches indicated that microgravity can increase pathogenic bacteria virulence. We presumed that microgravity might affect the toxin production of toxic cyanobacteria too.
Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (SMG) on the growth and toxin production of toxic cyanobacteria. SMG could inhibit the growth of
M. aeruginosa, which resulted in decreased cell number and lower specific growth rate after 20-day treatment.
M. aeruginosa sensed the reduced gravity very quickly and immediately up-regulated its microcystin (MC) synthesis and exudation in 2 days. Subsequently, the intracellular MC content fell back since the 8
th day and was stable around the initial level in the following days, suggesting a quick adaptation to the reduced gravity. SMG had negative effects on the photochemical system and the absorption of phosphorus in most time. However, the photosynthetic pigment concentrations and nitrogen absorption used to be transitorily stimulated upwards by SMG. It was assumed that SMG inhibited cell growth by interfering its photosynthesis and phosphorus uptake, while the enhanced MC production was related with pigment and nitrogen metabolisms. This study reveals that SMG is a novel environmental signal which inhibits growth and enhances MC production of
M. aeruginosa.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20156472</pmid><doi>10.1016/j.toxicon.2010.01.026</doi><tpages>7</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 2010-08, Vol.56 (1), p.1-7 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Absorption Adaptation, Physiological Animal poisons toxicology. Antivenoms Bacteria Bacterial Proteins - metabolism Bacterial Toxins - isolation & purification Bacterial Toxins - metabolism Bacteriology Biological and medical sciences Carotenoids - analysis Cell Proliferation Chlorophyll - analysis Cyanobacteria Fundamental and applied biological sciences. Psychology Gravitation Marine Toxins - isolation & purification Marine Toxins - metabolism Medical sciences Microbiology Microcystin Microcystins - isolation & purification Microcystins - metabolism Microcystis Microcystis - growth & development Microcystis - metabolism Microcystis - pathogenicity Microcystis aeruginosa Microgravity Nitrates - metabolism Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Phosphates - metabolism Phosphorus Photosystem II Protein Complex - metabolism Phycocyanin - analysis Secondary metabolism Simulated microgravity Time Factors Toxic Toxicology Toxins Up-Regulation Weightlessness Simulation |
| title | Simulated microgravity alters growth and microcystin production in Microcystis aeruginosa (cyanophyta) |
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