Protective role of propolis against reproductive toxicity of triphenyltin in male rabbits
Triphenyltin (TPT) is known to cause endocrine disruption, reproductive toxicity and a decrease in testosterone production. It is involved in the production of reactive oxygen species. Propolis has been reported to be an important antioxidant. Therefore, the present study aimed to elucidate the poss...
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| Veröffentlicht in: | Food and chemical toxicology 2010-07, Vol.48 (7), p.1846-1852 |
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| creator | Yousef, Mokhtar I. Kamel, Kamel I. Hassan, Mervat S. El-Morsy, Ahmed M.A. |
| description | Triphenyltin (TPT) is known to cause endocrine disruption, reproductive toxicity and a decrease in testosterone production. It is involved in the production of reactive oxygen species. Propolis has been reported to be an important antioxidant. Therefore, the present study aimed to elucidate the possible protective effects of propolis in alleviating the toxicity of triphenyltin chloride (TPTCl) on reproductive performance, testosterone levels, lipid peroxidation and enzyme activities in seminal plasma of male New Zealand white rabbits. Animals were orally administered the doses of propolis, TPTCl and propolis plus TPTCl every day for 12weeks. Results showed that semen quality was deteriorated following treatment with TPTCl. Also, testosterone levels, body weight (BW), relative weights of testes (RWT) and epididymis (RWE) were decreased. Thiobarbituric acid-reactive substances and lactate dehydrogenase were increased, while glutathione S-transferase, transaminases and phosphatases were decreased in seminal plasma of rabbits treated with TPTCl compared to control. Propolis alone significantly increased testosterone levels, BW, RTW, REW, semen characteristics and seminal plasma enzymes, and decreased the levels of free radicals and lactate dehydrogenase. Furthermore, the presence of propolis with TPTCl alleviates its toxic effects. From the present study, it can be concluded propolis can be effective in the protection of TPTCl-induced reproductive toxicity. |
| doi_str_mv | 10.1016/j.fct.2010.04.018 |
| format | Article |
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It is involved in the production of reactive oxygen species. Propolis has been reported to be an important antioxidant. Therefore, the present study aimed to elucidate the possible protective effects of propolis in alleviating the toxicity of triphenyltin chloride (TPTCl) on reproductive performance, testosterone levels, lipid peroxidation and enzyme activities in seminal plasma of male New Zealand white rabbits. Animals were orally administered the doses of propolis, TPTCl and propolis plus TPTCl every day for 12weeks. Results showed that semen quality was deteriorated following treatment with TPTCl. Also, testosterone levels, body weight (BW), relative weights of testes (RWT) and epididymis (RWE) were decreased. Thiobarbituric acid-reactive substances and lactate dehydrogenase were increased, while glutathione S-transferase, transaminases and phosphatases were decreased in seminal plasma of rabbits treated with TPTCl compared to control. Propolis alone significantly increased testosterone levels, BW, RTW, REW, semen characteristics and seminal plasma enzymes, and decreased the levels of free radicals and lactate dehydrogenase. Furthermore, the presence of propolis with TPTCl alleviates its toxic effects. From the present study, it can be concluded propolis can be effective in the protection of TPTCl-induced reproductive toxicity.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2010.04.018</identifier><identifier>PMID: 20399825</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; antioxidants ; Antioxidants - metabolism ; Biological and medical sciences ; body weight ; Body Weight - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; Eating - drug effects ; enzyme activity ; epididymis ; Epididymis - drug effects ; Free radicals ; glutathione transferase ; Infertility, Male - chemically induced ; Infertility, Male - prevention & control ; lactate dehydrogenase ; lipid peroxidation ; Male ; Medical sciences ; Metals and various inorganic compounds ; oral administration ; Organ Size - drug effects ; Organotin Compounds - antagonists & inhibitors ; Organotin Compounds - toxicity ; Propolis ; Propolis - pharmacology ; protective effect ; Rabbits ; Reaction Time - drug effects ; reactive oxygen species ; reproductive performance ; Reproductive toxicity ; reproductive toxicology ; Semen - cytology ; Semen - drug effects ; Semen - enzymology ; seminal plasma ; Seminal plasma biochemical parameters ; Sperm Count ; testes ; Testicular Diseases - chemically induced ; Testicular Diseases - physiopathology ; Testicular Diseases - prevention & control ; Testis - drug effects ; testosterone ; Testosterone - blood ; thiobarbituric acid-reactive substances ; toxicity ; Toxicology ; transaminases ; Triphenyltin chloride</subject><ispartof>Food and chemical toxicology, 2010-07, Vol.48 (7), p.1846-1852</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2010 Elsevier Ltd. 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It is involved in the production of reactive oxygen species. Propolis has been reported to be an important antioxidant. Therefore, the present study aimed to elucidate the possible protective effects of propolis in alleviating the toxicity of triphenyltin chloride (TPTCl) on reproductive performance, testosterone levels, lipid peroxidation and enzyme activities in seminal plasma of male New Zealand white rabbits. Animals were orally administered the doses of propolis, TPTCl and propolis plus TPTCl every day for 12weeks. Results showed that semen quality was deteriorated following treatment with TPTCl. Also, testosterone levels, body weight (BW), relative weights of testes (RWT) and epididymis (RWE) were decreased. Thiobarbituric acid-reactive substances and lactate dehydrogenase were increased, while glutathione S-transferase, transaminases and phosphatases were decreased in seminal plasma of rabbits treated with TPTCl compared to control. Propolis alone significantly increased testosterone levels, BW, RTW, REW, semen characteristics and seminal plasma enzymes, and decreased the levels of free radicals and lactate dehydrogenase. Furthermore, the presence of propolis with TPTCl alleviates its toxic effects. From the present study, it can be concluded propolis can be effective in the protection of TPTCl-induced reproductive toxicity.</description><subject>Animals</subject><subject>antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>body weight</subject><subject>Body Weight - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Eating - drug effects</subject><subject>enzyme activity</subject><subject>epididymis</subject><subject>Epididymis - drug effects</subject><subject>Free radicals</subject><subject>glutathione transferase</subject><subject>Infertility, Male - chemically induced</subject><subject>Infertility, Male - prevention & control</subject><subject>lactate dehydrogenase</subject><subject>lipid peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>oral administration</subject><subject>Organ Size - drug effects</subject><subject>Organotin Compounds - antagonists & inhibitors</subject><subject>Organotin Compounds - toxicity</subject><subject>Propolis</subject><subject>Propolis - pharmacology</subject><subject>protective effect</subject><subject>Rabbits</subject><subject>Reaction Time - drug effects</subject><subject>reactive oxygen species</subject><subject>reproductive performance</subject><subject>Reproductive toxicity</subject><subject>reproductive toxicology</subject><subject>Semen - cytology</subject><subject>Semen - drug effects</subject><subject>Semen - enzymology</subject><subject>seminal plasma</subject><subject>Seminal plasma biochemical parameters</subject><subject>Sperm Count</subject><subject>testes</subject><subject>Testicular Diseases - chemically induced</subject><subject>Testicular Diseases - physiopathology</subject><subject>Testicular Diseases - prevention & control</subject><subject>Testis - drug effects</subject><subject>testosterone</subject><subject>Testosterone - blood</subject><subject>thiobarbituric acid-reactive substances</subject><subject>toxicity</subject><subject>Toxicology</subject><subject>transaminases</subject><subject>Triphenyltin chloride</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFDEYgIModq3-AC86F_E023xNPvAkxS8oWNAePIVM8qZmmZ2sSbZ0_71ZZtVbhYSQ8LxfTxB6SfCaYCIuNuvg6pridsd8jYl6hFZESdYLNpDHaIWpVL3QZDhDz0rZYIwlkeIpOqOYaa3osEI_rnOq4Gq8gy6nCboUul1OuzTF0tlbG-dSuwztye8Xqqb76GI9HMma4-4nzIepxrlra2tbhmzHMdbyHD0Jdirw4nSeo5uPH75ffu6vvn76cvn-qnecqdoPTgkxgrXecSdFUEpL4EEGRrXQygbuCR_VaAMlcvAiBKz4KJ2n3jniNTtHb5e8rcdfeyjVbGNxME12hrQvRgpM2-SK_p_kSjONNW8kWUiXUykZgtnluLX5YAg2R_VmY5p6c1RvMDdNfYt5dcq-H7fg_0b8cd2ANyfAFmenkO3sYvnHUa3YIEXjXi9csMnY29yYm2-t0oDbZpwcB3m3ENC83kXIprgIswMfc_tL41N8oNHfRbKsBA</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Yousef, Mokhtar I.</creator><creator>Kamel, Kamel I.</creator><creator>Hassan, Mervat S.</creator><creator>El-Morsy, Ahmed M.A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20100701</creationdate><title>Protective role of propolis against reproductive toxicity of triphenyltin in male rabbits</title><author>Yousef, Mokhtar I. ; Kamel, Kamel I. ; Hassan, Mervat S. ; El-Morsy, Ahmed M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-5c866beaadc4c76f8897e4f7f329698af4d14b8baf2175d6ff084b7cd2dcc1d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>body weight</topic><topic>Body Weight - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Eating - drug effects</topic><topic>enzyme activity</topic><topic>epididymis</topic><topic>Epididymis - drug effects</topic><topic>Free radicals</topic><topic>glutathione transferase</topic><topic>Infertility, Male - chemically induced</topic><topic>Infertility, Male - prevention & control</topic><topic>lactate dehydrogenase</topic><topic>lipid peroxidation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>oral administration</topic><topic>Organ Size - drug effects</topic><topic>Organotin Compounds - antagonists & inhibitors</topic><topic>Organotin Compounds - toxicity</topic><topic>Propolis</topic><topic>Propolis - pharmacology</topic><topic>protective effect</topic><topic>Rabbits</topic><topic>Reaction Time - drug effects</topic><topic>reactive oxygen species</topic><topic>reproductive performance</topic><topic>Reproductive toxicity</topic><topic>reproductive toxicology</topic><topic>Semen - cytology</topic><topic>Semen - drug effects</topic><topic>Semen - enzymology</topic><topic>seminal plasma</topic><topic>Seminal plasma biochemical parameters</topic><topic>Sperm Count</topic><topic>testes</topic><topic>Testicular Diseases - chemically induced</topic><topic>Testicular Diseases - physiopathology</topic><topic>Testicular Diseases - prevention & control</topic><topic>Testis - drug effects</topic><topic>testosterone</topic><topic>Testosterone - blood</topic><topic>thiobarbituric acid-reactive substances</topic><topic>toxicity</topic><topic>Toxicology</topic><topic>transaminases</topic><topic>Triphenyltin chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yousef, Mokhtar I.</creatorcontrib><creatorcontrib>Kamel, Kamel I.</creatorcontrib><creatorcontrib>Hassan, Mervat S.</creatorcontrib><creatorcontrib>El-Morsy, Ahmed M.A.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yousef, Mokhtar I.</au><au>Kamel, Kamel I.</au><au>Hassan, Mervat S.</au><au>El-Morsy, Ahmed M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective role of propolis against reproductive toxicity of triphenyltin in male rabbits</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>48</volume><issue>7</issue><spage>1846</spage><epage>1852</epage><pages>1846-1852</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Triphenyltin (TPT) is known to cause endocrine disruption, reproductive toxicity and a decrease in testosterone production. It is involved in the production of reactive oxygen species. Propolis has been reported to be an important antioxidant. Therefore, the present study aimed to elucidate the possible protective effects of propolis in alleviating the toxicity of triphenyltin chloride (TPTCl) on reproductive performance, testosterone levels, lipid peroxidation and enzyme activities in seminal plasma of male New Zealand white rabbits. Animals were orally administered the doses of propolis, TPTCl and propolis plus TPTCl every day for 12weeks. Results showed that semen quality was deteriorated following treatment with TPTCl. Also, testosterone levels, body weight (BW), relative weights of testes (RWT) and epididymis (RWE) were decreased. Thiobarbituric acid-reactive substances and lactate dehydrogenase were increased, while glutathione S-transferase, transaminases and phosphatases were decreased in seminal plasma of rabbits treated with TPTCl compared to control. Propolis alone significantly increased testosterone levels, BW, RTW, REW, semen characteristics and seminal plasma enzymes, and decreased the levels of free radicals and lactate dehydrogenase. Furthermore, the presence of propolis with TPTCl alleviates its toxic effects. From the present study, it can be concluded propolis can be effective in the protection of TPTCl-induced reproductive toxicity.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>20399825</pmid><doi>10.1016/j.fct.2010.04.018</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals antioxidants Antioxidants - metabolism Biological and medical sciences body weight Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Eating - drug effects enzyme activity epididymis Epididymis - drug effects Free radicals glutathione transferase Infertility, Male - chemically induced Infertility, Male - prevention & control lactate dehydrogenase lipid peroxidation Male Medical sciences Metals and various inorganic compounds oral administration Organ Size - drug effects Organotin Compounds - antagonists & inhibitors Organotin Compounds - toxicity Propolis Propolis - pharmacology protective effect Rabbits Reaction Time - drug effects reactive oxygen species reproductive performance Reproductive toxicity reproductive toxicology Semen - cytology Semen - drug effects Semen - enzymology seminal plasma Seminal plasma biochemical parameters Sperm Count testes Testicular Diseases - chemically induced Testicular Diseases - physiopathology Testicular Diseases - prevention & control Testis - drug effects testosterone Testosterone - blood thiobarbituric acid-reactive substances toxicity Toxicology transaminases Triphenyltin chloride |
| title | Protective role of propolis against reproductive toxicity of triphenyltin in male rabbits |
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