Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4 )-induced liver injury in mice

Abstract The anti-inflammatory and antioxidant effects of epigallocatechin-3-gallate (EGCG) are considered important forces in attenuate liver injury and fibrosis. The aim of the study was to investigate the effect of EGCG on the expression of fibrogenic factors and whether EGCG attenuates the sever...

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Veröffentlicht in:	Toxicology (Amsterdam) 2010-06, Vol.273 (1), p.45-52
Hauptverfasser:	Tipoe, George L, Leung, Tung Ming, Liong, Emily C, Lau, Thomas Yue Huen, Fung, Man Lung, Nanji, Amin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Carbon Tetrachloride Carbon tetrachloride (CCl 4) Catechin - analogs & derivatives Catechin - therapeutic use Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Collagen Type I - metabolism Cyclooxygenase 2 Inhibitors - metabolism Emergency Epigallocatechin-3-gallate (EGCG) Gastroenterology. Liver. Pancreas. Abdomen Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver fibrosis Liver inflammation Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Matrix Metalloproteinases - metabolism Medical sciences Mice Mice, Inbred C57BL Nitric Oxide Synthase Type II - metabolism Other diseases. Semiology Oxidative stress Oxidative Stress - drug effects Tissue Inhibitor of Metalloproteinases - metabolism Toxicology Transforming Growth Factor beta1 - metabolism Tumor Necrosis Factor-alpha - metabolism Tyrosine - analogs & derivatives Tyrosine - metabolism
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