Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria

Methotrexate (MTX) is a folic acid antagonist widely used as a cytotoxic chemotherapeutic agent for leukemia and other malignancies. The purpose of this study was to investigate the damage caused by MTX on liver mitochondria and its protection by using antioxidant properties of lipoic acid. MTX subs...

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Veröffentlicht in:	Food and chemical toxicology 2010-07, Vol.48 (7), p.1973-1979
Hauptverfasser:	Tabassum, Heena, Parvez, Suhel, Pasha, Syed Tazeen, Banerjee, Basu Dev, Raisuddin, Sheikh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists antioxidant activity Antioxidants Biological and medical sciences Body Weight - drug effects cytotoxicity DNA - metabolism drug therapy Focusing folic acid Folic Acid Antagonists - toxicity Free Radicals - metabolism glutathione Glutathione - metabolism Glutathione Peroxidase - metabolism In Vitro Techniques leukemia Lipid Metabolism - drug effects Lipid peroxidation Lipoic acid Liver Medical sciences Methotrexate Methotrexate - antagonists & inhibitors Methotrexate - toxicity Mice Mitochondria Mitochondria, Liver - drug effects Oxidation-Reduction Oxidative stress Oxidative Stress - drug effects Polycarbonates pretreatment protective effect Protein Carbonylation - drug effects Radicals Stresses Sulfhydryl Compounds - metabolism superoxide anion Superoxide Dismutase - metabolism Superoxides - metabolism Thiobarbituric Acid Reactive Substances - metabolism Thioctic Acid - pharmacology thiols Toxicity Toxicology
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