Effect of growth hormone on rat liver N-acetyl- l-glutamate

Effect of growth hormone on rat liver N-acetyl- l-glutamate

Earlier studies have revealed, upon hypophysectomy, a specific increase in mitochondrial urea cycle enzymes, namely carbamyl phosphate synthetase and ornithine transcarbamylase. Administration of growth hormone to hypophysectomized rats brought these enzyme activities back to normal. Since growth ho...

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Veröffentlicht in:Archives of biochemistry and biophysics 1985-03, Vol.237 (2), p.430-432
Hauptverfasser: Palekar, Anil G., Angadi, Channabasappa V.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - metabolism
Enzyme Activation - drug effects
Fundamental and applied biological sciences. Psychology
Glutamates - metabolism
Growth Hormone - pharmacology
Hypophysectomy
Liver - enzymology
Liver - metabolism
Liver. Bile. Biliary tracts
Male
Rats
Rats, Inbred Strains
Vertebrates: digestive system
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container_title Archives of biochemistry and biophysics
container_volume 237
creator Palekar, Anil G.
Angadi, Channabasappa V.
description Earlier studies have revealed, upon hypophysectomy, a specific increase in mitochondrial urea cycle enzymes, namely carbamyl phosphate synthetase and ornithine transcarbamylase. Administration of growth hormone to hypophysectomized rats brought these enzyme activities back to normal. Since growth hormone plays a role in the formation of citrulline and ultimately urea, in the present study its effect on the levels of N-acetyl- l-glutamate, an allosteric activator of carbamyl phosphate synthetase has been investigated. A significant increase in N-acetyl- l-glutamate concentration in rat liver on hypophysectomy and its reversal back to normal levels on growth hormone administration was reported. These results suggest that the lack of growth hormone tends to amplify urea production by the liver.
doi_str_mv 10.1016/0003-9861(85)90296-6
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subjects Animals
Biological and medical sciences
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - metabolism
Enzyme Activation - drug effects
Fundamental and applied biological sciences. Psychology
Glutamates - metabolism
Growth Hormone - pharmacology
Hypophysectomy
Liver - enzymology
Liver - metabolism
Liver. Bile. Biliary tracts
Male
Rats
Rats, Inbred Strains
Vertebrates: digestive system
title Effect of growth hormone on rat liver N-acetyl- l-glutamate
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