Fibulin‐3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity

Nasopharyngeal carcinoma (NPC) is known for its highly metastatic character. Recent advances in diagnosis and treatment have not improved the high mortality rate that is attributable to early metastasis. Although several biomarkers correlate with metastasis and prognosis, the molecular mechanisms of...

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Veröffentlicht in:	The Journal of pathology 2010-12, Vol.222 (4), p.367-379
Hauptverfasser:	Hwang, Chung‐Feng, Chien, Chih‐Yen, Huang, Shun‐Cheng, Yin, Yu‐Fang, Huang, Chao‐Cheng, Fang, Fu‐Min, Tsai, Hsin‐Ting, Su, Li‐Jen, Chen, Chang‐Han
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Biological and medical sciences biomarkers Biomarkers, Tumor - metabolism Cell migration Cell Movement - physiology Disease Progression DNA Methylation DNA, Neoplasm - genetics Down-Regulation Extracellular Matrix Proteins - metabolism Extracellular Matrix Proteins - physiology Female fibulin-3 Gene Knockdown Techniques Humans invasion Investigative techniques, diagnostic techniques (general aspects) Lymph Male Medical sciences Metastases Middle Aged migration Molecular modelling Mortality Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neoplasm Invasiveness Neoplasm Proteins - metabolism Neoplasm Staging Otorhinolaryngology. Stomatology p-AKT Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction - methods Prognosis Promoter Regions, Genetic Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics siRNA Survival Analysis Tumor Cells, Cultured Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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