USE OF BASE DEFICIT TO COMPARE RESUSCITATION WITH LACTATED RINGERʼS SOLUTION, HAEMACCEL, WHOLE BLOOD, AND DIASPIRIN CROSS-LINKED HEMOGLOBIN FOLLOWING HEMORRHAGE IN RATS
Base deficit (BD) has been shown to be a sensitive measure of the degree and duration of inadequate perfusion. We developed a rat model of hemorrhagic shock based on achieving a fixed BD of 13 ± 1 mmol/L before resuscitation. Using this model, we compared the efficacy of resuscitation with lactated...
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| Veröffentlicht in: | The journal of trauma 1993-10, Vol.35 (4), p.619-636 |
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| creator | Schultz, Scot C. Hamilton, Ian N. Malcolm, Diana S. |
| description | Base deficit (BD) has been shown to be a sensitive measure of the degree and duration of inadequate perfusion. We developed a rat model of hemorrhagic shock based on achieving a fixed BD of 13 ± 1 mmol/L before resuscitation. Using this model, we compared the efficacy of resuscitation with lactated Ringerʼs solution (LR), Haemaccel (a colloid), and whole blood with that of diaspirin cross-linked hemoglobin (DCLHb, Baxter Healthcare Corp.) by evaluating improvements in BD and restoration of base excess (BE, positive correlate of BD) for 60 minutes following resuscitation. The DCLHb was superior to LR and Haemaccel in restoring and maintaining BE following resuscitation, and was able to restore BE as rapidly as whole blood at half the volume. At 60 minutes, DCLHb at twice the shed blood volume maintained BE at higher (more positive) values compared with all other treatment groups. We conclude that DCLHb is at least as effective as whole blood and superior to LR and Haemaccel in restoring BE within the first 60 minutes following resuscitation in this hemorrhagic shock model. |
| doi_str_mv | 10.1097/00005373-199310000-00019 |
| format | Article |
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We developed a rat model of hemorrhagic shock based on achieving a fixed BD of 13 ± 1 mmol/L before resuscitation. Using this model, we compared the efficacy of resuscitation with lactated Ringerʼs solution (LR), Haemaccel (a colloid), and whole blood with that of diaspirin cross-linked hemoglobin (DCLHb, Baxter Healthcare Corp.) by evaluating improvements in BD and restoration of base excess (BE, positive correlate of BD) for 60 minutes following resuscitation. The DCLHb was superior to LR and Haemaccel in restoring and maintaining BE following resuscitation, and was able to restore BE as rapidly as whole blood at half the volume. At 60 minutes, DCLHb at twice the shed blood volume maintained BE at higher (more positive) values compared with all other treatment groups. We conclude that DCLHb is at least as effective as whole blood and superior to LR and Haemaccel in restoring BE within the first 60 minutes following resuscitation in this hemorrhagic shock model.</description><identifier>ISSN: 0022-5282</identifier><identifier>EISSN: 1529-8809</identifier><identifier>DOI: 10.1097/00005373-199310000-00019</identifier><identifier>PMID: 8411288</identifier><language>eng</language><publisher>United States: Williams & Wilkins</publisher><subject>Acid-Base Equilibrium - physiology ; Animals ; Aspirin - analogs & derivatives ; Aspirin - therapeutic use ; Disease Models, Animal ; Hemoglobins - therapeutic use ; Isotonic Solutions - therapeutic use ; Male ; Polygeline - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Resuscitation - methods ; Ringer's Lactate ; Shock, Hemorrhagic - physiopathology ; Shock, Hemorrhagic - therapy</subject><ispartof>The journal of trauma, 1993-10, Vol.35 (4), p.619-636</ispartof><rights>Williams & Wilkins 1993. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3559-4ff720c1490845bd7e15f317c9562f5fa28eb50286881d69db4a6733eca483f23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8411288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schultz, Scot C.</creatorcontrib><creatorcontrib>Hamilton, Ian N.</creatorcontrib><creatorcontrib>Malcolm, Diana S.</creatorcontrib><title>USE OF BASE DEFICIT TO COMPARE RESUSCITATION WITH LACTATED RINGERʼS SOLUTION, HAEMACCEL, WHOLE BLOOD, AND DIASPIRIN CROSS-LINKED HEMOGLOBIN FOLLOWING HEMORRHAGE IN RATS</title><title>The journal of trauma</title><addtitle>J Trauma</addtitle><description>Base deficit (BD) has been shown to be a sensitive measure of the degree and duration of inadequate perfusion. We developed a rat model of hemorrhagic shock based on achieving a fixed BD of 13 ± 1 mmol/L before resuscitation. Using this model, we compared the efficacy of resuscitation with lactated Ringerʼs solution (LR), Haemaccel (a colloid), and whole blood with that of diaspirin cross-linked hemoglobin (DCLHb, Baxter Healthcare Corp.) by evaluating improvements in BD and restoration of base excess (BE, positive correlate of BD) for 60 minutes following resuscitation. The DCLHb was superior to LR and Haemaccel in restoring and maintaining BE following resuscitation, and was able to restore BE as rapidly as whole blood at half the volume. At 60 minutes, DCLHb at twice the shed blood volume maintained BE at higher (more positive) values compared with all other treatment groups. We conclude that DCLHb is at least as effective as whole blood and superior to LR and Haemaccel in restoring BE within the first 60 minutes following resuscitation in this hemorrhagic shock model.</description><subject>Acid-Base Equilibrium - physiology</subject><subject>Animals</subject><subject>Aspirin - analogs & derivatives</subject><subject>Aspirin - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Hemoglobins - therapeutic use</subject><subject>Isotonic Solutions - therapeutic use</subject><subject>Male</subject><subject>Polygeline - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Resuscitation - methods</subject><subject>Ringer's Lactate</subject><subject>Shock, Hemorrhagic - physiopathology</subject><subject>Shock, Hemorrhagic - therapy</subject><issn>0022-5282</issn><issn>1529-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1u2zAQhYmiReqmPUIBrrqyGv6IErmkJdoSSpuBJMNLQpYpJK1cJ5KNoEfqHXKCnCp07GQXAsRg3rw3s_gAgBj9xEjEV8g_RmMaYCEoPnaB_1h8ACPMiAg4R-IjGCFESMAIJ5_Bl2H47S1hSPkFuOAhxoTzEfi_LBU0UziRvqZqmid5BSsDEzO_loWChSqXpddklZsFXOVVBrVMfKtSWOSLmSqeHktYGr08GsYwk2ouk0TpMVxlRis40cakYygXKUxzWV7nPgWTwpRloPPFL78mU3Mz02bi9anR2qz82hexKDI5U9DrhazKr-BTW3eD-3aul2A5VVWSBdrM8kTqoKGMiSBs25igBocC8ZCtN7HDrKU4bgSLSMvamnC3ZojwiHO8icRmHdZRTKlr6pDTltBL8OO0967f3R_csLfb26FxXVf_dbvDYOMIYSrQ0chPxqbfDUPvWnvX327r_p_FyB4p2VdK9o2SfaHko9_PNw7rrdu8Bc9Y_Dw8zR923d71w5_u8OB6e-Pqbn9j34NPnwGhIY8s</recordid><startdate>199310</startdate><enddate>199310</enddate><creator>Schultz, Scot C.</creator><creator>Hamilton, Ian N.</creator><creator>Malcolm, Diana S.</creator><general>Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199310</creationdate><title>USE OF BASE DEFICIT TO COMPARE RESUSCITATION WITH LACTATED RINGERʼS SOLUTION, HAEMACCEL, WHOLE BLOOD, AND DIASPIRIN CROSS-LINKED HEMOGLOBIN FOLLOWING HEMORRHAGE IN RATS</title><author>Schultz, Scot C. ; Hamilton, Ian N. ; Malcolm, Diana S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3559-4ff720c1490845bd7e15f317c9562f5fa28eb50286881d69db4a6733eca483f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acid-Base Equilibrium - physiology</topic><topic>Animals</topic><topic>Aspirin - analogs & derivatives</topic><topic>Aspirin - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Hemoglobins - therapeutic use</topic><topic>Isotonic Solutions - therapeutic use</topic><topic>Male</topic><topic>Polygeline - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Resuscitation - methods</topic><topic>Ringer's Lactate</topic><topic>Shock, Hemorrhagic - physiopathology</topic><topic>Shock, Hemorrhagic - therapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Schultz, Scot C.</creatorcontrib><creatorcontrib>Hamilton, Ian N.</creatorcontrib><creatorcontrib>Malcolm, Diana S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of trauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schultz, Scot C.</au><au>Hamilton, Ian N.</au><au>Malcolm, Diana S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>USE OF BASE DEFICIT TO COMPARE RESUSCITATION WITH LACTATED RINGERʼS SOLUTION, HAEMACCEL, WHOLE BLOOD, AND DIASPIRIN CROSS-LINKED HEMOGLOBIN FOLLOWING HEMORRHAGE IN RATS</atitle><jtitle>The journal of trauma</jtitle><addtitle>J Trauma</addtitle><date>1993-10</date><risdate>1993</risdate><volume>35</volume><issue>4</issue><spage>619</spage><epage>636</epage><pages>619-636</pages><issn>0022-5282</issn><eissn>1529-8809</eissn><abstract>Base deficit (BD) has been shown to be a sensitive measure of the degree and duration of inadequate perfusion. We developed a rat model of hemorrhagic shock based on achieving a fixed BD of 13 ± 1 mmol/L before resuscitation. Using this model, we compared the efficacy of resuscitation with lactated Ringerʼs solution (LR), Haemaccel (a colloid), and whole blood with that of diaspirin cross-linked hemoglobin (DCLHb, Baxter Healthcare Corp.) by evaluating improvements in BD and restoration of base excess (BE, positive correlate of BD) for 60 minutes following resuscitation. The DCLHb was superior to LR and Haemaccel in restoring and maintaining BE following resuscitation, and was able to restore BE as rapidly as whole blood at half the volume. At 60 minutes, DCLHb at twice the shed blood volume maintained BE at higher (more positive) values compared with all other treatment groups. We conclude that DCLHb is at least as effective as whole blood and superior to LR and Haemaccel in restoring BE within the first 60 minutes following resuscitation in this hemorrhagic shock model.</abstract><cop>United States</cop><pub>Williams & Wilkins</pub><pmid>8411288</pmid><doi>10.1097/00005373-199310000-00019</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5282 |
| ispartof | The journal of trauma, 1993-10, Vol.35 (4), p.619-636 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acid-Base Equilibrium - physiology Animals Aspirin - analogs & derivatives Aspirin - therapeutic use Disease Models, Animal Hemoglobins - therapeutic use Isotonic Solutions - therapeutic use Male Polygeline - therapeutic use Rats Rats, Sprague-Dawley Resuscitation - methods Ringer's Lactate Shock, Hemorrhagic - physiopathology Shock, Hemorrhagic - therapy |
| title | USE OF BASE DEFICIT TO COMPARE RESUSCITATION WITH LACTATED RINGERʼS SOLUTION, HAEMACCEL, WHOLE BLOOD, AND DIASPIRIN CROSS-LINKED HEMOGLOBIN FOLLOWING HEMORRHAGE IN RATS |
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