Tobacco use and nasopharyngeal carcinoma in a cohort of us veterans
The risk of nasopharyngeal carcinoma (NPC), a relatively rare neoplasm in the United States, was examined in relation to tobacco use in a cohort of nearly 250,000 US veterans whose mortality experience was followed for 26 years. A total of 48 NPC deaths were identified during the follow‐up period. C...
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| Veröffentlicht in: | International journal of cancer 1993-10, Vol.55 (4), p.538-540 |
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| container_title | International journal of cancer |
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| creator | Chow, Wong‐Ho McLaughlin, Joseph K. Hrubec, Zdenek Nam, Jun‐Mo Blot, William J. |
| description | The risk of nasopharyngeal carcinoma (NPC), a relatively rare neoplasm in the United States, was examined in relation to tobacco use in a cohort of nearly 250,000 US veterans whose mortality experience was followed for 26 years. A total of 48 NPC deaths were identified during the follow‐up period. Current smokers had a nearly 4‐fold increase in risk of NPC compared with non‐users of any tobacco, with risk increasing to 6.4 among those smoking more than 2 packs daily. After adjustment for age and number of cigarettes smoked, risks were inversely associated with age at starting to smoke, with the highest risk observed among those who started smoking before age 15, although no clear trend associated with duration of smoking was observed. Former cigarette smokers had a small excess risk of NPC, but no association was detected for cigar/pipe users. This study adds strong evidence to the increasing literature linking cigarette smoking to NPC. |
| doi_str_mv | 10.1002/ijc.2910550403 |
| format | Article |
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A total of 48 NPC deaths were identified during the follow‐up period. Current smokers had a nearly 4‐fold increase in risk of NPC compared with non‐users of any tobacco, with risk increasing to 6.4 among those smoking more than 2 packs daily. After adjustment for age and number of cigarettes smoked, risks were inversely associated with age at starting to smoke, with the highest risk observed among those who started smoking before age 15, although no clear trend associated with duration of smoking was observed. Former cigarette smokers had a small excess risk of NPC, but no association was detected for cigar/pipe users. This study adds strong evidence to the increasing literature linking cigarette smoking to NPC.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.2910550403</identifier><identifier>PMID: 8406978</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cohort Studies ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nasopharyngeal Neoplasms - epidemiology ; Otorhinolaryngology. 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A total of 48 NPC deaths were identified during the follow‐up period. Current smokers had a nearly 4‐fold increase in risk of NPC compared with non‐users of any tobacco, with risk increasing to 6.4 among those smoking more than 2 packs daily. After adjustment for age and number of cigarettes smoked, risks were inversely associated with age at starting to smoke, with the highest risk observed among those who started smoking before age 15, although no clear trend associated with duration of smoking was observed. Former cigarette smokers had a small excess risk of NPC, but no association was detected for cigar/pipe users. This study adds strong evidence to the increasing literature linking cigarette smoking to NPC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Neoplasms - epidemiology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Risk</subject><subject>Smoking - adverse effects</subject><subject>Tumors</subject><subject>United States</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxS0EKqWwsiF5QGwpdpwvjyjiU5VYyhxdLmeaKolL3ID632PUqLAx3fB-d_feY-xSirkUIryt1zgPtRRxLCKhjthUCp0GIpTxMZt6QASpVMkpO3NuLYSUHpuwSRaJRKfZlOVLWwKi5YMjDl3FO3B2s4J-170TNByhx7qzLfC648DRrmy_5dZ4nn_Slnro3Dk7MdA4uhjnjL093C_zp2Dx-vic3y0CDLNIBWQq_z_VYKQkCGMERdKUKiGZoHddZmVKkIVAWuhIodKESZVibMBgSErN2M3-7qa3HwO5bdHWDqlpoCM7uCJNhI-qQw_O9yD21rmeTLHp69ZnKqQoflorfGvFb2t-4Wq8PJQtVQd8rMnr16MODqExPjXW7oCp1DsW2mN6j33VDe3-eVo8v-R_LHwDJt6FZQ</recordid><startdate>19931021</startdate><enddate>19931021</enddate><creator>Chow, Wong‐Ho</creator><creator>McLaughlin, Joseph K.</creator><creator>Hrubec, Zdenek</creator><creator>Nam, Jun‐Mo</creator><creator>Blot, William J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931021</creationdate><title>Tobacco use and nasopharyngeal carcinoma in a cohort of us veterans</title><author>Chow, Wong‐Ho ; McLaughlin, Joseph K. ; Hrubec, Zdenek ; Nam, Jun‐Mo ; Blot, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2843-efd01179af11ea25ca3e1fb36e16c109b8b7ea82ae90943c39ec6d7c5fafc2e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Neoplasms - epidemiology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Risk</topic><topic>Smoking - adverse effects</topic><topic>Tumors</topic><topic>United States</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chow, Wong‐Ho</creatorcontrib><creatorcontrib>McLaughlin, Joseph K.</creatorcontrib><creatorcontrib>Hrubec, Zdenek</creatorcontrib><creatorcontrib>Nam, Jun‐Mo</creatorcontrib><creatorcontrib>Blot, William J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chow, Wong‐Ho</au><au>McLaughlin, Joseph K.</au><au>Hrubec, Zdenek</au><au>Nam, Jun‐Mo</au><au>Blot, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tobacco use and nasopharyngeal carcinoma in a cohort of us veterans</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1993-10-21</date><risdate>1993</risdate><volume>55</volume><issue>4</issue><spage>538</spage><epage>540</epage><pages>538-540</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>The risk of nasopharyngeal carcinoma (NPC), a relatively rare neoplasm in the United States, was examined in relation to tobacco use in a cohort of nearly 250,000 US veterans whose mortality experience was followed for 26 years. A total of 48 NPC deaths were identified during the follow‐up period. Current smokers had a nearly 4‐fold increase in risk of NPC compared with non‐users of any tobacco, with risk increasing to 6.4 among those smoking more than 2 packs daily. After adjustment for age and number of cigarettes smoked, risks were inversely associated with age at starting to smoke, with the highest risk observed among those who started smoking before age 15, although no clear trend associated with duration of smoking was observed. Former cigarette smokers had a small excess risk of NPC, but no association was detected for cigar/pipe users. This study adds strong evidence to the increasing literature linking cigarette smoking to NPC.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8406978</pmid><doi>10.1002/ijc.2910550403</doi><tpages>3</tpages></addata></record> |
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| ispartof | International journal of cancer, 1993-10, Vol.55 (4), p.538-540 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adolescent Adult Aged Biological and medical sciences Cohort Studies Female Humans Male Medical sciences Middle Aged Nasopharyngeal Neoplasms - epidemiology Otorhinolaryngology. Stomatology Risk Smoking - adverse effects Tumors United States Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Tobacco use and nasopharyngeal carcinoma in a cohort of us veterans |
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