NITRIC OXIDE PRODUCTION IS INHIBITED IN TRAUMA PATIENTS
Elevated levels of nitrates/nitrites, the stable endproducts of nitric oxide (NO), were recently observed in septic patients. In this setting, NO maintains blood flow by vasodilation and inhibition of platelet aggregation. Trauma patients were found to have low plasma levels of nitrates/nitrites, ev...
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| Veröffentlicht in: | The journal of trauma 1993-10, Vol.35 (4), p.590-597 |
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| container_end_page | 597 |
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| container_issue | 4 |
| container_start_page | 590 |
| container_title | The journal of trauma |
| container_volume | 35 |
| creator | Jacob, Timothy D. Ochoa, Juan B. Udekwu, Anthony O. Wilkinson, J. Murray, T. Billiar, Timothy R. Simmons, Richard L. Marion, Donald W. Peitzman, Andrew B. |
| description | Elevated levels of nitrates/nitrites, the stable endproducts of nitric oxide (NO), were recently observed in septic patients. In this setting, NO maintains blood flow by vasodilation and inhibition of platelet aggregation. Trauma patients were found to have low plasma levels of nitrates/nitrites, even when they developed sepsis. The current study substantiated that trauma patients have suppressed production of NO; reductions in plasma nitrate/nitrite levels correlated with low urinary excretion of these endproducts. Nitric oxide production was upregulated in trauma patients with clinical infection compared with trauma patients without infection, but was still significantly suppressed compared with nitric oxide production in normal controls. The inability of trauma patients to produce NO may be an important component of the susceptibility of these patients to infection. |
| doi_str_mv | 10.1097/00005373-199310000-00015 |
| format | Article |
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In this setting, NO maintains blood flow by vasodilation and inhibition of platelet aggregation. Trauma patients were found to have low plasma levels of nitrates/nitrites, even when they developed sepsis. The current study substantiated that trauma patients have suppressed production of NO; reductions in plasma nitrate/nitrite levels correlated with low urinary excretion of these endproducts. Nitric oxide production was upregulated in trauma patients with clinical infection compared with trauma patients without infection, but was still significantly suppressed compared with nitric oxide production in normal controls. The inability of trauma patients to produce NO may be an important component of the susceptibility of these patients to infection.</description><identifier>ISSN: 0022-5282</identifier><identifier>EISSN: 1529-8809</identifier><identifier>DOI: 10.1097/00005373-199310000-00015</identifier><identifier>PMID: 8411284</identifier><language>eng</language><publisher>United States: Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Creatinine - metabolism ; Female ; Humans ; Kidney - metabolism ; Male ; Middle Aged ; Multiple Trauma - metabolism ; Nitrates - metabolism ; Nitric Oxide - biosynthesis ; Nitric Oxide - metabolism ; Nitrites - metabolism ; Prospective Studies</subject><ispartof>The journal of trauma, 1993-10, Vol.35 (4), p.590-597</ispartof><rights>Williams & Wilkins 1993. 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In this setting, NO maintains blood flow by vasodilation and inhibition of platelet aggregation. Trauma patients were found to have low plasma levels of nitrates/nitrites, even when they developed sepsis. The current study substantiated that trauma patients have suppressed production of NO; reductions in plasma nitrate/nitrite levels correlated with low urinary excretion of these endproducts. Nitric oxide production was upregulated in trauma patients with clinical infection compared with trauma patients without infection, but was still significantly suppressed compared with nitric oxide production in normal controls. The inability of trauma patients to produce NO may be an important component of the susceptibility of these patients to infection.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Creatinine - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Trauma - metabolism</subject><subject>Nitrates - metabolism</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitrites - metabolism</subject><subject>Prospective Studies</subject><issn>0022-5282</issn><issn>1529-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVFPwjAQxxujQUQ_gsmefJu2a0vbxzmmNMGNwEh8a-rWBnQ4XFmI394iyJuXNNfL_3_X3K8ABAjeIyjYA_RBMcMhEgKjfRX6g-gZ6CMaiZBzKM5BH8IoCmnEo0tw5dy7txCCeQ_0OEEo4qQPWCaLmUyC_FWO0mA6y0eLpJB5Fsh5ILOxfJRFOvK3oJjFi5c4mMaFTLNifg0urK6duTnmAVg8pUUyDif5s0ziSVhiTmioqabCMloKIzBHkKEhYpZCgaitLNOVxhiWkHmhtLQk3EBGBBPDqLLab4gH4O4wd9M2X51xW7VeudLUtf40TecUG0KEMYPeyA_Gsm2ca41Vm3a11u23QlDtmak_ZurETP0y8623xze6t7WpTo1HSF4nB33X1FvTuo-625lWLY2ut0v131fgH7BcbxQ</recordid><startdate>199310</startdate><enddate>199310</enddate><creator>Jacob, Timothy D.</creator><creator>Ochoa, Juan B.</creator><creator>Udekwu, Anthony O.</creator><creator>Wilkinson, J.</creator><creator>Murray, T.</creator><creator>Billiar, Timothy R.</creator><creator>Simmons, Richard L.</creator><creator>Marion, Donald W.</creator><creator>Peitzman, Andrew B.</creator><general>Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199310</creationdate><title>NITRIC OXIDE PRODUCTION IS INHIBITED IN TRAUMA PATIENTS</title><author>Jacob, Timothy D. ; Ochoa, Juan B. ; Udekwu, Anthony O. ; Wilkinson, J. ; Murray, T. ; Billiar, Timothy R. ; Simmons, Richard L. ; Marion, Donald W. ; Peitzman, Andrew B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3845-a5a59f75c9e9381071617f50915fdf7ada330c07071cf5c48e07497962dfa0533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Creatinine - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Trauma - metabolism</topic><topic>Nitrates - metabolism</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitrites - metabolism</topic><topic>Prospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Jacob, Timothy D.</creatorcontrib><creatorcontrib>Ochoa, Juan B.</creatorcontrib><creatorcontrib>Udekwu, Anthony O.</creatorcontrib><creatorcontrib>Wilkinson, J.</creatorcontrib><creatorcontrib>Murray, T.</creatorcontrib><creatorcontrib>Billiar, Timothy R.</creatorcontrib><creatorcontrib>Simmons, Richard L.</creatorcontrib><creatorcontrib>Marion, Donald W.</creatorcontrib><creatorcontrib>Peitzman, Andrew B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of trauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacob, Timothy D.</au><au>Ochoa, Juan B.</au><au>Udekwu, Anthony O.</au><au>Wilkinson, J.</au><au>Murray, T.</au><au>Billiar, Timothy R.</au><au>Simmons, Richard L.</au><au>Marion, Donald W.</au><au>Peitzman, Andrew B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NITRIC OXIDE PRODUCTION IS INHIBITED IN TRAUMA PATIENTS</atitle><jtitle>The journal of trauma</jtitle><addtitle>J Trauma</addtitle><date>1993-10</date><risdate>1993</risdate><volume>35</volume><issue>4</issue><spage>590</spage><epage>597</epage><pages>590-597</pages><issn>0022-5282</issn><eissn>1529-8809</eissn><abstract>Elevated levels of nitrates/nitrites, the stable endproducts of nitric oxide (NO), were recently observed in septic patients. 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| identifier | ISSN: 0022-5282 |
| ispartof | The journal of trauma, 1993-10, Vol.35 (4), p.590-597 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Creatinine - metabolism Female Humans Kidney - metabolism Male Middle Aged Multiple Trauma - metabolism Nitrates - metabolism Nitric Oxide - biosynthesis Nitric Oxide - metabolism Nitrites - metabolism Prospective Studies |
| title | NITRIC OXIDE PRODUCTION IS INHIBITED IN TRAUMA PATIENTS |
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