Does Gγ/Aγ ratio and Hb F level influence the severity of sickle cell anaemia
Sickle cell anaemia (SCA) exhibits significant variations in clinical presentation in different populations for which several genetic factors including SCA-associated alpha- and beta-thalassaemias, G-6-PD deficiency and elevated Hb F level have been implicated as possible ameliorating factors. Saudi...
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| Veröffentlicht in: | Molecular and cellular biochemistry 1993-07, Vol.124 (1), p.17-22 |
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| creator | EL-HAZMI, M. A. F BAHAKIM, H. M WARSY, A. S ABDULKARIM AL-MOMEN ABDULLAH AL-WAZZAN IBRAHIM AL-FAWWAZ SAMEER HURAIB MOHAMMAD HARAKATI |
| description | Sickle cell anaemia (SCA) exhibits significant variations in clinical presentation in different populations for which several genetic factors including SCA-associated alpha- and beta-thalassaemias, G-6-PD deficiency and elevated Hb F level have been implicated as possible ameliorating factors. Saudi Arabia is unique in that mild and severe forms of the disease occur at a high frequency. We investigated the G gamma/A gamma ratio and Hb F level and correlated these values with the severity of SCA. The results showed that Hb F level varies significantly in both groups of patients with no evident correlation with the mild clinical manifestations. However, G gamma/A gamma ratio correlated significantly with the disease severity where a high ratio was observed in patients with the mild and a low ratio in patients with the severe disease. The results are evaluated and discussed in the light of correlation studies and regression analysis. |
| doi_str_mv | 10.1007/BF01096377 |
| format | Article |
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A. F ; BAHAKIM, H. M ; WARSY, A. S ; ABDULKARIM AL-MOMEN ; ABDULLAH AL-WAZZAN ; IBRAHIM AL-FAWWAZ ; SAMEER HURAIB ; MOHAMMAD HARAKATI</creator><creatorcontrib>EL-HAZMI, M. A. F ; BAHAKIM, H. M ; WARSY, A. S ; ABDULKARIM AL-MOMEN ; ABDULLAH AL-WAZZAN ; IBRAHIM AL-FAWWAZ ; SAMEER HURAIB ; MOHAMMAD HARAKATI</creatorcontrib><description>Sickle cell anaemia (SCA) exhibits significant variations in clinical presentation in different populations for which several genetic factors including SCA-associated alpha- and beta-thalassaemias, G-6-PD deficiency and elevated Hb F level have been implicated as possible ameliorating factors. Saudi Arabia is unique in that mild and severe forms of the disease occur at a high frequency. We investigated the G gamma/A gamma ratio and Hb F level and correlated these values with the severity of SCA. The results showed that Hb F level varies significantly in both groups of patients with no evident correlation with the mild clinical manifestations. However, G gamma/A gamma ratio correlated significantly with the disease severity where a high ratio was observed in patients with the mild and a low ratio in patients with the severe disease. The results are evaluated and discussed in the light of correlation studies and regression analysis.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/BF01096377</identifier><identifier>PMID: 7694072</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Anemia, Sickle Cell - metabolism ; Anemia, Sickle Cell - physiopathology ; Anemias. 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A. F</creatorcontrib><creatorcontrib>BAHAKIM, H. M</creatorcontrib><creatorcontrib>WARSY, A. S</creatorcontrib><creatorcontrib>ABDULKARIM AL-MOMEN</creatorcontrib><creatorcontrib>ABDULLAH AL-WAZZAN</creatorcontrib><creatorcontrib>IBRAHIM AL-FAWWAZ</creatorcontrib><creatorcontrib>SAMEER HURAIB</creatorcontrib><creatorcontrib>MOHAMMAD HARAKATI</creatorcontrib><title>Does Gγ/Aγ ratio and Hb F level influence the severity of sickle cell anaemia</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>Sickle cell anaemia (SCA) exhibits significant variations in clinical presentation in different populations for which several genetic factors including SCA-associated alpha- and beta-thalassaemias, G-6-PD deficiency and elevated Hb F level have been implicated as possible ameliorating factors. Saudi Arabia is unique in that mild and severe forms of the disease occur at a high frequency. We investigated the G gamma/A gamma ratio and Hb F level and correlated these values with the severity of SCA. The results showed that Hb F level varies significantly in both groups of patients with no evident correlation with the mild clinical manifestations. However, G gamma/A gamma ratio correlated significantly with the disease severity where a high ratio was observed in patients with the mild and a low ratio in patients with the severe disease. The results are evaluated and discussed in the light of correlation studies and regression analysis.</description><subject>Anemia, Sickle Cell - metabolism</subject><subject>Anemia, Sickle Cell - physiopathology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Diseases of red blood cells</subject><subject>Fetal Hemoglobin - metabolism</subject><subject>Globins - chemistry</subject><subject>Globins - genetics</subject><subject>Globins - metabolism</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Regression Analysis</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFKw0AQhhdRaq1evAt7EG-xM9kkmz1qta1Q6EXPYZOd4OomqdlE6HP1PfpMRgyeBub7_mH4GbtGuEcAOX9cAoJKhJQnbIqxFEGkUJ2yKQiAIEUpz9mF9x8waIA4YROZqAhkOGXbp4Y8Xx0P84fjgbe6sw3XteHrnC-5o29y3Nal66kuiHfvxP2wa223503JvS0-HfGCnBtCmiqrL9lZqZ2nq3HO2Nvy-XWxDjbb1cviYRPsQhF3gdSlSQ1IbQohKJdoICni0IgITEqqjAgVkCxDo1MgFWMaRrlKEGUspc5RzNjd391d23z15Lussv73EV1T0_tMJoACEzGIN6PY5xWZbNfaSrf7bGxg4Lcj177Qrmx1XVj_r0VpEiLE4gefoWie</recordid><startdate>19930707</startdate><enddate>19930707</enddate><creator>EL-HAZMI, M. A. F</creator><creator>BAHAKIM, H. M</creator><creator>WARSY, A. S</creator><creator>ABDULKARIM AL-MOMEN</creator><creator>ABDULLAH AL-WAZZAN</creator><creator>IBRAHIM AL-FAWWAZ</creator><creator>SAMEER HURAIB</creator><creator>MOHAMMAD HARAKATI</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930707</creationdate><title>Does Gγ/Aγ ratio and Hb F level influence the severity of sickle cell anaemia</title><author>EL-HAZMI, M. A. F ; BAHAKIM, H. M ; WARSY, A. S ; ABDULKARIM AL-MOMEN ; ABDULLAH AL-WAZZAN ; IBRAHIM AL-FAWWAZ ; SAMEER HURAIB ; MOHAMMAD HARAKATI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-7afd8d07adc33eb71d06c52d340d8e9f4e190e7f2da80e951824b96117577ab13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Anemia, Sickle Cell - metabolism</topic><topic>Anemia, Sickle Cell - physiopathology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Diseases of red blood cells</topic><topic>Fetal Hemoglobin - metabolism</topic><topic>Globins - chemistry</topic><topic>Globins - genetics</topic><topic>Globins - metabolism</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EL-HAZMI, M. A. F</creatorcontrib><creatorcontrib>BAHAKIM, H. M</creatorcontrib><creatorcontrib>WARSY, A. S</creatorcontrib><creatorcontrib>ABDULKARIM AL-MOMEN</creatorcontrib><creatorcontrib>ABDULLAH AL-WAZZAN</creatorcontrib><creatorcontrib>IBRAHIM AL-FAWWAZ</creatorcontrib><creatorcontrib>SAMEER HURAIB</creatorcontrib><creatorcontrib>MOHAMMAD HARAKATI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EL-HAZMI, M. A. F</au><au>BAHAKIM, H. M</au><au>WARSY, A. S</au><au>ABDULKARIM AL-MOMEN</au><au>ABDULLAH AL-WAZZAN</au><au>IBRAHIM AL-FAWWAZ</au><au>SAMEER HURAIB</au><au>MOHAMMAD HARAKATI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Gγ/Aγ ratio and Hb F level influence the severity of sickle cell anaemia</atitle><jtitle>Molecular and cellular biochemistry</jtitle><addtitle>Mol Cell Biochem</addtitle><date>1993-07-07</date><risdate>1993</risdate><volume>124</volume><issue>1</issue><spage>17</spage><epage>22</epage><pages>17-22</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Sickle cell anaemia (SCA) exhibits significant variations in clinical presentation in different populations for which several genetic factors including SCA-associated alpha- and beta-thalassaemias, G-6-PD deficiency and elevated Hb F level have been implicated as possible ameliorating factors. Saudi Arabia is unique in that mild and severe forms of the disease occur at a high frequency. We investigated the G gamma/A gamma ratio and Hb F level and correlated these values with the severity of SCA. The results showed that Hb F level varies significantly in both groups of patients with no evident correlation with the mild clinical manifestations. However, G gamma/A gamma ratio correlated significantly with the disease severity where a high ratio was observed in patients with the mild and a low ratio in patients with the severe disease. The results are evaluated and discussed in the light of correlation studies and regression analysis.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>7694072</pmid><doi>10.1007/BF01096377</doi><tpages>6</tpages></addata></record> |
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| ispartof | Molecular and cellular biochemistry, 1993-07, Vol.124 (1), p.17-22 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Anemia, Sickle Cell - metabolism Anemia, Sickle Cell - physiopathology Anemias. Hemoglobinopathies Biological and medical sciences Diseases of red blood cells Fetal Hemoglobin - metabolism Globins - chemistry Globins - genetics Globins - metabolism Hematologic and hematopoietic diseases Humans Medical sciences Regression Analysis |
| title | Does Gγ/Aγ ratio and Hb F level influence the severity of sickle cell anaemia |
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