Mechanism of action of indomethacin in tubular defects

Indomethacin, a potent prostaglandin synthesis inhibitor, has been proven to be effective in a number of tubular defects characterized by enhanced prostaglandin (namely, prostaglandin E2 (PGE2) production, but its mechanism of action is poorly understood. To elucidate further the mechanism(s) by whi...

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Veröffentlicht in:	Pediatrics (Evanston) 1985-03, Vol.75 (3), p.501-507
Hauptverfasser:	USBERTI, M, PECORARO, C, FEDERICO, S, CIANCIARUSO, B, GUIDA, B, ROMANO, A, GRUMETTO, L, CARBONARO, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Aldosterone - blood Biological and medical sciences Child Child, Preschool Diabetes Insipidus - drug therapy Diabetes Insipidus - etiology Diabetes Insipidus - physiopathology Dinoprostone Fanconi Anemia - complications Fanconi Anemia - drug therapy Follow-Up Studies Humans Indomethacin - pharmacology Indomethacin - therapeutic use Infant Kidney Diseases - complications Kidney Diseases - drug therapy Kidney Diseases - physiopathology Kidney Function Tests Kidney Tubules - physiopathology Male Medical sciences Pharmacology. Drug treatments Prostaglandins E - urine Urinary system
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