Generation of activated protein C during thrombolysis

The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during...

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Veröffentlicht in:	The Lancet (British edition) 1993-11, Vol.342 (8882), p.1275-1276
Hauptverfasser:	Gruber, A., Griffin, J.H., Pál, A., Sas, G., Kiss, R.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated protein C Aged Anticoagulants Baboons Biological and medical sciences Blood Blood. Blood coagulation. Reticuloendothelial system Catheters Enzyme Activation - drug effects Enzymes Female Fibrin Humans Male Medical research Medical sciences Middle Aged Monkeys & apes Myocardial Infarction - blood Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Pharmacology. Drug treatments Plasmin Protein C - analysis Protein C - biosynthesis Protein C - metabolism Protein C Inhibitor - blood Proteins Streptokinase Streptokinase - pharmacology Streptokinase - therapeutic use Therapy Thrombolysis Thrombolytic Therapy U-Plasminogen activator Urokinase
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