Generation of activated protein C during thrombolysis
The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during...
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| Veröffentlicht in: | The Lancet (British edition) 1993-11, Vol.342 (8882), p.1275-1276 |
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| container_issue | 8882 |
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| container_title | The Lancet (British edition) |
| container_volume | 342 |
| creator | Gruber, A. Griffin, J.H. Pál, A. Sas, G. Kiss, R.G. |
| description | The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation—the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis. |
| doi_str_mv | 10.1016/0140-6736(93)92364-Y |
| format | Article |
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Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation—the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(93)92364-Y</identifier><identifier>PMID: 7901587</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Activated protein C ; Aged ; Anticoagulants ; Baboons ; Biological and medical sciences ; Blood ; Blood. Blood coagulation. Reticuloendothelial system ; Catheters ; Enzyme Activation - drug effects ; Enzymes ; Female ; Fibrin ; Humans ; Male ; Medical research ; Medical sciences ; Middle Aged ; Monkeys & apes ; Myocardial Infarction - blood ; Myocardial Infarction - drug therapy ; Myocardial Infarction - metabolism ; Pharmacology. Drug treatments ; Plasmin ; Protein C - analysis ; Protein C - biosynthesis ; Protein C - metabolism ; Protein C Inhibitor - blood ; Proteins ; Streptokinase ; Streptokinase - pharmacology ; Streptokinase - therapeutic use ; Therapy ; Thrombolysis ; Thrombolytic Therapy ; U-Plasminogen activator ; Urokinase</subject><ispartof>The Lancet (British edition), 1993-11, Vol.342 (8882), p.1275-1276</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Nov 20, 1993</rights><rights>Copyright Elsevier Limited Nov 20, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-244e66a33ef9a2bc951d226759d5580c4c3f544886fe285673bc6639cb6956243</citedby><cites>FETCH-LOGICAL-c441t-244e66a33ef9a2bc951d226759d5580c4c3f544886fe285673bc6639cb6956243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/198953163?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3823433$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7901587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruber, A.</creatorcontrib><creatorcontrib>Griffin, J.H.</creatorcontrib><creatorcontrib>Pál, A.</creatorcontrib><creatorcontrib>Sas, G.</creatorcontrib><creatorcontrib>Kiss, R.G.</creatorcontrib><title>Generation of activated protein C during thrombolysis</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation—the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.</description><subject>Activated protein C</subject><subject>Aged</subject><subject>Anticoagulants</subject><subject>Baboons</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Catheters</subject><subject>Enzyme Activation - drug effects</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fibrin</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monkeys & apes</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmin</subject><subject>Protein C - analysis</subject><subject>Protein C - biosynthesis</subject><subject>Protein C - metabolism</subject><subject>Protein C Inhibitor - blood</subject><subject>Proteins</subject><subject>Streptokinase</subject><subject>Streptokinase - pharmacology</subject><subject>Streptokinase - therapeutic use</subject><subject>Therapy</subject><subject>Thrombolysis</subject><subject>Thrombolytic Therapy</subject><subject>U-Plasminogen activator</subject><subject>Urokinase</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMtKxDAUhoMoOl7eQKGoiC6quTfZCDJ4A8GNgq5Cmp5qpNNo0gq-va0zzELQ1Vmc7z_n50Nol-BTgok8w4TjXBZMHmt2oimTPH9eQRPCC54LXjytoskS2UCbKb1hjLnEYh2tFxoToYoJEtfQQrSdD20W6sy6zn_aDqrsPYYOfJtNs6qPvn3JutcYZmVovpJP22ittk2CncXcQo9Xlw_Tm_zu_vp2enGXO85Jl1POQUrLGNTa0tJpQSpKZSF0JYTCjjtWC86VkjVQJYaipZOSaVdKLSTlbAsdze8ObT56SJ2Z-eSgaWwLoU-mkBhrQcUAHvwC30If26GboUSQgiqt2EDt_0URrbRgRI4Qn0MuhpQi1OY9-pmNX4ZgM4o3o1UzWjWamR_x5nmI7S1u9-UMqmVoYXrYHy72Njnb1NG2zqclxhRlnI3fz-cYDFo_PUSTnIfWQeUjuM5Uwf_f4xtULJum</recordid><startdate>19931120</startdate><enddate>19931120</enddate><creator>Gruber, A.</creator><creator>Griffin, J.H.</creator><creator>Pál, A.</creator><creator>Sas, G.</creator><creator>Kiss, R.G.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19931120</creationdate><title>Generation of activated protein C during thrombolysis</title><author>Gruber, A. ; Griffin, J.H. ; Pál, A. ; Sas, G. ; Kiss, R.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-244e66a33ef9a2bc951d226759d5580c4c3f544886fe285673bc6639cb6956243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Activated protein C</topic><topic>Aged</topic><topic>Anticoagulants</topic><topic>Baboons</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Catheters</topic><topic>Enzyme Activation - drug effects</topic><topic>Enzymes</topic><topic>Female</topic><topic>Fibrin</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monkeys & apes</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - metabolism</topic><topic>Pharmacology. 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruber, A.</au><au>Griffin, J.H.</au><au>Pál, A.</au><au>Sas, G.</au><au>Kiss, R.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generation of activated protein C during thrombolysis</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1993-11-20</date><risdate>1993</risdate><volume>342</volume><issue>8882</issue><spage>1275</spage><epage>1276</epage><pages>1275-1276</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation—the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7901587</pmid><doi>10.1016/0140-6736(93)92364-Y</doi><tpages>2</tpages></addata></record> |
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| subjects | Activated protein C Aged Anticoagulants Baboons Biological and medical sciences Blood Blood. Blood coagulation. Reticuloendothelial system Catheters Enzyme Activation - drug effects Enzymes Female Fibrin Humans Male Medical research Medical sciences Middle Aged Monkeys & apes Myocardial Infarction - blood Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Pharmacology. Drug treatments Plasmin Protein C - analysis Protein C - biosynthesis Protein C - metabolism Protein C Inhibitor - blood Proteins Streptokinase Streptokinase - pharmacology Streptokinase - therapeutic use Therapy Thrombolysis Thrombolytic Therapy U-Plasminogen activator Urokinase |
| title | Generation of activated protein C during thrombolysis |
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