Absence of Agonist Effects of High-Dose Flumazenil on Ventilation and Psychometric Performance in Human Volunteers

Flumazenil, a specific benzodiazepine antagonist, reverses sedative and respiratory depressant effects of benzodiazepines. We determined whether a large dose of flumazenil, injected alone, induces respiratory depression or alteration of psychomotor performance. After informed consent, eight healthy...

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