Modulation of human t cell responses by nitric oxide and its derivative, s‐nitrosoglutathione

Objective. To examine the effects of nitric oxide (NO) and its more stable derivative, S‐nitrosoglutathione (SNO‐GSH), on the response of activated T lymphocytes. Methods. The effects of NO and SNO‐GSH on DNA synthesis, interleukin‐2 (IL‐2) production, IL‐2 receptor expression, and cGMP accumulation...

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Veröffentlicht in:	Arthritis and rheumatism 1993-10, Vol.36 (10), p.1414-1422
Hauptverfasser:	Merryman, Parvin F., Clancy, Robert M., He, Xiao Yuen, Abramson, Steven B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cyclic GMP - metabolism DNA - antagonists & inhibitors DNA - biosynthesis Fundamental and applied biological sciences. Psychology Fundamental immunology Glutathione - analogs & derivatives Glutathione - pharmacology Humans Immunobiology Interleukin-2 - biosynthesis Macrophages - physiology Modulation of the immune response (stimulation, suppression) Monocytes - drug effects Monocytes - metabolism Nitric Oxide - antagonists & inhibitors Nitric Oxide - pharmacology Nitroso Compounds - pharmacology S-Nitrosoglutathione Spleen - cytology Spleen - metabolism T-Lymphocytes - drug effects T-Lymphocytes - metabolism Time Factors
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