Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children
During routine monitoring of hospitalized children with asthma receiving a sustained-release theophylline formulation, we frequently observe unpredictable fluctuations in serum theophylline concentration (STC). We evaluated eight asthmatic patients (ages 4 to 17 years) with inconsistent STCs to dete...
Gespeichert in:
| Veröffentlicht in: | The Journal of pediatrics 1985-03, Vol.106 (3), p.496-501 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 501 |
|---|---|
| container_issue | 3 |
| container_start_page | 496 |
| container_title | The Journal of pediatrics |
| container_volume | 106 |
| creator | ROGERS, R. J KALISKER, A WIENER, M. B SZEFLER, S. J |
| description | During routine monitoring of hospitalized children with asthma receiving a sustained-release theophylline formulation, we frequently observe unpredictable fluctuations in serum theophylline concentration (STC). We evaluated eight asthmatic patients (ages 4 to 17 years) with inconsistent STCs to determine the cause of this phenomenon. Only minimal variation in STC and therefore theophylline clearance was noted during a 24-hour period of continuous intravenous aminophylline infusion. However, marked variability in STC was observed when measured every 2 hours for 48 hours after 6 days of continuous therapy orally. In addition, the time required to reach peak and trough STCs varied from dose to dose. Inasmuch as clearance was shown to be constant, the variability was attributed to inconsistent theophylline absorption. Unpredictable fluctuations of STC secondary to variable absorption from this sustained-release theophylline preparation may occur in certain patients. Appreciation of this potential variability is necessary for the proper interpretation of STC measurements and subsequent dosage adjustment. |
| doi_str_mv | 10.1016/S0022-3476(85)80690-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_76004010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76004010</sourcerecordid><originalsourceid>FETCH-LOGICAL-p167t-57b31dfc23210327eca2afe6fa85923bb3ba24aaecd8bc916951ed7576506423</originalsourceid><addsrcrecordid>eNo9kMFq3DAQhkVo2Wy2fYQFHUJJDm5Hki1Zx7Ck7cJCD937MpbHWRVbdiX5sG8fN11yGpj_m4_hZ2wr4KsAob_9BpCyUKXRD3X1WIO2UNgbthZgTaFrpT6w9Ttyy-5S-gMAtgRYsZWyRpm6XrPLPrgxJJ8yhcyxSWOcsh8D7-I4cORpThl9oLaI1BMm4vlM43S-9P2y5VOkCSO-XbRz9OGFL7rswzzO6R8acbpwHzimfB4WznF39n0bKXxiHzvsE32-zg07fn8-7n4Wh18_9runQzEJbXJRmUaJtnNSSQFKGnIosSPdYV1ZqZpGNShLRHJt3TgrtK0EtaYyugJdSrVhX_5rpzj-nSnl0-CTo77HQMuPJ6MBSljUG7a9gnMzUHuaoh8wXk7Xqpb8_ppjcth3EYPz6R2z0mohhHoFgt98pg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76004010</pqid></control><display><type>article</type><title>Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>ROGERS, R. J ; KALISKER, A ; WIENER, M. B ; SZEFLER, S. J</creator><creatorcontrib>ROGERS, R. J ; KALISKER, A ; WIENER, M. B ; SZEFLER, S. J</creatorcontrib><description>During routine monitoring of hospitalized children with asthma receiving a sustained-release theophylline formulation, we frequently observe unpredictable fluctuations in serum theophylline concentration (STC). We evaluated eight asthmatic patients (ages 4 to 17 years) with inconsistent STCs to determine the cause of this phenomenon. Only minimal variation in STC and therefore theophylline clearance was noted during a 24-hour period of continuous intravenous aminophylline infusion. However, marked variability in STC was observed when measured every 2 hours for 48 hours after 6 days of continuous therapy orally. In addition, the time required to reach peak and trough STCs varied from dose to dose. Inasmuch as clearance was shown to be constant, the variability was attributed to inconsistent theophylline absorption. Unpredictable fluctuations of STC secondary to variable absorption from this sustained-release theophylline preparation may occur in certain patients. Appreciation of this potential variability is necessary for the proper interpretation of STC measurements and subsequent dosage adjustment.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(85)80690-9</identifier><identifier>PMID: 3973788</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Adolescent ; Aminophylline - administration & dosage ; Asthma - drug therapy ; Asthma - metabolism ; Biological and medical sciences ; Biological Availability ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid ; Delayed-Action Preparations ; Female ; Half-Life ; Humans ; Infusions, Parenteral ; Intestinal Absorption ; Kinetics ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Respiratory system ; Tablets ; Theophylline - administration & dosage ; Theophylline - blood ; Theophylline - metabolism</subject><ispartof>The Journal of pediatrics, 1985-03, Vol.106 (3), p.496-501</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9296111$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3973788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROGERS, R. J</creatorcontrib><creatorcontrib>KALISKER, A</creatorcontrib><creatorcontrib>WIENER, M. B</creatorcontrib><creatorcontrib>SZEFLER, S. J</creatorcontrib><title>Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>During routine monitoring of hospitalized children with asthma receiving a sustained-release theophylline formulation, we frequently observe unpredictable fluctuations in serum theophylline concentration (STC). We evaluated eight asthmatic patients (ages 4 to 17 years) with inconsistent STCs to determine the cause of this phenomenon. Only minimal variation in STC and therefore theophylline clearance was noted during a 24-hour period of continuous intravenous aminophylline infusion. However, marked variability in STC was observed when measured every 2 hours for 48 hours after 6 days of continuous therapy orally. In addition, the time required to reach peak and trough STCs varied from dose to dose. Inasmuch as clearance was shown to be constant, the variability was attributed to inconsistent theophylline absorption. Unpredictable fluctuations of STC secondary to variable absorption from this sustained-release theophylline preparation may occur in certain patients. Appreciation of this potential variability is necessary for the proper interpretation of STC measurements and subsequent dosage adjustment.</description><subject>Adolescent</subject><subject>Aminophylline - administration & dosage</subject><subject>Asthma - drug therapy</subject><subject>Asthma - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Delayed-Action Preparations</subject><subject>Female</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Infusions, Parenteral</subject><subject>Intestinal Absorption</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiratory system</subject><subject>Tablets</subject><subject>Theophylline - administration & dosage</subject><subject>Theophylline - blood</subject><subject>Theophylline - metabolism</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFq3DAQhkVo2Wy2fYQFHUJJDm5Hki1Zx7Ck7cJCD937MpbHWRVbdiX5sG8fN11yGpj_m4_hZ2wr4KsAob_9BpCyUKXRD3X1WIO2UNgbthZgTaFrpT6w9Ttyy-5S-gMAtgRYsZWyRpm6XrPLPrgxJJ8yhcyxSWOcsh8D7-I4cORpThl9oLaI1BMm4vlM43S-9P2y5VOkCSO-XbRz9OGFL7rswzzO6R8acbpwHzimfB4WznF39n0bKXxiHzvsE32-zg07fn8-7n4Wh18_9runQzEJbXJRmUaJtnNSSQFKGnIosSPdYV1ZqZpGNShLRHJt3TgrtK0EtaYyugJdSrVhX_5rpzj-nSnl0-CTo77HQMuPJ6MBSljUG7a9gnMzUHuaoh8wXk7Xqpb8_ppjcth3EYPz6R2z0mohhHoFgt98pg</recordid><startdate>198503</startdate><enddate>198503</enddate><creator>ROGERS, R. J</creator><creator>KALISKER, A</creator><creator>WIENER, M. B</creator><creator>SZEFLER, S. J</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198503</creationdate><title>Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children</title><author>ROGERS, R. J ; KALISKER, A ; WIENER, M. B ; SZEFLER, S. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p167t-57b31dfc23210327eca2afe6fa85923bb3ba24aaecd8bc916951ed7576506423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Aminophylline - administration & dosage</topic><topic>Asthma - drug therapy</topic><topic>Asthma - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Delayed-Action Preparations</topic><topic>Female</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Infusions, Parenteral</topic><topic>Intestinal Absorption</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiratory system</topic><topic>Tablets</topic><topic>Theophylline - administration & dosage</topic><topic>Theophylline - blood</topic><topic>Theophylline - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROGERS, R. J</creatorcontrib><creatorcontrib>KALISKER, A</creatorcontrib><creatorcontrib>WIENER, M. B</creatorcontrib><creatorcontrib>SZEFLER, S. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROGERS, R. J</au><au>KALISKER, A</au><au>WIENER, M. B</au><au>SZEFLER, S. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1985-03</date><risdate>1985</risdate><volume>106</volume><issue>3</issue><spage>496</spage><epage>501</epage><pages>496-501</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>During routine monitoring of hospitalized children with asthma receiving a sustained-release theophylline formulation, we frequently observe unpredictable fluctuations in serum theophylline concentration (STC). We evaluated eight asthmatic patients (ages 4 to 17 years) with inconsistent STCs to determine the cause of this phenomenon. Only minimal variation in STC and therefore theophylline clearance was noted during a 24-hour period of continuous intravenous aminophylline infusion. However, marked variability in STC was observed when measured every 2 hours for 48 hours after 6 days of continuous therapy orally. In addition, the time required to reach peak and trough STCs varied from dose to dose. Inasmuch as clearance was shown to be constant, the variability was attributed to inconsistent theophylline absorption. Unpredictable fluctuations of STC secondary to variable absorption from this sustained-release theophylline preparation may occur in certain patients. Appreciation of this potential variability is necessary for the proper interpretation of STC measurements and subsequent dosage adjustment.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>3973788</pmid><doi>10.1016/S0022-3476(85)80690-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1985-03, Vol.106 (3), p.496-501 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76004010 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Aminophylline - administration & dosage Asthma - drug therapy Asthma - metabolism Biological and medical sciences Biological Availability Child Child, Preschool Chromatography, High Pressure Liquid Delayed-Action Preparations Female Half-Life Humans Infusions, Parenteral Intestinal Absorption Kinetics Male Medical sciences Pharmacology. Drug treatments Respiratory system Tablets Theophylline - administration & dosage Theophylline - blood Theophylline - metabolism |
| title | Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T06%3A47%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inconsistent%20absorption%20from%20a%20sustained-release%20theophylline%20preparation%20during%20continuous%20therapy%20in%20asthmatic%20children&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=ROGERS,%20R.%20J&rft.date=1985-03&rft.volume=106&rft.issue=3&rft.spage=496&rft.epage=501&rft.pages=496-501&rft.issn=0022-3476&rft.eissn=1097-6833&rft.coden=JOPDAB&rft_id=info:doi/10.1016/S0022-3476(85)80690-9&rft_dat=%3Cproquest_pubme%3E76004010%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76004010&rft_id=info:pmid/3973788&rfr_iscdi=true |