[17] Meizothrombin: Active intermediate formed during prothrombinase-catalyzed activation of prothrombin

This chapter focuses on the active intermediate formed during the prothrombinase-catalyzed activation of prothrombin. The activation of prothrombin to thrombin proceeds via the cleavage of two peptide bonds in the prothrombin molecule. These bonds are cleaved by the prothrombinase enzyme complex tha...

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Veröffentlicht in:	Methods in Enzymology 1993, Vol.222, p.299-312
Hauptverfasser:	Doyle, Margaret F., Haley, Paul E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Blood Coagulation Tests - methods Electrophoresis, Polyacrylamide Gel - methods Enzyme Precursors - analysis Enzyme Precursors - metabolism Enzyme Precursors - pharmacology Esterases - metabolism Factor V - metabolism Factor Va - metabolism Femoral Artery - drug effects Femoral Artery - physiology Humans In Vitro Techniques Indicators and Reagents Kinetics Male Models, Biological Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Platelet Activation - drug effects Platelet Aggregation - drug effects Protein C - metabolism Prothrombin - metabolism Rabbits Spectrophotometry - methods Substrate Specificity Thrombin - analysis Thrombin - metabolism Thrombin - pharmacology Thromboplastin - metabolism
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