Chronic lymphocytic leukemia with CNS involvement
Direct involvement of the brain by chronic lymphocytic leukemia (CLL) is extremely rare. This is the second documented case. A 63 year-old-man presented with motor deficits. Conventional radiographic imaging showed no abnormalities but an MRI scan of the head showed a high signal intensity lesion in...
Gespeichert in:
| Veröffentlicht in: | Journal of neuro-oncology 1993-04, Vol.16 (1), p.35-37 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 37 |
|---|---|
| container_issue | 1 |
| container_start_page | 35 |
| container_title | Journal of neuro-oncology |
| container_volume | 16 |
| creator | SURJEET POHAR DEMETZ, C POPPEMA, S HUGH, J |
| description | Direct involvement of the brain by chronic lymphocytic leukemia (CLL) is extremely rare. This is the second documented case. A 63 year-old-man presented with motor deficits. Conventional radiographic imaging showed no abnormalities but an MRI scan of the head showed a high signal intensity lesion in the left cerebellum. Biopsy of this area showed a perivascular infiltrate of small B lymphocytes consistent with CLL involvement. The patient was treated with radiotherapy and had some improvement in symptoms. Three years later he remains alive with some neurologic deficit. This case confirms that CLL can be complicated by direct brain involvement. |
| doi_str_mv | 10.1007/BF01324832 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76001791</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76001791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-4bfc7ad4669b54c794c77f637cc380961e5474100ce399ca1bd33948a8fcb0363</originalsourceid><addsrcrecordid>eNpFkE1Lw0AQhhdRaq1evAs5iAchOtPZ7GaPGqwKRQ8qeAub7YZG81F3k0r_vSkN9TDMwPvwMjyMnSPcIIC8vZ8B0pTHND1gY4wkhZIkHbIxoJBhpPjnMTvx_gsAuCQcsVHMEZDDmGGydE1dmKDcVKtlYzbt9rbdt60KHfwW7TJIXt6Col435dpWtm5P2VGuS2_Phj1hH7OH9-QpnL8-Pid389AQYhvyLDdSL7gQKou4kaofmQuSxlAMSqCNuOy_AGNJKaMxWxApHus4NxmQoAm72vWuXPPTWd-mVeGNLUtd26bzqRQAKBX24PUONK7x3tk8Xbmi0m6TIqRbP-m_nx6-GFq7rLKLPToI6fPLIdfe6DJ3ujaF32NcAQc-pT-Gc2qo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76001791</pqid></control><display><type>article</type><title>Chronic lymphocytic leukemia with CNS involvement</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>SURJEET POHAR ; DEMETZ, C ; POPPEMA, S ; HUGH, J</creator><creatorcontrib>SURJEET POHAR ; DEMETZ, C ; POPPEMA, S ; HUGH, J</creatorcontrib><description>Direct involvement of the brain by chronic lymphocytic leukemia (CLL) is extremely rare. This is the second documented case. A 63 year-old-man presented with motor deficits. Conventional radiographic imaging showed no abnormalities but an MRI scan of the head showed a high signal intensity lesion in the left cerebellum. Biopsy of this area showed a perivascular infiltrate of small B lymphocytes consistent with CLL involvement. The patient was treated with radiotherapy and had some improvement in symptoms. Three years later he remains alive with some neurologic deficit. This case confirms that CLL can be complicated by direct brain involvement.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/BF01324832</identifier><identifier>PMID: 8410140</identifier><identifier>CODEN: JNODD2</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Biological and medical sciences ; Brain - pathology ; Hematologic and hematopoietic diseases ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukemic Infiltration ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged</subject><ispartof>Journal of neuro-oncology, 1993-04, Vol.16 (1), p.35-37</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-4bfc7ad4669b54c794c77f637cc380961e5474100ce399ca1bd33948a8fcb0363</citedby><cites>FETCH-LOGICAL-c311t-4bfc7ad4669b54c794c77f637cc380961e5474100ce399ca1bd33948a8fcb0363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4904042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8410140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SURJEET POHAR</creatorcontrib><creatorcontrib>DEMETZ, C</creatorcontrib><creatorcontrib>POPPEMA, S</creatorcontrib><creatorcontrib>HUGH, J</creatorcontrib><title>Chronic lymphocytic leukemia with CNS involvement</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><description>Direct involvement of the brain by chronic lymphocytic leukemia (CLL) is extremely rare. This is the second documented case. A 63 year-old-man presented with motor deficits. Conventional radiographic imaging showed no abnormalities but an MRI scan of the head showed a high signal intensity lesion in the left cerebellum. Biopsy of this area showed a perivascular infiltrate of small B lymphocytes consistent with CLL involvement. The patient was treated with radiotherapy and had some improvement in symptoms. Three years later he remains alive with some neurologic deficit. This case confirms that CLL can be complicated by direct brain involvement.</description><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukemic Infiltration</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAs5iAchOtPZ7GaPGqwKRQ8qeAub7YZG81F3k0r_vSkN9TDMwPvwMjyMnSPcIIC8vZ8B0pTHND1gY4wkhZIkHbIxoJBhpPjnMTvx_gsAuCQcsVHMEZDDmGGydE1dmKDcVKtlYzbt9rbdt60KHfwW7TJIXt6Col435dpWtm5P2VGuS2_Phj1hH7OH9-QpnL8-Pid389AQYhvyLDdSL7gQKou4kaofmQuSxlAMSqCNuOy_AGNJKaMxWxApHus4NxmQoAm72vWuXPPTWd-mVeGNLUtd26bzqRQAKBX24PUONK7x3tk8Xbmi0m6TIqRbP-m_nx6-GFq7rLKLPToI6fPLIdfe6DJ3ujaF32NcAQc-pT-Gc2qo</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>SURJEET POHAR</creator><creator>DEMETZ, C</creator><creator>POPPEMA, S</creator><creator>HUGH, J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>Chronic lymphocytic leukemia with CNS involvement</title><author>SURJEET POHAR ; DEMETZ, C ; POPPEMA, S ; HUGH, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-4bfc7ad4669b54c794c77f637cc380961e5474100ce399ca1bd33948a8fcb0363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukemic Infiltration</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SURJEET POHAR</creatorcontrib><creatorcontrib>DEMETZ, C</creatorcontrib><creatorcontrib>POPPEMA, S</creatorcontrib><creatorcontrib>HUGH, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SURJEET POHAR</au><au>DEMETZ, C</au><au>POPPEMA, S</au><au>HUGH, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic lymphocytic leukemia with CNS involvement</atitle><jtitle>Journal of neuro-oncology</jtitle><addtitle>J Neurooncol</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>16</volume><issue>1</issue><spage>35</spage><epage>37</epage><pages>35-37</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><coden>JNODD2</coden><abstract>Direct involvement of the brain by chronic lymphocytic leukemia (CLL) is extremely rare. This is the second documented case. A 63 year-old-man presented with motor deficits. Conventional radiographic imaging showed no abnormalities but an MRI scan of the head showed a high signal intensity lesion in the left cerebellum. Biopsy of this area showed a perivascular infiltrate of small B lymphocytes consistent with CLL involvement. The patient was treated with radiotherapy and had some improvement in symptoms. Three years later he remains alive with some neurologic deficit. This case confirms that CLL can be complicated by direct brain involvement.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>8410140</pmid><doi>10.1007/BF01324832</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-594X |
| ispartof | Journal of neuro-oncology, 1993-04, Vol.16 (1), p.35-37 |
| issn | 0167-594X 1573-7373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76001791 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Biological and medical sciences Brain - pathology Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukemic Infiltration Magnetic Resonance Imaging Male Medical sciences Middle Aged |
| title | Chronic lymphocytic leukemia with CNS involvement |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A42%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20lymphocytic%20leukemia%20with%20CNS%20involvement&rft.jtitle=Journal%20of%20neuro-oncology&rft.au=SURJEET%20POHAR&rft.date=1993-04-01&rft.volume=16&rft.issue=1&rft.spage=35&rft.epage=37&rft.pages=35-37&rft.issn=0167-594X&rft.eissn=1573-7373&rft.coden=JNODD2&rft_id=info:doi/10.1007/BF01324832&rft_dat=%3Cproquest_cross%3E76001791%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76001791&rft_id=info:pmid/8410140&rfr_iscdi=true |