Nodal and terminal sprouting by regenerating nerve in vitamin E-deficient rats
The increased number of polyinnervated cells in normal and reinnervated extensor digitorum longus (edl) muscle of vitamin E-deficient rats suggests enhanced sprouting by motor neurons in conditions of decreased protection against lipid peroxidation. End-plates and terminal axons were observed by a c...
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| Veröffentlicht in: | Journal of the neurological sciences 1993-07, Vol.117 (1), p.61-67 |
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| container_title | Journal of the neurological sciences |
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| creator | Cuppini, Riccardo Cecchini, Tiziana Ciaroni, Sandra Ambrogini, Patrizia Grande, Paolo Del |
| description | The increased number of polyinnervated cells in normal and reinnervated extensor digitorum longus (edl) muscle of vitamin E-deficient rats suggests enhanced sprouting by motor neurons in conditions of decreased protection against lipid peroxidation. End-plates and terminal axons were observed by a combined technique that shows both end-plate acetylcholinesterase area and axons. Quantitative observations of nodal and terminal sprouting in normally innervated and reinnervated edl muscles of vitamin E-deficient rats were carried out. Branch points of nerve terminal within end-plates were also observed. Three main results were obtained. First, a notable increase of both terminal and nodal sprouting was found in reinnervated muscles of normal and vitamin E-deficient rats; moreover, a relative increase in the number of nodal sprouts occurs in the long run. Second, in muscles of uninjured, vitamin E-deficient rats, nodal and terminal sprouting and branching within end-plate was greater than in controls. Third, nodal sprouting by regenerating axons was more affected by vitamin E-deficiency than terminal sprouting and branching within end-plates. |
| doi_str_mv | 10.1016/0022-510X(93)90155-R |
| format | Article |
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End-plates and terminal axons were observed by a combined technique that shows both end-plate acetylcholinesterase area and axons. Quantitative observations of nodal and terminal sprouting in normally innervated and reinnervated edl muscles of vitamin E-deficient rats were carried out. Branch points of nerve terminal within end-plates were also observed. Three main results were obtained. First, a notable increase of both terminal and nodal sprouting was found in reinnervated muscles of normal and vitamin E-deficient rats; moreover, a relative increase in the number of nodal sprouts occurs in the long run. Second, in muscles of uninjured, vitamin E-deficient rats, nodal and terminal sprouting and branching within end-plate was greater than in controls. Third, nodal sprouting by regenerating axons was more affected by vitamin E-deficiency than terminal sprouting and branching within end-plates.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(93)90155-R</identifier><identifier>PMID: 8410068</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acetylcholinesterase - analysis ; Animals ; Axons - ultrastructure ; Biological and medical sciences ; End-plate ; Extensor digitorum longus muscle ; Lipid Peroxidation ; Male ; Medical sciences ; Motor Endplate - enzymology ; Motor Endplate - ultrastructure ; Motor Neurons - physiology ; Muscle reinnervation ; Nerve Crush ; Nerve Regeneration ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Nodal sprouting ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve - injuries ; Sciatic Nerve - physiology ; Terminal sprouting ; Vitamin E ; Vitamin E Deficiency - physiopathology</subject><ispartof>Journal of the neurological sciences, 1993-07, Vol.117 (1), p.61-67</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2e5a55a16ad421b68ee3592b0099e29e5801f49f210a35f6348bf5f6a727f4d03</citedby><cites>FETCH-LOGICAL-c417t-2e5a55a16ad421b68ee3592b0099e29e5801f49f210a35f6348bf5f6a727f4d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022510X9390155R$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4849468$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8410068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cuppini, Riccardo</creatorcontrib><creatorcontrib>Cecchini, Tiziana</creatorcontrib><creatorcontrib>Ciaroni, Sandra</creatorcontrib><creatorcontrib>Ambrogini, Patrizia</creatorcontrib><creatorcontrib>Grande, Paolo Del</creatorcontrib><title>Nodal and terminal sprouting by regenerating nerve in vitamin E-deficient rats</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>The increased number of polyinnervated cells in normal and reinnervated extensor digitorum longus (edl) muscle of vitamin E-deficient rats suggests enhanced sprouting by motor neurons in conditions of decreased protection against lipid peroxidation. End-plates and terminal axons were observed by a combined technique that shows both end-plate acetylcholinesterase area and axons. Quantitative observations of nodal and terminal sprouting in normally innervated and reinnervated edl muscles of vitamin E-deficient rats were carried out. Branch points of nerve terminal within end-plates were also observed. Three main results were obtained. First, a notable increase of both terminal and nodal sprouting was found in reinnervated muscles of normal and vitamin E-deficient rats; moreover, a relative increase in the number of nodal sprouts occurs in the long run. Second, in muscles of uninjured, vitamin E-deficient rats, nodal and terminal sprouting and branching within end-plate was greater than in controls. Third, nodal sprouting by regenerating axons was more affected by vitamin E-deficiency than terminal sprouting and branching within end-plates.</description><subject>Acetylcholinesterase - analysis</subject><subject>Animals</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>End-plate</subject><subject>Extensor digitorum longus muscle</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Endplate - enzymology</subject><subject>Motor Endplate - ultrastructure</subject><subject>Motor Neurons - physiology</subject><subject>Muscle reinnervation</subject><subject>Nerve Crush</subject><subject>Nerve Regeneration</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Nodal sprouting</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic Nerve - physiology</subject><subject>Terminal sprouting</subject><subject>Vitamin E</subject><subject>Vitamin E Deficiency - physiopathology</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78A4UeRPRQnbRJmlwEkfUDREEUvIW0nUik22rSLuy_N91d9qinmeF9ZhgeQo4pXFKg4gogy1JO4eNc5RcKKOfp6xaZUFnIlEuZb5PJBtkj-yF8AYCQUu2SXcno2E_I83NXmyYxbZ306GeujUP49t3Qu_YzKReJx09s0ZvlHJs5Jq5N5q43EU6maY3WVQ7bPolMOCQ71jQBj9b1gLzfTd9uH9Knl_vH25untGK06NMMueHcUGFqltFSSMScq6wEUAozhVwCtUzZjILJuRU5k6WN1RRZYVkN-QE5W92Nr_4MGHo9c6HCpjEtdkPQhQCgTBX_glQIlUMhIshWYOW7EDxa_e3dzPiFpqBH33qUqUeZWuV66Vu_xrWT9f2hnGG9WVoLjvnpOjehMo31pq1c2GBMMsWW2PUKwyht7tDrMEqtsHYeq17Xnfv7j1-BjZtx</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Cuppini, Riccardo</creator><creator>Cecchini, Tiziana</creator><creator>Ciaroni, Sandra</creator><creator>Ambrogini, Patrizia</creator><creator>Grande, Paolo Del</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930701</creationdate><title>Nodal and terminal sprouting by regenerating nerve in vitamin E-deficient rats</title><author>Cuppini, Riccardo ; Cecchini, Tiziana ; Ciaroni, Sandra ; Ambrogini, Patrizia ; Grande, Paolo Del</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2e5a55a16ad421b68ee3592b0099e29e5801f49f210a35f6348bf5f6a727f4d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acetylcholinesterase - analysis</topic><topic>Animals</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>End-plate</topic><topic>Extensor digitorum longus muscle</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Endplate - enzymology</topic><topic>Motor Endplate - ultrastructure</topic><topic>Motor Neurons - physiology</topic><topic>Muscle reinnervation</topic><topic>Nerve Crush</topic><topic>Nerve Regeneration</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Nodal sprouting</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sciatic Nerve - injuries</topic><topic>Sciatic Nerve - physiology</topic><topic>Terminal sprouting</topic><topic>Vitamin E</topic><topic>Vitamin E Deficiency - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cuppini, Riccardo</creatorcontrib><creatorcontrib>Cecchini, Tiziana</creatorcontrib><creatorcontrib>Ciaroni, Sandra</creatorcontrib><creatorcontrib>Ambrogini, Patrizia</creatorcontrib><creatorcontrib>Grande, Paolo Del</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cuppini, Riccardo</au><au>Cecchini, Tiziana</au><au>Ciaroni, Sandra</au><au>Ambrogini, Patrizia</au><au>Grande, Paolo Del</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nodal and terminal sprouting by regenerating nerve in vitamin E-deficient rats</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>117</volume><issue>1</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>The increased number of polyinnervated cells in normal and reinnervated extensor digitorum longus (edl) muscle of vitamin E-deficient rats suggests enhanced sprouting by motor neurons in conditions of decreased protection against lipid peroxidation. End-plates and terminal axons were observed by a combined technique that shows both end-plate acetylcholinesterase area and axons. Quantitative observations of nodal and terminal sprouting in normally innervated and reinnervated edl muscles of vitamin E-deficient rats were carried out. Branch points of nerve terminal within end-plates were also observed. Three main results were obtained. First, a notable increase of both terminal and nodal sprouting was found in reinnervated muscles of normal and vitamin E-deficient rats; moreover, a relative increase in the number of nodal sprouts occurs in the long run. Second, in muscles of uninjured, vitamin E-deficient rats, nodal and terminal sprouting and branching within end-plate was greater than in controls. Third, nodal sprouting by regenerating axons was more affected by vitamin E-deficiency than terminal sprouting and branching within end-plates.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>8410068</pmid><doi>10.1016/0022-510X(93)90155-R</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1993-07, Vol.117 (1), p.61-67 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholinesterase - analysis Animals Axons - ultrastructure Biological and medical sciences End-plate Extensor digitorum longus muscle Lipid Peroxidation Male Medical sciences Motor Endplate - enzymology Motor Endplate - ultrastructure Motor Neurons - physiology Muscle reinnervation Nerve Crush Nerve Regeneration Nervous system involvement in other diseases. Miscellaneous Neurology Nodal sprouting Rats Rats, Sprague-Dawley Sciatic Nerve - injuries Sciatic Nerve - physiology Terminal sprouting Vitamin E Vitamin E Deficiency - physiopathology |
| title | Nodal and terminal sprouting by regenerating nerve in vitamin E-deficient rats |
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