Depletion and Repopulation of Epidermal Dendritic Cells After Allogeneic Bone Marrow Transplantation in Humans
We have observed marked depletion of epidermal dendritic cells, defined by monoclonal antibodies directed against HLA-DR (Ia-like) and T6 antigens, after allogeneic bone marrow transplantation. To more precisely characterize this observation, we examined a total of 39 sequential biopsies from 15 pat...
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| Veröffentlicht in: | Journal of investigative dermatology 1985-03, Vol.84 (3), p.210-214 |
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| container_title | Journal of investigative dermatology |
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| creator | Murphy, George F Merot, Yves Tong, Arthur K.F. Smith, Brian Mihm, Martin C |
| description | We have observed marked depletion of epidermal dendritic cells, defined by monoclonal antibodies directed against HLA-DR (Ia-like) and T6 antigens, after allogeneic bone marrow transplantation. To more precisely characterize this observation, we examined a total of 39 sequential biopsies from 15 patients both before and after allogeneic bone marrow transplantation. Profound depletion of HLA-DR and T6-positive epidermal dendritic cells was observed early after transplantation (1–4 weeks), followed by gradual and variable repopulation. Transmission electron microscopy confirmed absence of dendritic cells in selected biopsies. Depletion of dendritic cells did not appear to be related to development of clinical or histologic evidence of graft-versus-host disease, suggesting that depletion may relate to pretransplant conditioning regimens. The rate of return of these cells, however, may be influenced by the presence or persistence of clinical disease. Repopulation of epidermal dendritic cells after initial depletion in bone marrow transplantation represents a human model relevant to studies concerned with the origin and kinetics of Langerhans cells. |
| doi_str_mv | 10.1111/1523-1747.ep12265149 |
| format | Article |
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To more precisely characterize this observation, we examined a total of 39 sequential biopsies from 15 patients both before and after allogeneic bone marrow transplantation. Profound depletion of HLA-DR and T6-positive epidermal dendritic cells was observed early after transplantation (1–4 weeks), followed by gradual and variable repopulation. Transmission electron microscopy confirmed absence of dendritic cells in selected biopsies. Depletion of dendritic cells did not appear to be related to development of clinical or histologic evidence of graft-versus-host disease, suggesting that depletion may relate to pretransplant conditioning regimens. The rate of return of these cells, however, may be influenced by the presence or persistence of clinical disease. Repopulation of epidermal dendritic cells after initial depletion in bone marrow transplantation represents a human model relevant to studies concerned with the origin and kinetics of Langerhans cells.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12265149</identifier><identifier>PMID: 3919109</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibodies, Monoclonal - immunology ; Antigens, Differentiation, T-Lymphocyte ; Antigens, Surface - immunology ; Biological and medical sciences ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Child, Preschool ; Epidermal Cells ; Epidermis - immunology ; Epidermis - pathology ; Female ; Graft vs Host Disease - immunology ; Graft vs Host Disease - pathology ; Histocompatibility Antigens Class II - immunology ; Humans ; Immunoenzyme Techniques ; Infant ; Langerhans Cells - immunology ; Male ; Medical sciences ; Microscopy, Electron ; Transfusions. Complications. Transfusion reactions. 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To more precisely characterize this observation, we examined a total of 39 sequential biopsies from 15 patients both before and after allogeneic bone marrow transplantation. Profound depletion of HLA-DR and T6-positive epidermal dendritic cells was observed early after transplantation (1–4 weeks), followed by gradual and variable repopulation. Transmission electron microscopy confirmed absence of dendritic cells in selected biopsies. Depletion of dendritic cells did not appear to be related to development of clinical or histologic evidence of graft-versus-host disease, suggesting that depletion may relate to pretransplant conditioning regimens. The rate of return of these cells, however, may be influenced by the presence or persistence of clinical disease. Repopulation of epidermal dendritic cells after initial depletion in bone marrow transplantation represents a human model relevant to studies concerned with the origin and kinetics of Langerhans cells.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, Differentiation, T-Lymphocyte</subject><subject>Antigens, Surface - immunology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Child, Preschool</subject><subject>Epidermal Cells</subject><subject>Epidermis - immunology</subject><subject>Epidermis - pathology</subject><subject>Female</subject><subject>Graft vs Host Disease - immunology</subject><subject>Graft vs Host Disease - pathology</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Infant</subject><subject>Langerhans Cells - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Transfusions. Complications. Transfusion reactions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, Differentiation, T-Lymphocyte</topic><topic>Antigens, Surface - immunology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Child, Preschool</topic><topic>Epidermal Cells</topic><topic>Epidermis - immunology</topic><topic>Epidermis - pathology</topic><topic>Female</topic><topic>Graft vs Host Disease - immunology</topic><topic>Graft vs Host Disease - pathology</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Infant</topic><topic>Langerhans Cells - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murphy, George F</creatorcontrib><creatorcontrib>Merot, Yves</creatorcontrib><creatorcontrib>Tong, Arthur K.F.</creatorcontrib><creatorcontrib>Smith, Brian</creatorcontrib><creatorcontrib>Mihm, Martin C</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murphy, George F</au><au>Merot, Yves</au><au>Tong, Arthur K.F.</au><au>Smith, Brian</au><au>Mihm, Martin C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depletion and Repopulation of Epidermal Dendritic Cells After Allogeneic Bone Marrow Transplantation in Humans</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1985-03</date><risdate>1985</risdate><volume>84</volume><issue>3</issue><spage>210</spage><epage>214</epage><pages>210-214</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>We have observed marked depletion of epidermal dendritic cells, defined by monoclonal antibodies directed against HLA-DR (Ia-like) and T6 antigens, after allogeneic bone marrow transplantation. To more precisely characterize this observation, we examined a total of 39 sequential biopsies from 15 patients both before and after allogeneic bone marrow transplantation. Profound depletion of HLA-DR and T6-positive epidermal dendritic cells was observed early after transplantation (1–4 weeks), followed by gradual and variable repopulation. Transmission electron microscopy confirmed absence of dendritic cells in selected biopsies. Depletion of dendritic cells did not appear to be related to development of clinical or histologic evidence of graft-versus-host disease, suggesting that depletion may relate to pretransplant conditioning regimens. The rate of return of these cells, however, may be influenced by the presence or persistence of clinical disease. Repopulation of epidermal dendritic cells after initial depletion in bone marrow transplantation represents a human model relevant to studies concerned with the origin and kinetics of Langerhans cells.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>3919109</pmid><doi>10.1111/1523-1747.ep12265149</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies, Monoclonal - immunology Antigens, Differentiation, T-Lymphocyte Antigens, Surface - immunology Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Child, Preschool Epidermal Cells Epidermis - immunology Epidermis - pathology Female Graft vs Host Disease - immunology Graft vs Host Disease - pathology Histocompatibility Antigens Class II - immunology Humans Immunoenzyme Techniques Infant Langerhans Cells - immunology Male Medical sciences Microscopy, Electron Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Depletion and Repopulation of Epidermal Dendritic Cells After Allogeneic Bone Marrow Transplantation in Humans |
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