Effect of protein intake on glycaemic control and renal function in type 2 (non-insulin-dependent) diabetes mellitus
Recent clinical investigations have suggested that dietary protein intake may modulate the progression of diabetic nephropathy and influence glycaemic control in Type 2 (non-insulin-dependent) diabetes mellitus. Twelve normotensive Type 2 diabetic patients with microalbuminuria took part in a random...
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| Veröffentlicht in: | Diabetologia 1993-09, Vol.36 (9), p.829-834 |
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| creator | POMERLEAU, J VERDY, M GARREL, D. R NADEAU, M. H |
| description | Recent clinical investigations have suggested that dietary protein intake may modulate the progression of diabetic nephropathy and influence glycaemic control in Type 2 (non-insulin-dependent) diabetes mellitus. Twelve normotensive Type 2 diabetic patients with microalbuminuria took part in a randomized cross-over trial of a 3-week high protein diet (2.0 g/kg.desirable weight per day) and a 3-week moderate protein diet (0.8 g/kg desirable weight per day) to test the simultaneous effect of protein intake modulation on glycaemic control and renal function. Both diets were isoenergetic and the moderate protein diet was supplemented with calcium and phosphate. Renal function and glycaemic control were evaluated at the beginning and at the end of each diet. The moderate protein diet reduced the urinary albumin excretion rate, glomerular filtration rate, creatinine clearance, and proteinuria without adversely affecting glycaemic control; fasting glycaemia and the ratio of fructosamine to proteins were significantly reduced. The high protein diet induced similar improvements in glycaemic control but small changes in renal function. |
| doi_str_mv | 10.1007/BF00400358 |
| format | Article |
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The moderate protein diet reduced the urinary albumin excretion rate, glomerular filtration rate, creatinine clearance, and proteinuria without adversely affecting glycaemic control; fasting glycaemia and the ratio of fructosamine to proteins were significantly reduced. The high protein diet induced similar improvements in glycaemic control but small changes in renal function.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/BF00400358</identifier><identifier>PMID: 8405754</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Albuminuria ; Biological and medical sciences ; Blood Glucose - metabolism ; Creatinine - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diet, Diabetic ; Dietary Proteins ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. 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R</creatorcontrib><creatorcontrib>NADEAU, M. H</creatorcontrib><title>Effect of protein intake on glycaemic control and renal function in type 2 (non-insulin-dependent) diabetes mellitus</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>Recent clinical investigations have suggested that dietary protein intake may modulate the progression of diabetic nephropathy and influence glycaemic control in Type 2 (non-insulin-dependent) diabetes mellitus. Twelve normotensive Type 2 diabetic patients with microalbuminuria took part in a randomized cross-over trial of a 3-week high protein diet (2.0 g/kg.desirable weight per day) and a 3-week moderate protein diet (0.8 g/kg desirable weight per day) to test the simultaneous effect of protein intake modulation on glycaemic control and renal function. Both diets were isoenergetic and the moderate protein diet was supplemented with calcium and phosphate. Renal function and glycaemic control were evaluated at the beginning and at the end of each diet. The moderate protein diet reduced the urinary albumin excretion rate, glomerular filtration rate, creatinine clearance, and proteinuria without adversely affecting glycaemic control; fasting glycaemia and the ratio of fructosamine to proteins were significantly reduced. The high protein diet induced similar improvements in glycaemic control but small changes in renal function.</description><subject>Albuminuria</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Creatinine - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet, Diabetic</subject><subject>Dietary Proteins</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Glomerular Filtration Rate</subject><subject>Glucagon - blood</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Kidney - physiopathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Proteinuria</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxDAUhYMo4_jYuBeyEFGhmjRpmi518AUDbhTcldv0RqJtMjbpYv69HRx0dRbn43DvR8gJZ9ecsfLm7oExyZgo9A6ZcynyjMlc75I5YzzPuFbv--Qgxk-2YaSakZmWrCgLOSfp3lo0iQZLV0NI6Dx1PsEX0uDpR7c2gL0z1ASfhtBR8C0d0ENH7ehNcmGD07ReIc3phQ8-cz6OnfNZiyv0Lfp0SVsHDSaMtMeuc2mMR2TPQhfxeJuH5O3h_nXxlC1fHp8Xt8vM5CrXGVSodaWsaEBw2xhUU_KiAFANZ9CIMrcFB6uwaqwFLpWSDHNQoK1ssRSH5Px3d3rte8SY6t5FMx0BHsMY67KoKiVLNoFXv6AZQowD2no1uB6Gdc1ZvVFc_yue4NPt6tj02P6hW6dTf7btIRro7ADeuPiHSS0LIbj4ATMYhB0</recordid><startdate>199309</startdate><enddate>199309</enddate><creator>POMERLEAU, J</creator><creator>VERDY, M</creator><creator>GARREL, D. 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H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2628-a9e8896f3ba31fbce6a31155aa6b10ab372f51af6e9bffa146640e2a6a8f4de73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Albuminuria</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Creatinine - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet, Diabetic</topic><topic>Dietary Proteins</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Glomerular Filtration Rate</topic><topic>Glucagon - blood</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Kidney - physiopathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Proteinuria</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>POMERLEAU, J</creatorcontrib><creatorcontrib>VERDY, M</creatorcontrib><creatorcontrib>GARREL, D. R</creatorcontrib><creatorcontrib>NADEAU, M. 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H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of protein intake on glycaemic control and renal function in type 2 (non-insulin-dependent) diabetes mellitus</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>1993-09</date><risdate>1993</risdate><volume>36</volume><issue>9</issue><spage>829</spage><epage>834</epage><pages>829-834</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Recent clinical investigations have suggested that dietary protein intake may modulate the progression of diabetic nephropathy and influence glycaemic control in Type 2 (non-insulin-dependent) diabetes mellitus. Twelve normotensive Type 2 diabetic patients with microalbuminuria took part in a randomized cross-over trial of a 3-week high protein diet (2.0 g/kg.desirable weight per day) and a 3-week moderate protein diet (0.8 g/kg desirable weight per day) to test the simultaneous effect of protein intake modulation on glycaemic control and renal function. Both diets were isoenergetic and the moderate protein diet was supplemented with calcium and phosphate. Renal function and glycaemic control were evaluated at the beginning and at the end of each diet. The moderate protein diet reduced the urinary albumin excretion rate, glomerular filtration rate, creatinine clearance, and proteinuria without adversely affecting glycaemic control; fasting glycaemia and the ratio of fructosamine to proteins were significantly reduced. The high protein diet induced similar improvements in glycaemic control but small changes in renal function.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>8405754</pmid><doi>10.1007/BF00400358</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetologia, 1993-09, Vol.36 (9), p.829-834 |
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| language | eng |
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| subjects | Albuminuria Biological and medical sciences Blood Glucose - metabolism Creatinine - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diet, Diabetic Dietary Proteins Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glomerular Filtration Rate Glucagon - blood Humans Insulin - blood Kidney - physiopathology Medical sciences Middle Aged Proteinuria |
| title | Effect of protein intake on glycaemic control and renal function in type 2 (non-insulin-dependent) diabetes mellitus |
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