The relationship between follicle-stimulating hormone dose and level and its relevance for ovulation induction with adjuvant gonadotropin-releasing hormone-agonist treatment
To investigate the effect of a GnRH agonist (GnRH-a) on the FSH threshold level and the relationship between the FSH dose and the FSH level of patients suffering from polycystic ovarian syndrome (PCOS). The stimulation with low-dose FSH in PCOS (group 1) was compared with the subsequently performed...
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| Veröffentlicht in: | Fertility and sterility 1993-10, Vol.60 (4), p.620-625 |
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| container_title | Fertility and sterility |
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| creator | Scheele, Fedde Hompes, Peter G.A. van der Meer, Maartje Schoute, Erik Schoemaker, Joop |
| description | To investigate the effect of a GnRH agonist (GnRH-a) on the FSH threshold level and the relationship between the FSH dose and the FSH level of patients suffering from polycystic ovarian syndrome (PCOS).
The stimulation with low-dose FSH in PCOS (group 1) was compared with the subsequently performed stimulation with low-dose FSH combined with GnRH-a in another group of patients suffering from the same syndrome (group 2).
Specialist Reproductive Endocrine Unit.
Suffering from clomiphene citrate-resistant PCOS.
The FSH threshold level for ongoing follicular growth and the relationship between dose and level of FSH.
In 15 patients in group 1 and in 13 patients in group 2, respectively, 39 and 32 stimulation cycles were performed. Below and above threshold values of FSH of group 1 and 2 did not differ significantly. For the equation stable level of FSH (Y mIU/mL) = A X infusion rate of FSH (X IU/24 h) + basal level of FSH (B mIU/mL), the median A of group 1 was 0.027 and A of group 2 was 0.055 (significant difference).
In PCOS, a change of the FSH threshold level for ongoing follicular growth induced by the GnRH-a could neither be proven nor ruled out. The use of a GnRH-a resulted in larger FSH level increases per IU/24 h of FSH administered and might therefore interfere with the effect of low-dose FSH treatment. |
| doi_str_mv | 10.1016/S0015-0282(16)56211-6 |
| format | Article |
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The stimulation with low-dose FSH in PCOS (group 1) was compared with the subsequently performed stimulation with low-dose FSH combined with GnRH-a in another group of patients suffering from the same syndrome (group 2).
Specialist Reproductive Endocrine Unit.
Suffering from clomiphene citrate-resistant PCOS.
The FSH threshold level for ongoing follicular growth and the relationship between dose and level of FSH.
In 15 patients in group 1 and in 13 patients in group 2, respectively, 39 and 32 stimulation cycles were performed. Below and above threshold values of FSH of group 1 and 2 did not differ significantly. For the equation stable level of FSH (Y mIU/mL) = A X infusion rate of FSH (X IU/24 h) + basal level of FSH (B mIU/mL), the median A of group 1 was 0.027 and A of group 2 was 0.055 (significant difference).
In PCOS, a change of the FSH threshold level for ongoing follicular growth induced by the GnRH-a could neither be proven nor ruled out. The use of a GnRH-a resulted in larger FSH level increases per IU/24 h of FSH administered and might therefore interfere with the effect of low-dose FSH treatment.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)56211-6</identifier><identifier>PMID: 8405514</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adjuvants, Pharmaceutic - therapeutic use ; Adult ; Biological and medical sciences ; Buserelin - therapeutic use ; Differential Threshold ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Follicle Stimulating Hormone - blood ; Follicle Stimulating Hormone - therapeutic use ; FSH ; GnRH-a ; Hormones. Endocrine system ; Humans ; low dose ; Luteinizing Hormone - blood ; Mathematics ; Medical sciences ; Ovarian Follicle - growth & development ; Ovulation Detection ; ovulation induction ; Pharmacology. Drug treatments ; Polycystic ovary ; Polycystic Ovary Syndrome - drug therapy ; threshold level</subject><ispartof>Fertility and sterility, 1993-10, Vol.60 (4), p.620-625</ispartof><rights>1993 American Society for Reproductive Medicine</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-92a5399b9a7f7957bf5b7b0fafebbaf96e95f4fce717bfbf737c86f30f6b55513</citedby><cites>FETCH-LOGICAL-c389t-92a5399b9a7f7957bf5b7b0fafebbaf96e95f4fce717bfbf737c86f30f6b55513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028216562116$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3758063$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8405514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scheele, Fedde</creatorcontrib><creatorcontrib>Hompes, Peter G.A.</creatorcontrib><creatorcontrib>van der Meer, Maartje</creatorcontrib><creatorcontrib>Schoute, Erik</creatorcontrib><creatorcontrib>Schoemaker, Joop</creatorcontrib><title>The relationship between follicle-stimulating hormone dose and level and its relevance for ovulation induction with adjuvant gonadotropin-releasing hormone-agonist treatment</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To investigate the effect of a GnRH agonist (GnRH-a) on the FSH threshold level and the relationship between the FSH dose and the FSH level of patients suffering from polycystic ovarian syndrome (PCOS).
The stimulation with low-dose FSH in PCOS (group 1) was compared with the subsequently performed stimulation with low-dose FSH combined with GnRH-a in another group of patients suffering from the same syndrome (group 2).
Specialist Reproductive Endocrine Unit.
Suffering from clomiphene citrate-resistant PCOS.
The FSH threshold level for ongoing follicular growth and the relationship between dose and level of FSH.
In 15 patients in group 1 and in 13 patients in group 2, respectively, 39 and 32 stimulation cycles were performed. Below and above threshold values of FSH of group 1 and 2 did not differ significantly. For the equation stable level of FSH (Y mIU/mL) = A X infusion rate of FSH (X IU/24 h) + basal level of FSH (B mIU/mL), the median A of group 1 was 0.027 and A of group 2 was 0.055 (significant difference).
In PCOS, a change of the FSH threshold level for ongoing follicular growth induced by the GnRH-a could neither be proven nor ruled out. The use of a GnRH-a resulted in larger FSH level increases per IU/24 h of FSH administered and might therefore interfere with the effect of low-dose FSH treatment.</description><subject>Adjuvants, Pharmaceutic - therapeutic use</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Buserelin - therapeutic use</subject><subject>Differential Threshold</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle Stimulating Hormone - therapeutic use</subject><subject>FSH</subject><subject>GnRH-a</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>low dose</subject><subject>Luteinizing Hormone - blood</subject><subject>Mathematics</subject><subject>Medical sciences</subject><subject>Ovarian Follicle - growth & development</subject><subject>Ovulation Detection</subject><subject>ovulation induction</subject><subject>Pharmacology. Drug treatments</subject><subject>Polycystic ovary</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>threshold level</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhYnRjO3oI0zCwhhdlEJXA8XKTCb-JZO4cFwToC7TTChogeqJD-U7SnV3Ou5cATnfuZecg9AVJe8pofzDD0Io68h6WL-l_B3ja0o7_gStKGO8Y5z1T9HqjDxHL0p5IIRwKtYX6GLYEMboZoX-3G0BZwi6-hTL1u-wgfoIELFLIXgboCvVT_MCxHu8TXlKEfCYCmAdRxxgD-Fw87Usg2Cvo4Xmzjjt5-Nc7OM428Pt0dct1uPD3LCK71PUY6o57XzsFrMu_2zpdNN9qbhm0HWCWF-iZ06HAq9O5yX6-fnT3c3X7vb7l28317ed7QdZO7nWrJfSSC2ckEwYx4wwxGkHxmgnOUjmNs6CoE0zTvTCDtz1xHHDWi79JXpznLvL6dcMparJFwsh6AhpLkowKRvHG8iOoM2plAxO7bKfdP6tKFFLTepQk1o6UO11qEktvqvTgtlMMJ5dp16a_vqk62J1cLmF6ssZ6wUbCO8b9vGIQQtj7yGrYj20_EefwVY1Jv-fj_wFzP61fA</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>Scheele, Fedde</creator><creator>Hompes, Peter G.A.</creator><creator>van der Meer, Maartje</creator><creator>Schoute, Erik</creator><creator>Schoemaker, Joop</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>The relationship between follicle-stimulating hormone dose and level and its relevance for ovulation induction with adjuvant gonadotropin-releasing hormone-agonist treatment</title><author>Scheele, Fedde ; Hompes, Peter G.A. ; van der Meer, Maartje ; Schoute, Erik ; Schoemaker, Joop</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-92a5399b9a7f7957bf5b7b0fafebbaf96e95f4fce717bfbf737c86f30f6b55513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adjuvants, Pharmaceutic - therapeutic use</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Buserelin - therapeutic use</topic><topic>Differential Threshold</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle Stimulating Hormone - therapeutic use</topic><topic>FSH</topic><topic>GnRH-a</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>low dose</topic><topic>Luteinizing Hormone - blood</topic><topic>Mathematics</topic><topic>Medical sciences</topic><topic>Ovarian Follicle - growth & development</topic><topic>Ovulation Detection</topic><topic>ovulation induction</topic><topic>Pharmacology. Drug treatments</topic><topic>Polycystic ovary</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>threshold level</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scheele, Fedde</creatorcontrib><creatorcontrib>Hompes, Peter G.A.</creatorcontrib><creatorcontrib>van der Meer, Maartje</creatorcontrib><creatorcontrib>Schoute, Erik</creatorcontrib><creatorcontrib>Schoemaker, Joop</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scheele, Fedde</au><au>Hompes, Peter G.A.</au><au>van der Meer, Maartje</au><au>Schoute, Erik</au><au>Schoemaker, Joop</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between follicle-stimulating hormone dose and level and its relevance for ovulation induction with adjuvant gonadotropin-releasing hormone-agonist treatment</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>60</volume><issue>4</issue><spage>620</spage><epage>625</epage><pages>620-625</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To investigate the effect of a GnRH agonist (GnRH-a) on the FSH threshold level and the relationship between the FSH dose and the FSH level of patients suffering from polycystic ovarian syndrome (PCOS).
The stimulation with low-dose FSH in PCOS (group 1) was compared with the subsequently performed stimulation with low-dose FSH combined with GnRH-a in another group of patients suffering from the same syndrome (group 2).
Specialist Reproductive Endocrine Unit.
Suffering from clomiphene citrate-resistant PCOS.
The FSH threshold level for ongoing follicular growth and the relationship between dose and level of FSH.
In 15 patients in group 1 and in 13 patients in group 2, respectively, 39 and 32 stimulation cycles were performed. Below and above threshold values of FSH of group 1 and 2 did not differ significantly. For the equation stable level of FSH (Y mIU/mL) = A X infusion rate of FSH (X IU/24 h) + basal level of FSH (B mIU/mL), the median A of group 1 was 0.027 and A of group 2 was 0.055 (significant difference).
In PCOS, a change of the FSH threshold level for ongoing follicular growth induced by the GnRH-a could neither be proven nor ruled out. The use of a GnRH-a resulted in larger FSH level increases per IU/24 h of FSH administered and might therefore interfere with the effect of low-dose FSH treatment.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8405514</pmid><doi>10.1016/S0015-0282(16)56211-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 1993-10, Vol.60 (4), p.620-625 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75995516 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adjuvants, Pharmaceutic - therapeutic use Adult Biological and medical sciences Buserelin - therapeutic use Differential Threshold Dose-Response Relationship, Drug Drug Therapy, Combination Female Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - therapeutic use FSH GnRH-a Hormones. Endocrine system Humans low dose Luteinizing Hormone - blood Mathematics Medical sciences Ovarian Follicle - growth & development Ovulation Detection ovulation induction Pharmacology. Drug treatments Polycystic ovary Polycystic Ovary Syndrome - drug therapy threshold level |
| title | The relationship between follicle-stimulating hormone dose and level and its relevance for ovulation induction with adjuvant gonadotropin-releasing hormone-agonist treatment |
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