In utero acute graft-versus-host disease in a neonate with severe combined immunodeficiency
We describe a male neonate with severe combined immunodeficiency who at birth had acute graft-versus-host disease (GVHD) as a result of maternal-fetal transfusion during pregnancy. Several clinical signs helped establish this diagnosis. Findings of a skin biopsy specimen confirmed the diagnosis of a...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1993-11, Vol.29 (5), p.862-865 |
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| container_end_page | 865 |
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| container_issue | 5 |
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| container_title | Journal of the American Academy of Dermatology |
| container_volume | 29 |
| creator | Alain, Guylaine Carrier, Charles Beaumier, Louis Bernard, Jean Lemay, Martin Lavoie, Aubert |
| description | We describe a male neonate with severe combined immunodeficiency who at birth had acute graft-versus-host disease (GVHD) as a result of maternal-fetal transfusion during pregnancy. Several clinical signs helped establish this diagnosis. Findings of a skin biopsy specimen confirmed the diagnosis of acute GVHD. Immunologic evaluation disclosed an absence of T and B lymphocytes. Acute GVHD in severe combined immunodeficiency most often occurs during the first weeks of life; intrauterine occurrence is unusual. |
| doi_str_mv | 10.1016/0190-9622(93)70257-T |
| format | Article |
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Several clinical signs helped establish this diagnosis. Findings of a skin biopsy specimen confirmed the diagnosis of acute GVHD. Immunologic evaluation disclosed an absence of T and B lymphocytes. Acute GVHD in severe combined immunodeficiency most often occurs during the first weeks of life; intrauterine occurrence is unusual.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Dermatitis, Exfoliative - etiology</subject><subject>Female</subject><subject>Fetomaternal Transfusion - complications</subject><subject>Graft vs Host Disease - etiology</subject><subject>Graft vs Host Disease - pathology</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Severe Combined Immunodeficiency - complications</subject><subject>Severe Combined Immunodeficiency - congenital</subject><subject>Skin - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1vFDEQhi0ECpfAPwiSC4SSYom93vVHg4SiJESKRHOpKCx_jBOj293g2Q3Kv8eXO11JNcX7zOidh5BTzr5yxuUF44Y1RrbtmRHnirW9atZvyIozoxqptHpLVgfkPTlG_M0YM51QR-RId0zrVq_Ir9uRLjOUibpQJ30oLs3NMxRcsHmccKYxIzgEmkfq6AjT6Cr2N8-PFKFyQMM0-DxCpHkYlnGKkHLIMIaXD-RdchuEj_t5Qu6vr9aXP5q7nze3l9_vmiC0nJvWm9i7JHzLWwaGQ3J94j0XKnYpyiAE6-p3IL2MPnamPthK3_k-RROU9OKEfNndfSrTnwVwtkPGAJuNq3UXtKo3phdaV7DbgaFMiAWSfSp5cOXFcma3Tu1WmN0Ks0bYV6d2Xdc-7e8vfoB4WNpLrPnnfe4wuE0qbgwZD5hQulNMVezbDoPq4jlDsfjqCWIuEGYbp_z_Hv8AjqaTwg</recordid><startdate>19931101</startdate><enddate>19931101</enddate><creator>Alain, Guylaine</creator><creator>Carrier, Charles</creator><creator>Beaumier, Louis</creator><creator>Bernard, Jean</creator><creator>Lemay, Martin</creator><creator>Lavoie, Aubert</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931101</creationdate><title>In utero acute graft-versus-host disease in a neonate with severe combined immunodeficiency</title><author>Alain, Guylaine ; Carrier, Charles ; Beaumier, Louis ; Bernard, Jean ; Lemay, Martin ; Lavoie, Aubert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2b9d5af3b2120e91efa5f15137d4fd6c3304025e6b6dbd4910926b4b5fd9c76b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Dermatitis, Exfoliative - etiology</topic><topic>Female</topic><topic>Fetomaternal Transfusion - complications</topic><topic>Graft vs Host Disease - etiology</topic><topic>Graft vs Host Disease - pathology</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Severe Combined Immunodeficiency - complications</topic><topic>Severe Combined Immunodeficiency - congenital</topic><topic>Skin - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alain, Guylaine</creatorcontrib><creatorcontrib>Carrier, Charles</creatorcontrib><creatorcontrib>Beaumier, Louis</creatorcontrib><creatorcontrib>Bernard, Jean</creatorcontrib><creatorcontrib>Lemay, Martin</creatorcontrib><creatorcontrib>Lavoie, Aubert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alain, Guylaine</au><au>Carrier, Charles</au><au>Beaumier, Louis</au><au>Bernard, Jean</au><au>Lemay, Martin</au><au>Lavoie, Aubert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In utero acute graft-versus-host disease in a neonate with severe combined immunodeficiency</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>29</volume><issue>5</issue><spage>862</spage><epage>865</epage><pages>862-865</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>We describe a male neonate with severe combined immunodeficiency who at birth had acute graft-versus-host disease (GVHD) as a result of maternal-fetal transfusion during pregnancy. 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| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 1993-11, Vol.29 (5), p.862-865 |
| issn | 0190-9622 1097-6787 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biopsy Dermatitis, Exfoliative - etiology Female Fetomaternal Transfusion - complications Graft vs Host Disease - etiology Graft vs Host Disease - pathology Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant, Newborn Male Medical sciences Pregnancy Severe Combined Immunodeficiency - complications Severe Combined Immunodeficiency - congenital Skin - pathology |
| title | In utero acute graft-versus-host disease in a neonate with severe combined immunodeficiency |
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