Primary acquired melanosis of the conjunctiva
Forty-one cases of conjunctival primary acquired melanosis (PAM) were studied to determine the frequency of progression to malignant melanoma and to establish prognostic parameters for progression to melanoma. Two subdivisions were identified: lesions with cytologically atypical melanocytes (PAM wit...
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| Veröffentlicht in: | Human pathology 1985-02, Vol.16 (2), p.129-135 |
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| creator | Folberg, Robert McLean, Ian W. Zimmerman, Lorenz E. |
| description | Forty-one cases of conjunctival primary acquired melanosis (PAM) were studied to determine the frequency of progression to malignant melanoma and to establish prognostic parameters for progression to melanoma. Two subdivisions were identified: lesions with cytologically atypical melanocytes (PAM with atypia, 28 lesions, 68.3 per cent) and those lacking cytologically atypical melanocytes (PAM without atypia, 13 lesions, 31.7 per cent). None of the lesions of PAM without atypia progressed to melanoma. Thirteen of the 28 lesions of PAM with atypia (46.4 per cent) progressed to melanoma. Progression to melanoma was more frequent in the lesions of PAM with atypia if basilar hyperplasia was not the dominant histologic pattern (90 per cent progression,
P=0.02) or if any epithelioid cells were present (75 per cent progression,
P=0.02). It was not possible to determine which lesions were atypical on the basis of clinical appearance. Lesions at risk for the development of melanoma should be totally extirpated. |
| doi_str_mv | 10.1016/S0046-8177(85)80061-7 |
| format | Article |
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P=0.02) or if any epithelioid cells were present (75 per cent progression,
P=0.02). It was not possible to determine which lesions were atypical on the basis of clinical appearance. Lesions at risk for the development of melanoma should be totally extirpated.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(85)80061-7</identifier><identifier>PMID: 3972395</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biopsy ; Conjunctival Diseases - pathology ; Conjunctival Diseases - surgery ; Conjunctival Neoplasms - etiology ; Epithelium - pathology ; Follow-Up Studies ; Humans ; Hyperplasia ; Medical sciences ; Melanocytes ; Melanoma - etiology ; Melanosis - pathology ; Melanosis - surgery ; Ophthalmology ; Prognosis ; Recurrence ; Risk ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><ispartof>Human pathology, 1985-02, Vol.16 (2), p.129-135</ispartof><rights>1985 W. B. Saunders Co.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-2a165ae0116af67cc151a67652dce4aa5badc47942ddd5be1cfb3138361bd77f3</citedby><cites>FETCH-LOGICAL-c389t-2a165ae0116af67cc151a67652dce4aa5badc47942ddd5be1cfb3138361bd77f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817785800617$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9018127$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3972395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Folberg, Robert</creatorcontrib><creatorcontrib>McLean, Ian W.</creatorcontrib><creatorcontrib>Zimmerman, Lorenz E.</creatorcontrib><title>Primary acquired melanosis of the conjunctiva</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Forty-one cases of conjunctival primary acquired melanosis (PAM) were studied to determine the frequency of progression to malignant melanoma and to establish prognostic parameters for progression to melanoma. Two subdivisions were identified: lesions with cytologically atypical melanocytes (PAM with atypia, 28 lesions, 68.3 per cent) and those lacking cytologically atypical melanocytes (PAM without atypia, 13 lesions, 31.7 per cent). None of the lesions of PAM without atypia progressed to melanoma. Thirteen of the 28 lesions of PAM with atypia (46.4 per cent) progressed to melanoma. Progression to melanoma was more frequent in the lesions of PAM with atypia if basilar hyperplasia was not the dominant histologic pattern (90 per cent progression,
P=0.02) or if any epithelioid cells were present (75 per cent progression,
P=0.02). It was not possible to determine which lesions were atypical on the basis of clinical appearance. Lesions at risk for the development of melanoma should be totally extirpated.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Conjunctival Diseases - pathology</subject><subject>Conjunctival Diseases - surgery</subject><subject>Conjunctival Neoplasms - etiology</subject><subject>Epithelium - pathology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Medical sciences</subject><subject>Melanocytes</subject><subject>Melanoma - etiology</subject><subject>Melanosis - pathology</subject><subject>Melanosis - surgery</subject><subject>Ophthalmology</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Risk</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfoTALEV2M5iST20qkeIOCgroOmSSDKXOpk5mCb--0U7p1dRb_d24fQnPAt4CB331gnPFUghDXkt1IjDmk4ghNgVGSSqrIMZoekFN0FuMKYwCWsQmaUCUIVWyK0vc2VKb9TYz96UPrXVL50tRNDDFpiqT79olt6lVf2y5szDk6KUwZ_cW-ztDX0-Pn4iVdvj2_Lh6WqaVSdSkxwJnxwzZuCi6sBQaGC86Isz4zhuXG2UyojDjnWO7BFjkFKimH3AlR0Bm6Gueu2-an97HTVYjWl8NlvumjFkwpIpUaQDaCtm1ibH2h1-M_GrDeatI7TXrrQEumd5q0GPrm-wV9Xnl36Np7GfLLfW6iNWXRmtqGeMAUBglkO-Z-xPwgYxN8q6MNvrbeDSptp10T_jnkD67vg6U</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Folberg, Robert</creator><creator>McLean, Ian W.</creator><creator>Zimmerman, Lorenz E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Primary acquired melanosis of the conjunctiva</title><author>Folberg, Robert ; McLean, Ian W. ; Zimmerman, Lorenz E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-2a165ae0116af67cc151a67652dce4aa5badc47942ddd5be1cfb3138361bd77f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Conjunctival Diseases - pathology</topic><topic>Conjunctival Diseases - surgery</topic><topic>Conjunctival Neoplasms - etiology</topic><topic>Epithelium - pathology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Medical sciences</topic><topic>Melanocytes</topic><topic>Melanoma - etiology</topic><topic>Melanosis - pathology</topic><topic>Melanosis - surgery</topic><topic>Ophthalmology</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Risk</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Folberg, Robert</creatorcontrib><creatorcontrib>McLean, Ian W.</creatorcontrib><creatorcontrib>Zimmerman, Lorenz E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Folberg, Robert</au><au>McLean, Ian W.</au><au>Zimmerman, Lorenz E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary acquired melanosis of the conjunctiva</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1985-02</date><risdate>1985</risdate><volume>16</volume><issue>2</issue><spage>129</spage><epage>135</epage><pages>129-135</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Forty-one cases of conjunctival primary acquired melanosis (PAM) were studied to determine the frequency of progression to malignant melanoma and to establish prognostic parameters for progression to melanoma. Two subdivisions were identified: lesions with cytologically atypical melanocytes (PAM with atypia, 28 lesions, 68.3 per cent) and those lacking cytologically atypical melanocytes (PAM without atypia, 13 lesions, 31.7 per cent). None of the lesions of PAM without atypia progressed to melanoma. Thirteen of the 28 lesions of PAM with atypia (46.4 per cent) progressed to melanoma. Progression to melanoma was more frequent in the lesions of PAM with atypia if basilar hyperplasia was not the dominant histologic pattern (90 per cent progression,
P=0.02) or if any epithelioid cells were present (75 per cent progression,
P=0.02). It was not possible to determine which lesions were atypical on the basis of clinical appearance. Lesions at risk for the development of melanoma should be totally extirpated.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3972395</pmid><doi>10.1016/S0046-8177(85)80061-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Human pathology, 1985-02, Vol.16 (2), p.129-135 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Biopsy Conjunctival Diseases - pathology Conjunctival Diseases - surgery Conjunctival Neoplasms - etiology Epithelium - pathology Follow-Up Studies Humans Hyperplasia Medical sciences Melanocytes Melanoma - etiology Melanosis - pathology Melanosis - surgery Ophthalmology Prognosis Recurrence Risk Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus |
| title | Primary acquired melanosis of the conjunctiva |
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