Direct and indirect immunofluorescent findings in dermatomyositis
Three skin biopsies (proximal nailfold, extensor forearm and buttock) and serum samples were studied by direct and indirect immunofluorescence, immunodiffusion and radioimmunoassay techniques in 6 patients with dermatomyositis. A variety of seroligic and immunopathologic abnormalities was observed i...
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| Veröffentlicht in: | Journal of cutaneous pathology 1985-02, Vol.12 (1), p.18-27 |
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| container_title | Journal of cutaneous pathology |
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| creator | Chen, Z. Maize, J. C. Silver, R. M. Dobson, R.L. Maricq, H. R. Ainsworth, S. K. |
| description | Three skin biopsies (proximal nailfold, extensor forearm and buttock) and serum samples were studied by direct and indirect immunofluorescence, immunodiffusion and radioimmunoassay techniques in 6 patients with dermatomyositis. A variety of seroligic and immunopathologic abnormalities was observed in the patients. Three of ft patients had antinuclear antibodies (ANA) of a speckled pattern mixed with a peculiar dot pattern. Epidermal intercellular deposits of immunoglobulins were seen in the nailfold biopsies of 2 patients; one of them also had IgG deposits in the cytoplasm of epidermal cells. Forearm and buttock biopsies were negative. |
| doi_str_mv | 10.1111/j.1600-0560.1985.tb00425.x |
| format | Article |
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Forearm and buttock biopsies were negative.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/j.1600-0560.1985.tb00425.x</identifier><identifier>PMID: 3919071</identifier><identifier>CODEN: JCUPBN</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Animals ; Antibodies, Antinuclear - analysis ; Autoantibodies - analysis ; Biological and medical sciences ; Biopsy ; Dermatomyositis - immunology ; Dermatomyositis - pathology ; Female ; Fluorescent Antibody Technique ; Haplorhini ; Humans ; Immunodiffusion ; Immunoglobulins - analysis ; Male ; Medical sciences ; Radioimmunoassay ; Rats ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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C.</creatorcontrib><creatorcontrib>Silver, R. M.</creatorcontrib><creatorcontrib>Dobson, R.L.</creatorcontrib><creatorcontrib>Maricq, H. R.</creatorcontrib><creatorcontrib>Ainsworth, S. K.</creatorcontrib><title>Direct and indirect immunofluorescent findings in dermatomyositis</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Three skin biopsies (proximal nailfold, extensor forearm and buttock) and serum samples were studied by direct and indirect immunofluorescence, immunodiffusion and radioimmunoassay techniques in 6 patients with dermatomyositis. A variety of seroligic and immunopathologic abnormalities was observed in the patients. Three of ft patients had antinuclear antibodies (ANA) of a speckled pattern mixed with a peculiar dot pattern. Epidermal intercellular deposits of immunoglobulins were seen in the nailfold biopsies of 2 patients; one of them also had IgG deposits in the cytoplasm of epidermal cells. Forearm and buttock biopsies were negative.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Antibodies, Antinuclear - analysis</subject><subject>Autoantibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Dermatomyositis - immunology</subject><subject>Dermatomyositis - pathology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Haplorhini</subject><subject>Humans</subject><subject>Immunodiffusion</subject><subject>Immunoglobulins - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Skin - immunology</subject><subject>Skin - pathology</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtq3DAYRkVpSSbTPkJhCKU7T39J1q3QRZjcE9IsmrQ7obHkoIkvqWSTmbePjM3so42QvvPpchA6xrDEafzYLDEHyIDxtKEkW3ZrgJyw5fYDmu2jj2gGFGjGlRSH6CjGDQDmkrMDdEAVViDwDJ2c-uCKbmEau_CNHRe-rvumLau-DS4WrukW5ZA1TzExC-tCbbq23rXRdz5-Rp9KU0X3ZZrn6OH87M_qMrv9fXG1OrnNCgZYZmsCVOZuzazhJSZGiTy30nErJMicSeoscCmwIq5UpqAUOywSha1wxEhC5-j7eO5LaP_3Lna69ulxVWUa1_ZRC6YUIcAT-HMEi9DGGFypX4KvTdhpDHrwpzd6kKQHSXrwpyd_epvKX6db-nXt7L46CUv5tyk3sTBVGUxT-LjHFBaEpc_M0a8Re_WV273jAXr1cI-Hfjb2fezcdt834VlzQQXTf-8u9OX1P3X9eH-jH-kbWKSbtw</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Chen, Z.</creator><creator>Maize, J. C.</creator><creator>Silver, R. M.</creator><creator>Dobson, R.L.</creator><creator>Maricq, H. R.</creator><creator>Ainsworth, S. K.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Direct and indirect immunofluorescent findings in dermatomyositis</title><author>Chen, Z. ; Maize, J. C. ; Silver, R. M. ; Dobson, R.L. ; Maricq, H. R. ; Ainsworth, S. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5018-b20384eb5da6f12a9744d8e6d78084583ed0687192ef9ac331e17a971d7e2a823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Antibodies, Antinuclear - analysis</topic><topic>Autoantibodies - analysis</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Dermatomyositis - immunology</topic><topic>Dermatomyositis - pathology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Haplorhini</topic><topic>Humans</topic><topic>Immunodiffusion</topic><topic>Immunoglobulins - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Skin - immunology</topic><topic>Skin - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Z.</creatorcontrib><creatorcontrib>Maize, J. C.</creatorcontrib><creatorcontrib>Silver, R. M.</creatorcontrib><creatorcontrib>Dobson, R.L.</creatorcontrib><creatorcontrib>Maricq, H. R.</creatorcontrib><creatorcontrib>Ainsworth, S. K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Z.</au><au>Maize, J. C.</au><au>Silver, R. M.</au><au>Dobson, R.L.</au><au>Maricq, H. R.</au><au>Ainsworth, S. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct and indirect immunofluorescent findings in dermatomyositis</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>1985-02</date><risdate>1985</risdate><volume>12</volume><issue>1</issue><spage>18</spage><epage>27</epage><pages>18-27</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>Three skin biopsies (proximal nailfold, extensor forearm and buttock) and serum samples were studied by direct and indirect immunofluorescence, immunodiffusion and radioimmunoassay techniques in 6 patients with dermatomyositis. A variety of seroligic and immunopathologic abnormalities was observed in the patients. Three of ft patients had antinuclear antibodies (ANA) of a speckled pattern mixed with a peculiar dot pattern. Epidermal intercellular deposits of immunoglobulins were seen in the nailfold biopsies of 2 patients; one of them also had IgG deposits in the cytoplasm of epidermal cells. Forearm and buttock biopsies were negative.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3919071</pmid><doi>10.1111/j.1600-0560.1985.tb00425.x</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0303-6987 |
| ispartof | Journal of cutaneous pathology, 1985-02, Vol.12 (1), p.18-27 |
| issn | 0303-6987 1600-0560 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Animals Antibodies, Antinuclear - analysis Autoantibodies - analysis Biological and medical sciences Biopsy Dermatomyositis - immunology Dermatomyositis - pathology Female Fluorescent Antibody Technique Haplorhini Humans Immunodiffusion Immunoglobulins - analysis Male Medical sciences Radioimmunoassay Rats Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin - immunology Skin - pathology |
| title | Direct and indirect immunofluorescent findings in dermatomyositis |
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