Distinct requirements of positive and negative selection for selecting cell type and CD8 interaction

We investigated the requirements of positive and negative selection in the thymus for CD8 interaction and the selecting cell type. Thymic epithelial cells are known to mediate positive selection, whereas thymocytes fail to do so. The reason for this failure could be either the low amount of MHC clas...

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Veröffentlicht in:	The Journal of immunology (1950) 1993-10, Vol.151 (8), p.4098-4105
Hauptverfasser:	Schonrich, G, Strauss, G, Muller, KP, Dustin, L, Loh, DY, Auphan, N, Schmitt- Verhulst, AM, Arnold, B, Hammerling, GJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, T-Lymphocyte - physiology Biological and medical sciences CD2 Antigens CD8 Antigens - analysis CD8 Antigens - physiology Female Fundamental and applied biological sciences. Psychology Fundamental immunology H-2 Antigens - analysis Histocompatibility Antigens Class I - analysis Immunobiology Lymphoid organs: ontogeny, organization, homing phenomenon Male Mice Mice, Inbred DBA Mice, Transgenic Receptors, Antigen, T-Cell - physiology Receptors, Immunologic - physiology Thymus Gland - cytology Thymus Gland - immunology
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