Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase

Human neutrophils contain a neutral metalloproteinase which degrades denatured collagens and potentiates the action of interstitial collagenase. This gelatinase is rapidly secreted from neutrophils stimulated with phorbol myristate acetate. The secreted enzyme has been purified by a combination of c...

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Veröffentlicht in:	The Journal of biological chemistry 1985-02, Vol.260 (4), p.2493-2500
Hauptverfasser:	Hibbs, M S, Hasty, K A, Seyer, J M, Kang, A H, Mainardi, C L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Cells, Cultured Chromatography Collagen - metabolism Edetic Acid - pharmacology Electrophoresis, Polyacrylamide Gel Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Gelatinases Humans Hydrolases Immunoenzyme Techniques Molecular Weight Neutrophils - enzymology Pepsin A - isolation & purification Pepsin A - metabolism Substrate Specificity
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