Iron-induced accumulation of lipofuscin-like fluorescent pigment in the retinal pigment epithelium

One of the most prominent changes that occurs in the retinal pigment epithelium during senescence is the progressive accumulation of the autofluorescent pigment lipofuscin. Experiments were conducted to evaluate the role of nonenzymatic oxidation of photoreceptor outer segments in retinal pigment ep...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1993-10, Vol.34 (11), p.3161-3171
Hauptverfasser:	Katz, ML, Stientjes, HJ, Gao, CL, Christianson, JS
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromatography, Thin Layer Ferrous Compounds Fluorescence Injections Lipofuscin - metabolism Male Medical sciences Microscopy, Fluorescence Ophthalmology Oxidation-Reduction Photoreceptor Cells - drug effects Photoreceptor Cells - metabolism Photoreceptor Cells - ultrastructure Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - ultrastructure Rats Rats, Inbred F344 Retinal Pigments - metabolism Retinopathies Vitreous Body
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