Human monoclonal antibodies from a patient with primary biliary cirrhosis that recognize two distinct autoepitopes in the E2 component of the pyruvate dehydrogenase complex

Peripheral B lymphocytes from a patient with primary biliary cirrhosis were infected with Epstein‐Barr virus, and Epstein‐Barr virus–transformed B lymphocytes producing large amounts of IgG antibodies to pyruvate dehydrogenase complex were selected, expanded and fused with the human‐mouse heteromyel...

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