Abnormal behavioural changes associated with vasopressin-induced barrel rotations
Arginine-8-vasopressin (AVP) was injected into the cerebral ventricles of rats in order to characterize the dose-response relations of the convulsant actions of AVP and to obtain a detailed description of other acute behavioural effects. The incidence of barrel rotations, a violent and apparently un...
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| Veröffentlicht in: | Brain research 1985-02, Vol.326 (1), p.65-70 |
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| container_title | Brain research |
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| creator | Boakes, R.J. Ednie, J.M. Edwardson, J.A. Keith, A.B. Sahgal, A. Wright, C. |
| description | Arginine-8-vasopressin (AVP) was injected into the cerebral ventricles of rats in order to characterize the dose-response relations of the convulsant actions of AVP and to obtain a detailed description of other acute behavioural effects. The incidence of barrel rotations, a violent and apparently uncontrolled motor activity during which rats rotate about their long axis, was found to be dose dependent, with a threshold of between 1 and 10 ng per rat. Other behavioural effects of AVP including immobility, titubation, ataxia, backward walking, and inhibition of exploratory activities and of grooming were seen at doses as low as 100 pg. These behavioural effects occured within 9 min after injection, and thus have the same time course as barrel rotations.
These acute actions of AVP may be significant in interpreting the effects of AVP on cognitive processes and memory and should also be taken into consideration in the clinical use of AVP as an anti-amnestic. |
| doi_str_mv | 10.1016/0006-8993(85)91384-8 |
| format | Article |
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These acute actions of AVP may be significant in interpreting the effects of AVP on cognitive processes and memory and should also be taken into consideration in the clinical use of AVP as an anti-amnestic.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(85)91384-8</identifier><identifier>PMID: 3971149</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>abnormal behaviour ; Animals ; Arginine Vasopressin - pharmacology ; barrel rotataions ; Behavior, Animal - drug effects ; Exploratory Behavior - drug effects ; Grooming - drug effects ; Injections, Intraventricular ; Locomotion - drug effects ; Male ; Motor Activity - drug effects ; Rats ; Rats, Inbred Strains ; vasopressin</subject><ispartof>Brain research, 1985-02, Vol.326 (1), p.65-70</ispartof><rights>1985 Elsevier Science Publishers B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-fa44de41efc3a16bd4091f8a21904cde5d16a652fcfbbcd5c58eec26766d6ba3</citedby><cites>FETCH-LOGICAL-c388t-fa44de41efc3a16bd4091f8a21904cde5d16a652fcfbbcd5c58eec26766d6ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899385913848$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3971149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boakes, R.J.</creatorcontrib><creatorcontrib>Ednie, J.M.</creatorcontrib><creatorcontrib>Edwardson, J.A.</creatorcontrib><creatorcontrib>Keith, A.B.</creatorcontrib><creatorcontrib>Sahgal, A.</creatorcontrib><creatorcontrib>Wright, C.</creatorcontrib><title>Abnormal behavioural changes associated with vasopressin-induced barrel rotations</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Arginine-8-vasopressin (AVP) was injected into the cerebral ventricles of rats in order to characterize the dose-response relations of the convulsant actions of AVP and to obtain a detailed description of other acute behavioural effects. The incidence of barrel rotations, a violent and apparently uncontrolled motor activity during which rats rotate about their long axis, was found to be dose dependent, with a threshold of between 1 and 10 ng per rat. Other behavioural effects of AVP including immobility, titubation, ataxia, backward walking, and inhibition of exploratory activities and of grooming were seen at doses as low as 100 pg. These behavioural effects occured within 9 min after injection, and thus have the same time course as barrel rotations.
These acute actions of AVP may be significant in interpreting the effects of AVP on cognitive processes and memory and should also be taken into consideration in the clinical use of AVP as an anti-amnestic.</description><subject>abnormal behaviour</subject><subject>Animals</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>barrel rotataions</subject><subject>Behavior, Animal - drug effects</subject><subject>Exploratory Behavior - drug effects</subject><subject>Grooming - drug effects</subject><subject>Injections, Intraventricular</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>vasopressin</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc07_gUKvRC-qSZOmyY0whl8wEGH3IU1OXaRtZtJO_Pe2bnipVznhfc574EHonOAbggm_xRjzVEhJr0R-LQkVLBUHaEpEkaU8Y_gQTX-RY3QS4_vwpVTiCZpQWRDC5BS9zsvWh0bXSQlrvXW-D8Ns1rp9g5joGL1xugObfLpunWx19JsAMbo2da3tzRCUOgSok-A73TnfxlN0VOk6wtn-naHVw_1q8ZQuXx6fF_NlaqgQXVppxiwwApWhmvDSMixJJXRGJGbGQm4J1zzPKlOVpbG5yQWAyXjBueWlpjN0uavdBP_RQ-xU46KButYt-D6qIpdCSCL-BQljNMcFHkC2A03wMQao1Ca4RocvRbAajatRpxp1KpGrH-Nq7L_Y9_dlA_Z3aa94yO92OQwytg6CisZBO6hzAUynrHd_H_gGFemSNQ</recordid><startdate>19850204</startdate><enddate>19850204</enddate><creator>Boakes, R.J.</creator><creator>Ednie, J.M.</creator><creator>Edwardson, J.A.</creator><creator>Keith, A.B.</creator><creator>Sahgal, A.</creator><creator>Wright, C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19850204</creationdate><title>Abnormal behavioural changes associated with vasopressin-induced barrel rotations</title><author>Boakes, R.J. ; Ednie, J.M. ; Edwardson, J.A. ; Keith, A.B. ; Sahgal, A. ; Wright, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-fa44de41efc3a16bd4091f8a21904cde5d16a652fcfbbcd5c58eec26766d6ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>abnormal behaviour</topic><topic>Animals</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>barrel rotataions</topic><topic>Behavior, Animal - drug effects</topic><topic>Exploratory Behavior - drug effects</topic><topic>Grooming - drug effects</topic><topic>Injections, Intraventricular</topic><topic>Locomotion - drug effects</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>vasopressin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boakes, R.J.</creatorcontrib><creatorcontrib>Ednie, J.M.</creatorcontrib><creatorcontrib>Edwardson, J.A.</creatorcontrib><creatorcontrib>Keith, A.B.</creatorcontrib><creatorcontrib>Sahgal, A.</creatorcontrib><creatorcontrib>Wright, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boakes, R.J.</au><au>Ednie, J.M.</au><au>Edwardson, J.A.</au><au>Keith, A.B.</au><au>Sahgal, A.</au><au>Wright, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal behavioural changes associated with vasopressin-induced barrel rotations</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1985-02-04</date><risdate>1985</risdate><volume>326</volume><issue>1</issue><spage>65</spage><epage>70</epage><pages>65-70</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Arginine-8-vasopressin (AVP) was injected into the cerebral ventricles of rats in order to characterize the dose-response relations of the convulsant actions of AVP and to obtain a detailed description of other acute behavioural effects. The incidence of barrel rotations, a violent and apparently uncontrolled motor activity during which rats rotate about their long axis, was found to be dose dependent, with a threshold of between 1 and 10 ng per rat. Other behavioural effects of AVP including immobility, titubation, ataxia, backward walking, and inhibition of exploratory activities and of grooming were seen at doses as low as 100 pg. These behavioural effects occured within 9 min after injection, and thus have the same time course as barrel rotations.
These acute actions of AVP may be significant in interpreting the effects of AVP on cognitive processes and memory and should also be taken into consideration in the clinical use of AVP as an anti-amnestic.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>3971149</pmid><doi>10.1016/0006-8993(85)91384-8</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | abnormal behaviour Animals Arginine Vasopressin - pharmacology barrel rotataions Behavior, Animal - drug effects Exploratory Behavior - drug effects Grooming - drug effects Injections, Intraventricular Locomotion - drug effects Male Motor Activity - drug effects Rats Rats, Inbred Strains vasopressin |
| title | Abnormal behavioural changes associated with vasopressin-induced barrel rotations |
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