Bcl-2 functions in an antioxidant pathway to prevent apoptosis

Bcl-2 inhibits most types of apoptotic cell death, implying a common mechanism of lethality. Bcl-2 is localized to intracellular sites of oxygen free radical generation including mitochondria, endoplasmic reticula, and nuclear membranes. Antioxidants that scavenge peroxides, N-acetylcysteine and glu...

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Veröffentlicht in:	Cell 1993-10, Vol.75 (2), p.241-251
Hauptverfasser:	Hockenbery, David M., Oltvai, Zoltan N., Yin, Xiao-Ming, Milliman, Curt L., Korsmeyer, Stanley J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Ageing, cell death Animals Antioxidants Apoptosis - physiology Base Sequence Biological and medical sciences Cell Compartmentation Cell Line Cell physiology Cell Survival Cyanides - pharmacology Free Radicals Fundamental and applied biological sciences. Psychology Glucocorticoids - deficiency Glutathione Peroxidase - metabolism Humans Interleukin-3 - deficiency Lipid Peroxidation - physiology Mice Molecular and cellular biology Molecular Sequence Data Oxygen - metabolism Oxygen Consumption Proto-Oncogene Proteins - isolation & purification Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcl-2 Recombinant Proteins - biosynthesis Respiratory Burst - drug effects Superoxide Dismutase - metabolism Superoxides - metabolism Vitamin K - pharmacology
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