WTX mutations can occur both early and late in the pathogenesis of Wilms tumour

BackgroundSomatic mutations in the X-linked tumour suppressor gene WTX have been observed in 6– 30% of sporadic cases of Wilms tumour. Germline mutations in the same gene cause the sclerosing skeletal dysplasia, osteopathia striata congenita with cranial sclerosis (OSCS). No evidence points towards...

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