Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis

BackgroundPatients with cystic fibrosis (CF) with Pseudomonas aeruginosa lung infections produce endobronchial mucus plugs allowing growth of obligate anaerobes including Prevotella spp. Whether obligate anaerobes contribute to the pathophysiology of CF lung disease is unknown.MethodsThe virulence o...

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Veröffentlicht in:	Thorax 2010-11, Vol.65 (11), p.978-984
Hauptverfasser:	Ulrich, Martina, Beer, Isabelle, Braitmaier, Peter, Dierkes, Michaela, Kummer, Florian, Krismer, Bernhard, Schumacher, Ulrike, Gräpler-Mainka, Ute, Riethmüller, Joachim, Jensen, Peter Ø, Bjarnsholt, Thomas, Høiby, Niels, Bellon, Gabriel, Döring, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Animals Antibiotics Antibodies, Bacterial - blood Bacteroidaceae Infections - complications Biological and medical sciences Bronchoalveolar Lavage Fluid - microbiology Cardiology. Vascular system Cell death Cells, Cultured Colony Count, Microbial Cystic fibrosis Cystic Fibrosis - complications Cytotoxicity Errors of metabolism Humans Hypoxia Infections Investigations Lung - microbiology Lung diseases Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Microorganisms Miscellaneous hereditary metabolic disorders Neutrophils Opportunistic Infections - complications Pathogens Pneumology Prevotella intermedia - growth & development Prevotella intermedia - immunology Prevotella intermedia - isolation & purification Prevotella intermedia - pathogenicity Pseudomonas aeruginosa - growth & development Pseudomonas aeruginosa - isolation & purification Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - complications respiratory infection Respiratory Tract Infections - complications Sputum - microbiology Virulence
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