Does tidal exhaled nitric oxide reflect mucosal airway inflammation in infants?
Using transmission electron microscopy, the numbers of subepithelial eosinophils, neutrophils, mast cells, plasma cells, and lymphomononuclear cells, identified by their ultrastructure, were determined in ultrathin sections obtained from the endobronchial biopsies. 3 As there are no reference data i...
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| Veröffentlicht in: | Thorax 2010-11, Vol.65 (11), p.1027-1027 |
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| creator | Malmberg, L Pekka Malmström, Kristiina Kotaniemi-Syrjänen, Anne Lindahl, Harry Kajosaari, Merja Turpeinen, Markku Haahtela, Tari Saglani, Sejal Bush, Andrew Jeffery, Peter K Pelkonen, Anna S Mäkelä, Mika J |
| description | Using transmission electron microscopy, the numbers of subepithelial eosinophils, neutrophils, mast cells, plasma cells, and lymphomononuclear cells, identified by their ultrastructure, were determined in ultrathin sections obtained from the endobronchial biopsies. 3 As there are no reference data in normal healthy infants, we used an arbitrary classification based on the median count of each cell line ( =50th percentile=high). Only the results in atopic infants favoured an association between FENO and eosinophils. [...]although it seems unlikely that FENO,TB would be a useful predictor of corticosteroid responsiveness in unselected infants with severe recurrent respiratory symptoms, its usefulness in selected infants with recurrent wheeze remains to be studied further. |
| doi_str_mv | 10.1136/thx.2009.128587 |
| format | Article |
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Only the results in atopic infants favoured an association between FENO and eosinophils. [...]although it seems unlikely that FENO,TB would be a useful predictor of corticosteroid responsiveness in unselected infants with severe recurrent respiratory symptoms, its usefulness in selected infants with recurrent wheeze remains to be studied further.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.2009.128587</identifier><identifier>PMID: 20880878</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Asthma ; Biopsy ; Breath Tests - methods ; Child, Preschool ; Eosinophilia - diagnosis ; Exhaled airway markers ; Exhaled nitric oxide ; histology/cytology ; Humans ; Infant ; Inflammation ; Neutrophils ; Nitric Oxide - metabolism ; paediatric asthma ; Respiration Disorders - diagnosis ; Studies ; wheeze</subject><ispartof>Thorax, 2010-11, Vol.65 (11), p.1027-1027</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b438t-1032c624251db144787bba480e8d82a49609a9b98df25d8d0a329198e5d1f0283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://thorax.bmj.com/content/65/11/1027.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://thorax.bmj.com/content/65/11/1027.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20880878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malmberg, L Pekka</creatorcontrib><creatorcontrib>Malmström, Kristiina</creatorcontrib><creatorcontrib>Kotaniemi-Syrjänen, Anne</creatorcontrib><creatorcontrib>Lindahl, Harry</creatorcontrib><creatorcontrib>Kajosaari, Merja</creatorcontrib><creatorcontrib>Turpeinen, Markku</creatorcontrib><creatorcontrib>Haahtela, Tari</creatorcontrib><creatorcontrib>Saglani, Sejal</creatorcontrib><creatorcontrib>Bush, Andrew</creatorcontrib><creatorcontrib>Jeffery, Peter K</creatorcontrib><creatorcontrib>Pelkonen, Anna S</creatorcontrib><creatorcontrib>Mäkelä, Mika J</creatorcontrib><title>Does tidal exhaled nitric oxide reflect mucosal airway inflammation in infants?</title><title>Thorax</title><addtitle>Thorax</addtitle><description>Using transmission electron microscopy, the numbers of subepithelial eosinophils, neutrophils, mast cells, plasma cells, and lymphomononuclear cells, identified by their ultrastructure, were determined in ultrathin sections obtained from the endobronchial biopsies. 3 As there are no reference data in normal healthy infants, we used an arbitrary classification based on the median count of each cell line ( =50th percentile=high). Only the results in atopic infants favoured an association between FENO and eosinophils. [...]although it seems unlikely that FENO,TB would be a useful predictor of corticosteroid responsiveness in unselected infants with severe recurrent respiratory symptoms, its usefulness in selected infants with recurrent wheeze remains to be studied further.</description><subject>Asthma</subject><subject>Biopsy</subject><subject>Breath Tests - methods</subject><subject>Child, Preschool</subject><subject>Eosinophilia - diagnosis</subject><subject>Exhaled airway markers</subject><subject>Exhaled nitric oxide</subject><subject>histology/cytology</subject><subject>Humans</subject><subject>Infant</subject><subject>Inflammation</subject><subject>Neutrophils</subject><subject>Nitric Oxide - metabolism</subject><subject>paediatric asthma</subject><subject>Respiration Disorders - diagnosis</subject><subject>Studies</subject><subject>wheeze</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkE1P3DAQhi1UBFvKmRuK1ANSpSxjJ7HHpwot_aCipQfK1XJiR3jJB9iOuvz7Ogrl0EtP1sjPvDPzEHJCYU1pwc_j_W7NAOSaMqxQ7JEVLTnmBZP8DVkBlJDzQvBD8jaELQAgpeKAHDJABBS4IjeXow1ZdEZ3md3d686abHDRuyYbd87YzNu2s03M-qkZQ4K087_1c-aGttN9r6Mbh1TMtR5i-PiO7Le6C_b45T0ivz5_ut18za9vvlxtLq7zuiww5hQK1nBWsoqampalQFHXukSwaJDpUnKQWtYSTcsqgwZ0OolKtJWhLTAsjsjZkvvox6fJhqh6FxrbdXqw4xSUqCQKgRVN5Pt_yO04-SEtp6hAigC0mPPOF6rxYwjpaPXoXa_9s6KgZtUqqVazarWoTh2nL7lT3Vvzyv91m4B8AVyIdvf6r_2D4qIQlfpxt1G8kt--_7y7VTP_YeHrfvvf6X8AnrqUyg</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Malmberg, L Pekka</creator><creator>Malmström, Kristiina</creator><creator>Kotaniemi-Syrjänen, Anne</creator><creator>Lindahl, Harry</creator><creator>Kajosaari, Merja</creator><creator>Turpeinen, Markku</creator><creator>Haahtela, Tari</creator><creator>Saglani, Sejal</creator><creator>Bush, Andrew</creator><creator>Jeffery, Peter K</creator><creator>Pelkonen, Anna S</creator><creator>Mäkelä, Mika J</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Does tidal exhaled nitric oxide reflect mucosal airway inflammation in infants?</title><author>Malmberg, L Pekka ; 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Only the results in atopic infants favoured an association between FENO and eosinophils. [...]although it seems unlikely that FENO,TB would be a useful predictor of corticosteroid responsiveness in unselected infants with severe recurrent respiratory symptoms, its usefulness in selected infants with recurrent wheeze remains to be studied further.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>20880878</pmid><doi>10.1136/thx.2009.128587</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Thorax, 2010-11, Vol.65 (11), p.1027-1027 |
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| source | MEDLINE; BMJ Journals - NESLi2; Alma/SFX Local Collection |
| subjects | Asthma Biopsy Breath Tests - methods Child, Preschool Eosinophilia - diagnosis Exhaled airway markers Exhaled nitric oxide histology/cytology Humans Infant Inflammation Neutrophils Nitric Oxide - metabolism paediatric asthma Respiration Disorders - diagnosis Studies wheeze |
| title | Does tidal exhaled nitric oxide reflect mucosal airway inflammation in infants? |
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