Rearrangement of Immunoglobulin Heavy Chain Genes in T Cell Acute Lymphoblastic Leukemia

We studied the arrangement of the immunoglobulin heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the Cμ and JH gene segments: At least one of the Cμ-gene alleles was rearranged...

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